PMID- 35615874
OWN - NLM
STAT- MEDLINE
DCOM- 20220713
LR  - 20220803
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 100
IP  - 1
DP  - 2022 Jul
TI  - Safety and efficacy of transcatheter mitral valve repair in patients with COPD; 
      results from real-world cohort.
PG  - 145-153
LID - 10.1002/ccd.30238 [doi]
AB  - OBJECTIVE: To evaluate the safety and efficacy of transcatheter mitral valve 
      repair (TMVR) in patients with chronic obstructive pulmonary disease (COPD). 
      BACKGROUND: Heart failure and COPD share many clinical features and commonly 
      coexist. Data about the safety and efficacy of TMVR in patients with COPD is not 
      conclusive. METHODS: Three hundred and forty consecutive patients undergoing TMVR 
      were retrospectively included. COPD diagnosis was based on pulmonary function 
      tests (PFTs). Intra-hospital, 30-day- and 1-year outcomes were compared between 
      both groups. RESULTS: Eighty-two patients had COPD (24%). There was no difference 
      in intra-hospital mortality between patients with and without COPD (both 5%, 
      p = 0.95). Among patients who had a successful procedure and survived to 
      discharge there was a trend toward more rehospitalization due to decompensated 
      heart failure at 30-day follow-up in patients with COPD (12.9% vs. 6.8%, 
      p = 0.08) with no difference in mortality. At median follow-up of 1 year, New 
      York heart association (NYHA) category was comparable among both groups and there 
      was no significant difference in rehospitalization (COPD: 29.9% vs. non-COPD: 
      34%, p = 0.5). There was a trend toward increased 1-year mortality in COPD 
      patients (31.2% vs. 20.6%, p = 0.06). However, a composite endpoint of 
      rehospitalization or death at 1 year did not differ between both groups (48% vs. 
      42.5%, p = 0.4). Regression analysis showed no correlation between COPD severity 
      and worse TMVR outcomes. CONCLUSIONS: COPD is highly prevalent among patients 
      undergoing TMVR. However, TMVR seems to be safe and effective in COPD patients. 
      COPD severity and PFT impairment alone should not be considered as a 
      contraindication for TMVR.
CI  - (c) 2022 The Authors. Catheterization and Cardiovascular Interventions published by 
      Wiley Periodicals LLC.
FAU - Alachkar, Mhd Nawar
AU  - Alachkar MN
AUID- ORCID: 0000-0001-5883-2561
AD  - Department of Cardiology, Angiology and Intensive Care Medicine, University 
      Hospital RWTH, Aachen, Germany.
FAU - Muller, Tobias
AU  - Muller T
AD  - Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, 
      Aachen, Germany.
FAU - Alnaimi, Anas
AU  - Alnaimi A
AD  - Department of Cardiology, Angiology and Intensive Care Medicine, University 
      Hospital RWTH, Aachen, Germany.
FAU - Milzi, Andrea
AU  - Milzi A
AD  - Department of Cardiology, Angiology and Intensive Care Medicine, University 
      Hospital RWTH, Aachen, Germany.
FAU - Kneizeh, Kinan
AU  - Kneizeh K
AD  - Department of Cardiology, Angiology and Intensive Care Medicine, University 
      Hospital RWTH, Aachen, Germany.
FAU - Altiok, Ertunc
AU  - Altiok E
AD  - Department of Cardiology, Angiology and Intensive Care Medicine, University 
      Hospital RWTH, Aachen, Germany.
FAU - Schroder, Jorg
AU  - Schroder J
AD  - Department of Cardiology, Angiology and Intensive Care Medicine, University 
      Hospital RWTH, Aachen, Germany.
FAU - Reith, Sebastian
AU  - Reith S
AD  - Department of Cardiology, Angiology and Intensive Care Medicine, University 
      Hospital RWTH, Aachen, Germany.
AD  - Clinic for Cardiology and Angiology, St. Franziskus-Hospital, Munster, Germany.
FAU - Marx, Nikolaus
AU  - Marx N
AD  - Department of Cardiology, Angiology and Intensive Care Medicine, University 
      Hospital RWTH, Aachen, Germany.
FAU - Dreher, Michael
AU  - Dreher M
AD  - Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, 
      Aachen, Germany.
FAU - Almalla, Mohammad
AU  - Almalla M
AUID- ORCID: 0000-0003-4765-109X
AD  - Department of Cardiology, Angiology and Intensive Care Medicine, University 
      Hospital RWTH, Aachen, Germany.
FAU - Daher, Ayham
AU  - Daher A
AD  - Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, 
      Aachen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20220526
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
SB  - IM
MH  - Cardiac Catheterization/methods
MH  - *Heart Failure
MH  - *Heart Valve Prosthesis Implantation/methods
MH  - Humans
MH  - Mitral Valve/diagnostic imaging/surgery
MH  - *Mitral Valve Insufficiency/diagnostic imaging/surgery
MH  - *Pulmonary Disease, Chronic Obstructive/complications/diagnosis
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - COPD
OT  - mitral regurgitation
OT  - mortality
OT  - outcome
OT  - pulmonary function test
OT  - transcatheter mitral valve repair
EDAT- 2022/05/27 06:00
MHDA- 2022/07/14 06:00
CRDT- 2022/05/26 03:32
PHST- 2022/01/11 00:00 [received]
PHST- 2022/05/09 00:00 [accepted]
PHST- 2022/05/27 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/05/26 03:32 [entrez]
AID - 10.1002/ccd.30238 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2022 Jul;100(1):145-153. doi: 10.1002/ccd.30238. Epub 
      2022 May 26.