PMID- 35616928
OWN - NLM
STAT- MEDLINE
DCOM- 20220530
LR  - 20220716
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 63
IP  - 5
DP  - 2022 May 2
TI  - Choroidal Thickening During Young Adulthood and Baseline Choroidal Thickness 
      Predicts Refractive Error Change.
PG  - 34
LID - 10.1167/iovs.63.5.34 [doi]
LID - 34
AB  - PURPOSE: The purpose of this study was to explore the age-related change in 
      choroidal thickness (ChT) and test the hypothesis that baseline ChT is predictive 
      of refractive error change in healthy young adults. METHODS: Participants 
      underwent spectral-domain optical coherence tomography (SD-OCT) imaging and 
      autorefraction at 20 (baseline) and 28 years old. The enhanced depth imaging mode 
      on the SD-OCT was used to obtain images of the choroid. Scans were exported from 
      the SD-OCT and analyzed with a custom software that automatically measures the 
      central ChT. The longitudinal change in subfoveal ChT and association between 
      baseline subfoveal ChT and 8-year change in refractive error (spherical 
      equivalent) were determined using linear mixed models. RESULTS: In total, 395 
      eyes of 198 participants (44% men; 18-22 years at baseline) were included. Over 8 
      years, mean spherical equivalent decreased by 0.25 diopters (D) and axial length 
      increased by 0.09 mm. Subfoveal choroid thickened by 1.3 microm/year (95% confidence 
      interval [CI] = 0.6-2.0), but this was reduced by 0.9 microm/year (95% CI = 1.6-0.2) 
      for every 1 mm increase in axial length. For every 10 microm increase in baseline 
      ChT, average annual change in spherical equivalent and axial length reduced by 
      0.006 D/year and 0.003 mm/year, respectively. CONCLUSIONS: In a community-based 
      cohort of young adults, the choroid continued to change during early adulthood. 
      Choroidal thickening was less in eyes that were longer at baseline, and the 
      choroid thinned in eyes that showed myopia progression. The association between 
      baseline ChT and longitudinal changes in spherical equivalent and axial length 
      supports the hypothesis that ChT may be predictive of refractive error 
      development and/or myopia progression.
FAU - Lee, Samantha Sze-Yee
AU  - Lee SS
AD  - The University of Western Australia, Centre for Ophthalmology and Visual Science 
      (incorporating the Lions Eye Institute), Perth, Western Australia, Australia.
FAU - Alonso-Caneiro, David
AU  - Alonso-Caneiro D
AD  - Contact Lens and Visual Optic Laboratory, School of Optometry and Vision Science, 
      Queensland University of Technology, Brisbane, Queensland, Australia.
FAU - Lingham, Gareth
AU  - Lingham G
AD  - The University of Western Australia, Centre for Ophthalmology and Visual Science 
      (incorporating the Lions Eye Institute), Perth, Western Australia, Australia.
AD  - Centre for Eye Research Ireland, School of Physics, Clinical and Optometric 
      Sciences, Technological University Dublin, Ireland, Dublin, Ireland.
FAU - Chen, Fred K
AU  - Chen FK
AD  - The University of Western Australia, Centre for Ophthalmology and Visual Science 
      (incorporating the Lions Eye Institute), Perth, Western Australia, Australia.
AD  - Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia, 
      Australia.
FAU - Sanfilippo, Paul G
AU  - Sanfilippo PG
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, East Melbourne, Victoria, Australia.
FAU - Yazar, Seyhan
AU  - Yazar S
AD  - Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical 
      Research, Sydney, New South Wales, Australia.
FAU - Mackey, David A
AU  - Mackey DA
AD  - The University of Western Australia, Centre for Ophthalmology and Visual Science 
      (incorporating the Lions Eye Institute), Perth, Western Australia, Australia.
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, East Melbourne, Victoria, Australia.
AD  - School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, 
      Hobart, Tasmania, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Axial Length, Eye
MH  - Choroid/anatomy & histology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Myopia/diagnosis
MH  - Refraction, Ocular
MH  - *Refractive Errors
MH  - Tomography, Optical Coherence/methods
MH  - Young Adult
PMC - PMC9150825
COIS- Disclosure: S.S.-Y. Lee, None; D. Alonso-Caneiro, None; G. Lingham, None; F.K. 
      Chen, None; P.G. Sanfilippo, None; S. Yazar, None; D.A. Mackey, None
EDAT- 2022/05/27 06:00
MHDA- 2022/05/31 06:00
PMCR- 2022/05/26
CRDT- 2022/05/26 11:34
PHST- 2022/05/26 11:34 [entrez]
PHST- 2022/05/27 06:00 [pubmed]
PHST- 2022/05/31 06:00 [medline]
PHST- 2022/05/26 00:00 [pmc-release]
AID - 2778862 [pii]
AID - IOVS-22-34511 [pii]
AID - 10.1167/iovs.63.5.34 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2022 May 2;63(5):34. doi: 10.1167/iovs.63.5.34.