PMID- 35618148
OWN - NLM
STAT- MEDLINE
DCOM- 20220615
LR  - 20221221
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 118
DP  - 2022 Aug 30
TI  - The impact of COVID-19 pandemic on individuals at clinical high-risk for 
      psychosis: Evidence from eye-tracking measures.
PG  - 110578
LID - S0278-5846(22)00070-7 [pii]
LID - 10.1016/j.pnpbp.2022.110578 [doi]
AB  - Emerging evidence suggested that people with severe mental disorders were more 
      vulnerable to the negative effects of the COVID-19 pandemic. However, few 
      researches investigated the influence of global pandemics on people at clinical 
      high risk (CHR) for psychosis. This study aimed to investigate the impact of the 
      COVID-19 pandemic on clinical symptoms, psychological distress, and eye-tracking 
      characteristics in CHR individuals and healthy participants. Forty-nine CHR 
      individuals and 50 healthy controls (HC) were assessed by PTSD Checklist for 
      DSM-5 (PCL-5), Perceived Stress Scale, 10-item version (PSS-10), and Coronavirus 
      Impact Scale (CIS). Eye movement performances were measured by the tests of 
      fixation stability, free-viewing, and anti-saccade. According to the mean score 
      of CIS, participants were stratified into high-impact (n = 35) and low-impact 
      (n = 64) subgroups. Compared with the HC group, CHR participants reported 
      significantly higher levels of post-traumatic symptoms caused by the COVID-19 
      pandemic and showed abnormalities in most of the eye movement indexes. Among the 
      altered indexes, the saccade amplitude of fixation stability test (far 
      distractor), the scan path length of free-viewing test, and the accuracy of 
      anti-saccade test were negatively affected by the severity of impact level in the 
      CHR group. Moreover, the altered eye movement indexes were significantly 
      associated with the total scores of CIS, PCL-5, and subscales of the Scale of 
      Prodromal Syndromes (SOPS) among CHR individuals. Overall, our findings suggested 
      the negative impact of the COVID-19 pandemic on the eye movement characteristics 
      of CHR individuals. The present study provides valuable information on 
      physiological distress related to the COVID-19 pandemic and sensitive 
      neuropsychological biomarkers that interacted with social and environment stress 
      in the CHR population.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Zhang, Dan
AU  - Zhang D
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
FAU - Guo, Qian
AU  - Guo Q
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China; 
      Department of Early Psychotic Disorders, Shanghai Mental Health Center, Shanghai 
      Jiao Tong University School of Medicine, Shanghai 200030, PR China. Electronic 
      address: guoqian1205@vip.163.com.
FAU - Xu, Lihua
AU  - Xu L
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
FAU - Liu, Xu
AU  - Liu X
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
FAU - Zhang, TianHong
AU  - Zhang T
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
FAU - Liu, Xiaohua
AU  - Liu X
AD  - Department of Early Psychotic Disorders, Shanghai Mental Health Center, Shanghai 
      Jiao Tong University School of Medicine, Shanghai 200030, PR China.
FAU - Chen, Haiying
AU  - Chen H
AD  - Department of Early Psychotic Disorders, Shanghai Mental Health Center, Shanghai 
      Jiao Tong University School of Medicine, Shanghai 200030, PR China.
FAU - Li, Guanjun
AU  - Li G
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China. 
      Electronic address: liguanjun66@126.com.
FAU - Wang, Jijun
AU  - Wang J
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, 
      Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China; CAS 
      Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), 
      Chinese Academy of Science, Shanghai 201203, PR China; Institute of Psychology 
      and Behavioral Science, Shanghai Jiao Tong University, Shanghai 200030, PR China. 
      Electronic address: jijunwang27@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220523
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB  - IM
MH  - *COVID-19/epidemiology
MH  - Eye-Tracking Technology
MH  - Humans
MH  - Pandemics
MH  - Prodromal Symptoms
MH  - *Psychotic Disorders/psychology
PMC - PMC9126616
OTO - NOTNLM
OT  - COVID-19
OT  - Clinical high-risk for psychosis
OT  - Eye movement
OT  - Psychological distress
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/27 06:00
MHDA- 2022/06/16 06:00
PMCR- 2022/05/23
CRDT- 2022/05/26 19:25
PHST- 2021/11/30 00:00 [received]
PHST- 2022/05/18 00:00 [revised]
PHST- 2022/05/19 00:00 [accepted]
PHST- 2022/05/27 06:00 [pubmed]
PHST- 2022/06/16 06:00 [medline]
PHST- 2022/05/26 19:25 [entrez]
PHST- 2022/05/23 00:00 [pmc-release]
AID - S0278-5846(22)00070-7 [pii]
AID - 110578 [pii]
AID - 10.1016/j.pnpbp.2022.110578 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2022 Aug 30;118:110578. doi: 
      10.1016/j.pnpbp.2022.110578. Epub 2022 May 23.