PMID- 35615525 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 2050-3121 (Print) IS - 2050-3121 (Electronic) IS - 2050-3121 (Linking) VI - 10 DP - 2022 TI - A Narrative Review of Current Concerns and Future Perspectives of the Carbohydrate Mouth Rinse Effects on Exercise Performance. PG - 20503121221098120 LID - 10.1177/20503121221098120 [doi] LID - 20503121221098120 AB - Previous systematic reviews have confirmed that carbohydrate (CHO) mouth rinse may boost physical exercise performance, despite some methodological aspects likely affecting its ergogenic effect. In this review, we discussed if the exercise mode, pre-exercise fasting status, CHO solutions concentration, CHO solutions temperature, mouth rinse duration, and CHO placebo effects may potentially reduce the CHO mouth rinse ergogenic effect, suggesting possible solutions to manage these potential confounders. The effectiveness of CHO mouth rinse as a performance booster is apparently related to the origin of the exercise-induced neuromuscular fatigue, as CHO mouth rinse unequivocally potentiates endurance rather than sprint and strength exercises performance. Furthermore, ergogenic effects have been greater in fasting than fed state, somehow explaining the varied magnitude of the CHO mouth rinse effects in exercise performance. In this regard, the CHO solution concentration and temperature, as well as the mouth rinse duration, may have increased the variability observed in CHO mouth rinse effects in fasting and fed state. Finally, placebo effects have challenged the potential of the CHO mouth rinse as an ergogenic aid. Therefore, we suggest that future studies should consider methodological controls such as sample size and sample homogeneity, proper familiarization with experimental procedures, and the use of alternative placebo designs to provide unbiased evidence regarding the potential of the CHO mouth rinse as an ergogenic aid. CI - (c) The Author(s) 2022. FAU - Painelli, Vitor de Salles AU - Painelli VS AD - Exercise Psychophysiology Research Group, School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, Brazil. AD - Strength Training Study and Research Group, Institute of Health Sciences, Paulista University, Sao Paulo, Brazil. FAU - Brietzke, Cayque AU - Brietzke C AUID- ORCID: 0000-0002-7557-3140 AD - Exercise Psychophysiology Research Group, School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, Brazil. AD - Human Movement Science and Rehabilitation Program, Federal University of Sao Paulo, Santos, Brazil. FAU - Franco-Alvarenga, Paulo Estevao AU - Franco-Alvarenga PE AD - Exercise Psychophysiology Research Group, School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, Brazil. AD - Human Movement Science and Rehabilitation Program, Federal University of Sao Paulo, Santos, Brazil. FAU - Canestri, Raul AU - Canestri R AD - Exercise Psychophysiology Research Group, School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, Brazil. FAU - Vinicius, Italo AU - Vinicius I AD - Exercise Psychophysiology Research Group, School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, Brazil. FAU - Pires, Flavio Oliveira AU - Pires FO AUID- ORCID: 0000-0003-4538-1751 AD - Exercise Psychophysiology Research Group, School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, Brazil. AD - Human Movement Science and Rehabilitation Program, Federal University of Sao Paulo, Santos, Brazil. LA - eng PT - Journal Article PT - Review DEP - 20220513 PL - England TA - SAGE Open Med JT - SAGE open medicine JID - 101624744 PMC - PMC9125602 OTO - NOTNLM OT - Central fatigue OT - Nutritional supplementation OT - Peripheral fatigue OT - Physical tests OT - Placebo COIS- Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2022/05/27 06:00 MHDA- 2022/05/27 06:01 PMCR- 2022/05/13 CRDT- 2022/05/26 02:26 PHST- 2021/12/24 00:00 [received] PHST- 2022/04/13 00:00 [accepted] PHST- 2022/05/26 02:26 [entrez] PHST- 2022/05/27 06:00 [pubmed] PHST- 2022/05/27 06:01 [medline] PHST- 2022/05/13 00:00 [pmc-release] AID - 10.1177_20503121221098120 [pii] AID - 10.1177/20503121221098120 [doi] PST - epublish SO - SAGE Open Med. 2022 May 13;10:20503121221098120. doi: 10.1177/20503121221098120. eCollection 2022.