PMID- 35616893
OWN - NLM
STAT- MEDLINE
DCOM- 20220530
LR  - 20220601
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 33
IP  - 5
DP  - 2022 May
TI  - Metabolomics analysis reveals molecular linkages for the impact of vitamin D on 
      childhood allergic airway diseases.
PG  - e13785
LID - 10.1111/pai.13785 [doi]
AB  - BACKGROUND: Several studies have reported the relevance between serum vitamin D 
      and allergic immunoglobulin E (IgE) responses and atopic diseases. However, a 
      metabolomics-based approach to the impacts of vitamin D on allergic reactions 
      remains unclear. METHODS: A total of 111 children completed a 3-year follow-up 
      were enrolled and classified based on longitudinal vitamin D status (>/= 30 ng/ml, 
      n = 54; 20-29.9 ng/ml, n = 41; <20 ng/ml, n = 16). Urinary metabolomic profiling 
      was performed using (1) H-Nuclear magnetic resonance (NMR) spectroscopy at age 3. 
      Integrative analyses of their associations related to vitamin D levels, atopic 
      indices, and allergies were performed, and their roles in functional metabolic 
      pathways were also assessed. RESULTS: Six and five metabolites were identified to 
      be significantly associated with vitamin D status and atopic diseases, 
      respectively (FDR-adjusted p-value <.05). A further correlation analysis revealed 
      that vitamin D-associated 3-hydroxyisobutyric acid and glutamine were positively 
      correlated with atopic disease-associated succinic acid and alanine, 
      respectively. Furthermore, hippuric acid was negatively correlated with atopic 
      disease-associated formic acid, which was positively correlated with vitamin D 
      level (p < .01). Absolute eosinophil count (AEC) was positively correlated with 
      serum D. pteronyssinus- and D. farinae-specific IgE level (p < .01) but 
      negatively correlated with vitamin D level (p < .05). Amino acid metabolisms were 
      significantly associated with vitamin D related to childhood allergies. 
      CONCLUSION: Integrative metabolomic analysis provides the link of vitamin 
      D-associated metabolites with the gut microbiome and immunoallergic reactions 
      related to childhood allergies.
CI  - (c) 2022 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
FAU - Chang, Yu-Ho
AU  - Chang YH
AD  - School of Traditional Chinese Medicine, Chang Gung University College of 
      Medicine, Taoyuan, Taiwan.
FAU - Yeh, Kuo-Wei
AU  - Yeh KW
AUID- ORCID: 0000-0002-2499-8050
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, 
      Taiwan.
FAU - Huang, Jing-Long
AU  - Huang JL
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, 
      Taiwan.
AD  - Department of Pediatrics, New Taipei Municipal TuCheng Hospital, Chang Gung 
      Memorial Hospital and Chang Gung University, Keelung, Taiwan.
FAU - Su, Kuan-Wen
AU  - Su KW
AD  - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, and Chang Gung 
      University College of Medicine, Taoyuan, Taiwan.
FAU - Tsai, Ming-Han
AU  - Tsai MH
AD  - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, and Chang Gung 
      University College of Medicine, Taoyuan, Taiwan.
FAU - Hua, Man-Chin
AU  - Hua MC
AD  - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, and Chang Gung 
      University College of Medicine, Taoyuan, Taiwan.
FAU - Liao, Sui-Ling
AU  - Liao SL
AD  - Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, and Chang Gung 
      University College of Medicine, Taoyuan, Taiwan.
FAU - Lai, Shen-Hao
AU  - Lai SH
AD  - Division of Pediatric Pulmonology, Chang Gung Memorial Hospital at Linkou, 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Chen, Li-Chen
AU  - Chen LC
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, 
      Taiwan.
AD  - Department of Pediatrics, New Taipei Municipal TuCheng Hospital, Chang Gung 
      Memorial Hospital and Chang Gung University, Keelung, Taiwan.
FAU - Chiu, Chih-Yung
AU  - Chiu CY
AUID- ORCID: 0000-0002-6454-968X
AD  - Division of Pediatric Pulmonology, Chang Gung Memorial Hospital at Linkou, 
      College of Medicine, Chang Gung University, Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 1406-16-2 (Vitamin D)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - *Asthma
MH  - Child
MH  - Child, Preschool
MH  - Dermatophagoides farinae
MH  - Humans
MH  - *Hypersensitivity/epidemiology
MH  - Immunoglobulin E
MH  - Metabolomics/methods
MH  - Vitamin D
OTO - NOTNLM
OT  - childhood allergies
OT  - formic acid
OT  - gut microbiome
OT  - hippuric acid
OT  - metabolomics
OT  - vitamin D
EDAT- 2022/05/27 06:00
MHDA- 2022/05/31 06:00
CRDT- 2022/05/26 11:30
PHST- 2022/04/21 00:00 [revised]
PHST- 2021/10/06 00:00 [received]
PHST- 2022/04/25 00:00 [accepted]
PHST- 2022/05/26 11:30 [entrez]
PHST- 2022/05/27 06:00 [pubmed]
PHST- 2022/05/31 06:00 [medline]
AID - 10.1111/pai.13785 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2022 May;33(5):e13785. doi: 10.1111/pai.13785.