PMID- 35616241
OWN - NLM
STAT- MEDLINE
DCOM- 20220726
LR  - 20220727
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 36
IP  - 4
DP  - 2022 Jul
TI  - Serial evaluation of thoracic radiographs and acute phase proteins in dogs with 
      pneumonia.
PG  - 1430-1443
LID - 10.1111/jvim.16448 [doi]
AB  - BACKGROUND: Acute phase proteins (APP) may guide treatment of pneumonia in dogs 
      but correlations with radiographic abnormalities are poorly characterized. 
      OBJECTIVES: Develop a thoracic radiographic severity scoring system (TRSS), 
      assess correlation of radiographic changes with APP concentrations, and compare 
      time to APP and radiograph normalization with duration of antimicrobials 
      treatment. ANIMALS: Sixteen client-owned dogs, 12 with aspiration pneumonia, and 
      4 with community-acquired pneumonia. METHODS: Concentrations of C-reactive 
      protein (CRP), serum amyloid A (SAA), and haptoglobin were measured on days 1, 3, 
      7, 14, 28, and 60 and orthogonal 2-view thoracic radiographs were obtained on 
      days 1, 7, 14, 28, and 60. Treatment was clinician-guided and blinded to APP 
      concentrations. Radiographic severity scores were assigned by blinded, randomized 
      retrospective review by 2 board-certified radiologists with arbitration by a 
      third radiologist. RESULTS: Median (interquartile range [IQR]) time to 
      normalization of CRP (7 days [7-14]) and SAA concentrations (7 days [7-14]) were 
      shorter than antimicrobial treatment duration (17.5 days [14.5-33.5]; P = .001 
      and .002, respectively) and TRSS normalization (14 days [8.8-52], P = .02 and 
      .02, respectively). The CRP and SAA concentrations were positively correlated 
      with TRSS (CRP r(s) , 0.643; SAA r(s) , 0.634; both P < .0001). Both CRP and SAA 
      identified normal thoracic radiographs area under the curve (AUC) 0.873 and 
      0.817, respectively, both P < .0001. Interobserver agreement for TRSS assignment 
      was moderate (kappa, .499; P < .0001). CONCLUSION AND CLINICAL IMPORTANCE: 
      Concentrations of CRP and SAA normalized before radiographic resolution and 
      before clinicians discontinued antimicrobial treatment. The CRP and SAA 
      concentrations may guide duration of antimicrobial treatment for dogs with 
      pneumonia.
CI  - (c) 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley 
      Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
FAU - Menard, Julie
AU  - Menard J
AUID- ORCID: 0000-0002-2700-2466
AD  - Department of Veterinary Clinical and Diagnostic Science, Faculty of Veterinary 
      Medicine, University of Calgary, Calgary, Alberta, Canada.
FAU - Porter, Ian
AU  - Porter I
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Cornell 
      University, Ithaca, New York, USA.
FAU - Lerer, Assaf
AU  - Lerer A
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Cornell 
      University, Ithaca, New York, USA.
FAU - Robbins, Sarah
AU  - Robbins S
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Cornell 
      University, Ithaca, New York, USA.
FAU - Johnson, Philippa J
AU  - Johnson PJ
AUID- ORCID: 0000-0002-4558-0745
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Cornell 
      University, Ithaca, New York, USA.
FAU - Goggs, Robert
AU  - Goggs R
AUID- ORCID: 0000-0001-7446-6987
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Cornell 
      University, Ithaca, New York, USA.
LA  - eng
GR  - Cornell University/
PT  - Journal Article
DEP - 20220526
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Haptoglobins)
RN  - 0 (Serum Amyloid A Protein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute-Phase Proteins/metabolism
MH  - Animals
MH  - Biomarkers
MH  - C-Reactive Protein/metabolism
MH  - *Dog Diseases/diagnostic imaging/drug therapy
MH  - Dogs
MH  - Haptoglobins
MH  - *Pneumonia/veterinary
MH  - Serum Amyloid A Protein/metabolism
PMC - PMC9308444
OTO - NOTNLM
OT  - CRP
OT  - SAA
OT  - antimicrobial treatment
OT  - haptoglobin
OT  - respiratory disease
OT  - scoring system
COIS- Julie Menard serves as a consultant for the pharmaceutical company Vetoquinol for 
      the launch of 1 of their products. Dr. Menard has also spoken about antimicrobial 
      stewardship and resistance at international conference for which she received 
      payments (European Veterinary Emergency and Critical Care Congres 2020). Dr. 
      Menard is an editor for Frontiers of Veterinary Sciences (Emergency and Critical 
      Care section). No other authors have a conflict of interest.
EDAT- 2022/05/27 06:00
MHDA- 2022/07/27 06:00
PMCR- 2022/07/01
CRDT- 2022/05/26 07:13
PHST- 2021/10/07 00:00 [received]
PHST- 2022/05/04 00:00 [accepted]
PHST- 2022/05/27 06:00 [pubmed]
PHST- 2022/07/27 06:00 [medline]
PHST- 2022/05/26 07:13 [entrez]
PHST- 2022/07/01 00:00 [pmc-release]
AID - JVIM16448 [pii]
AID - 10.1111/jvim.16448 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2022 Jul;36(4):1430-1443. doi: 10.1111/jvim.16448. Epub 2022 
      May 26.