PMID- 35620847
OWN - NLM
STAT- MEDLINE
DCOM- 20220725
LR  - 20220729
IS  - 2162-3279 (Electronic)
VI  - 12
IP  - 7
DP  - 2022 Jul
TI  - Improved depressive symptoms in patients with refractory Gilles de la Tourette 
      syndrome after deep brain stimulation of posteroventral globus pallidus interna.
PG  - e2635
LID - 10.1002/brb3.2635 [doi]
LID - e2635
AB  - OBJECTIVE: Deep brain stimulation (DBS) has been used on drug-resistant Gilles de 
      la Tourette syndrome (GTS) for more than two decades until now, but the 
      stimulating targets are still under exploration until now. In this study, the 
      authors reported the efficacy of the bilateral posteroventral globus pallidus 
      interna (GPi) DBS on tic severity and neuropsychiatry symptoms of seven 
      individuals with GTS. METHOD: Seven patients with drug-resistant GTS were 
      enrolled in this study. The severity of these patients was evaluated with Yale 
      Global Tics Severity Scale (YGTSS), Yale Brown Obsessive Compulsive Scale 
      (YBOCS), Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale 
      (HAMA), and Global Assessment of Functioning Scale (GAF). Bilateral 
      posteroventral GPi were selected as the permanent stimulating targets. Follow-up 
      period was at least 5 years after surgery in the enrolled patients. RESULTS: 
      After surgery, one patient reported no improvement during the follow-up period, 
      and a device removal surgery was performed. The other six patients reported minor 
      to significant improvement. The overall YGTSS, YBOCS, HAMA HAMD, and GAF scores 
      of these patients were changed positively after surgery, but only the improvement 
      of the motor tic and HAMD scores had a statistical difference. No surgical 
      complication was reported. CONCLUSIONS: Bilateral posteroventral GPi DBS could 
      relieve the motor tics and depressive symptoms of the enrolled patients 
      significantly, but the vocal tics and other psychiatric symptoms presented a 
      progression without statistical difference during the follow-up period. The 
      results of this study suggested that bilateral posteroventral GPi are effective 
      targets for the motor tics in GTS patients, especially with prominent depressive 
      symptoms.
CI  - (c) 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Liu, Aijun
AU  - Liu A
AUID- ORCID: 0000-0001-7103-138X
AD  - Department of Neurosurgery, the Chinese PLA General Hospital, Haidian, Beijing, 
      China.
FAU - Jiao, Yongcheng
AU  - Jiao Y
AD  - Department of Neurosurgery, the Chinese PLA General Hospital, Haidian, Beijing, 
      China.
FAU - Zhang, Shaohui
AU  - Zhang S
AD  - Department of Neurosurgery, the Chinese PLA General Hospital, Haidian, Beijing, 
      China.
FAU - Kong, Haibo
AU  - Kong H
AD  - Department of Neurosurgery, the Chinese PLA General Hospital, Haidian, Beijing, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220527
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - *Deep Brain Stimulation/adverse effects/methods
MH  - Depression/etiology/therapy
MH  - Globus Pallidus
MH  - Humans
MH  - *Tics/etiology/therapy
MH  - *Tourette Syndrome/therapy
MH  - Treatment Outcome
PMC - PMC9304849
OTO - NOTNLM
OT  - Tourette syndrome
OT  - deep brain stimulation
OT  - internal globus pallidus
OT  - neuromodulation
COIS- The authors declare no conflict of interest, financial or otherwise.
EDAT- 2022/05/28 06:00
MHDA- 2022/07/26 06:00
PMCR- 2022/05/27
CRDT- 2022/05/27 03:14
PHST- 2022/01/29 00:00 [revised]
PHST- 2021/05/09 00:00 [received]
PHST- 2022/02/12 00:00 [accepted]
PHST- 2022/05/28 06:00 [pubmed]
PHST- 2022/07/26 06:00 [medline]
PHST- 2022/05/27 03:14 [entrez]
PHST- 2022/05/27 00:00 [pmc-release]
AID - BRB32635 [pii]
AID - 10.1002/brb3.2635 [doi]
PST - ppublish
SO  - Brain Behav. 2022 Jul;12(7):e2635. doi: 10.1002/brb3.2635. Epub 2022 May 27.