PMID- 35617800
OWN - NLM
STAT- MEDLINE
DCOM- 20220620
LR  - 20220711
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 615
DP  - 2022 Jul 30
TI  - CaMKII inhibition protects against hyperthyroid arrhythmias and adverse 
      myocardial remodeling.
PG  - 136-142
LID - S0006-291X(22)00617-9 [pii]
LID - 10.1016/j.bbrc.2022.04.082 [doi]
AB  - Hyperthyroidism can potentiate arrhythmias and cardiac hypertrophy, whereas 
      Ca(2+)/calmodulin-dependent kinase II (CaMKII) promotes maladaptive myocardial 
      remodeling. However, it remains unclear whether CaMKII contributes to the 
      progression of hyperthyroid heart disease (HHD). This study demonstrated that 
      CaMKII inhibition can relieve adverse myocardial remodeling and reduce sinus 
      tachycardia, isoproterenol-induced atrial fibrillation, and ventricular 
      arrhythmias in hyperthyroid mice with preserved heart function. Hyperthyroid 
      cardiac hypertrophy was promoted by CaMKII upregulation-induced HDAC4/MEF2a 
      activation. Briefly, CaMKII inhibition benefits HHD management greatly in mice by 
      preventing arrhythmias and maladaptive remodeling.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Nie, Daan
AU  - Nie D
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Xia, Chaorui
AU  - Xia C
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China; Department of 
      Cardiology, Jingzhou First People's Hospital, The First Affiliated Hospital of 
      Yangtze University, Jingzhou, 434000, China.
FAU - Wang, Zhiyu
AU  - Wang Z
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Ding, Peiwu
AU  - Ding P
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Meng, Yidi
AU  - Meng Y
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Liu, Jie
AU  - Liu J
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Li, Ting
AU  - Li T
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Gan, Ting
AU  - Gan T
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Xuan, Baijun
AU  - Xuan B
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Huang, Yun
AU  - Huang Y
AD  - Department of Gerontology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Zhang, Jiaming
AU  - Zhang J
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Su, Guanhua
AU  - Su G
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Li, Jingdong
AU  - Li J
AD  - Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China. Electronic address: 
      jingdong-li@mail.hust.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220420
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
SB  - IM
MH  - Animals
MH  - *Atrial Fibrillation/prevention & control
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2
MH  - Cardiomegaly/prevention & control
MH  - *Hyperthyroidism/complications
MH  - Mice
MH  - Myocardium
MH  - Myocytes, Cardiac
OTO - NOTNLM
OT  - Adverse myocardial remodeling
OT  - CaMKII
OT  - HDAC4
OT  - Hyperthyroid heart disease (HHD)
OT  - MEF2a
OT  - Sinus tachycardia
COIS- Declaration of competing interest The authors have declared that no conflict of 
      interest exists, including Daan Nie, Chaorui Xia, Zhiyu Wang, Peiwu Ding, Yidi 
      Meng, Jie Liu, Ting Li, Ting Gan, Baijun Xuan, Yun Huang, Jiaming Zhang, Guanhua 
      Su and Jingdong Li.
EDAT- 2022/05/27 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/05/26 18:19
PHST- 2022/03/06 00:00 [received]
PHST- 2022/04/08 00:00 [revised]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/05/27 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/05/26 18:19 [entrez]
AID - S0006-291X(22)00617-9 [pii]
AID - 10.1016/j.bbrc.2022.04.082 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2022 Jul 30;615:136-142. doi: 
      10.1016/j.bbrc.2022.04.082. Epub 2022 Apr 20.