PMID- 35620383
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2057-7540 (Print)
IS  - 2057-7559 (Electronic)
IS  - 2057-7540 (Linking)
VI  - 8
DP  - 2022 Jan
TI  - Aortic Pulsatility Index: A New Haemodynamic Measure with Prognostic Value in 
      Advanced Heart Failure.
PG  - e18
LID - 10.15420/cfr.2022.09 [doi]
LID - e18
AB  - AIM: To test if the newly described haemodynamic variable, aortic pulsatility 
      index (API), predicts long-term prognosis in advanced heart failure (HF). 
      METHODS: A single-centre study on 453 HF patients (median age: 51 years; left 
      ventricular ejection fraction [LVEF]: 19% +/- 9%) referred for right heart 
      catheterisation. API was calculated as pulse pressure/pulmonary capillary wedge 
      pressure. RESULTS: Log(API) correlated significantly with central venous pressure 
      (CVP; p<0.001) and cardiac index (p<0.001) in univariable regression analysis. 
      CVP remained associated with log(API) in a multivariable analysis including 
      cardiac index, heart rate, log(NT-proBNP [N-terminal proB-type natriuretic 
      peptide]), LVEF, New York Heart Association (NYHA) class III or IV and sex 
      (p=0.01). In univariable Cox models, log(API) was a significant predictor of 
      freedom from the combined endpoint of death, left ventricular assist device 
      implantation, total artificial heart implantation or heart transplantation (HR 
      0.33; (95% CI [0.22-0.49]); p<0.001) and all-cause mortality (HR 0.56 (95% CI 
      [0.35-0.90]); p=0.015). After adjusting for age, sex, NYHA class III or IV and 
      estimated glomerular filtration rate in multivariable Cox models, log(API) 
      remained a significant predictor for the combined endpoint (HR 0.33; 95% CI 
      [0.20-0.56]; p<0.001) and all-cause mortality (HR 0.49; 95% CI [0.26-0.96]; 
      p=0.034). CONCLUSION: API was strongly associated with right-sided filling 
      pressure and independently predicted freedom from the combined endpoint and 
      all-cause mortality.
CI  - Copyright (c) 2022, Radcliffe Cardiology.
FAU - Deis, Tania
AU  - Deis T
AD  - Department of Cardiology, Rigshospitalet Copenhagen, Denmark.
FAU - Rossing, Kasper
AU  - Rossing K
AD  - Department of Cardiology, Rigshospitalet Copenhagen, Denmark.
FAU - Gustafsson, Finn
AU  - Gustafsson F
AD  - Department of Cardiology, Rigshospitalet Copenhagen, Denmark.
AD  - Department of Clinical Medicine, University of Copenhagen Denmark.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220516
PL  - England
TA  - Card Fail Rev
JT  - Cardiac failure review
JID - 101696210
PMC - PMC9127634
OTO - NOTNLM
OT  - Aortic pulsatility index
OT  - haemodynamics
OT  - heart failure with reduced ejection fraction
OT  - prognosis
COIS- Disclosure: KR has received fees from Abbott, AstraZeneca, Pfizer, Novartis, 
      Boehringer Ingelheim and Orion Pharma. FG has received research grants from the 
      Novo Nordisk Foundation (grant no NNF20OC0060561) and reports fees from Abbott, 
      AstraZeneca, Pfizer, Novartis, Boehringer Ingelheim, Pharmacosmos, Orion Pharma 
      and Alnylam, and is on the Cardiac Failure Review editorial board; this did not 
      influence peer review. TD has no conflicts of interest to declare. Ethics: The 
      study complies with the Declaration of Helsinki. The research protocol was 
      approved by the local research ethics committee (3-3013-1365/1) and the Data 
      Protection Agency (P-2020-1087). Informed Consent: Individual patient consent was 
      not required due to the retrospective nature of the study. Data Availability: The 
      data that support the findings of this study are available on request from the 
      corresponding author. The data are not publicly available because of privacy or 
      ethical restrictions. Author Contributions: Conception and design: FG, KR, TD. 
      Data extraction and data analysis: TD. All authors made a substantial 
      contribution to interpreting the data and writing the manuscript. All authors 
      reviewed and approved of the final manuscript before submission
EDAT- 2022/05/28 06:00
MHDA- 2022/05/28 06:01
PMCR- 2022/05/16
CRDT- 2022/05/27 02:28
PHST- 2022/01/27 00:00 [received]
PHST- 2022/02/27 00:00 [accepted]
PHST- 2022/05/27 02:28 [entrez]
PHST- 2022/05/28 06:00 [pubmed]
PHST- 2022/05/28 06:01 [medline]
PHST- 2022/05/16 00:00 [pmc-release]
AID - 10.15420/cfr.2022.09 [doi]
PST - epublish
SO  - Card Fail Rev. 2022 May 16;8:e18. doi: 10.15420/cfr.2022.09. eCollection 2022 
      Jan.