PMID- 35621139
OWN - NLM
STAT- MEDLINE
DCOM- 20220530
LR  - 20220716
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 26
IP  - 1
DP  - 2022 Jul
TI  - N‑acetyl cysteine prevents ambient fine particulate matter‑potentiated 
      atherosclerosis via inhibition of reactive oxygen species‑induced oxidized low 
      density lipoprotein elevation and decreased circulating endothelial progenitor 
      cell.
LID - 236 [pii]
LID - 10.3892/mmr.2022.12752 [doi]
AB  - Ambient fine particulate matter (PM) serves an important role in the development 
      of cardiovascular disease, including atherosclerosis. Antioxidant N‑acetyl 
      cysteine (NAC) has protective effects in the cardiovascular system. However, it 
      is unknown if NAC prevents PM‑potentiated atherosclerosis in hyperlipidemia. 
      Low‑density lipoprotein (LDL) receptor knockout mice were pretreated with 1 mg/ml 
      NAC in drinking water for 1 week and continued to receive NAC, high‑fat diet and 
      intranasal instillation of PM for 1 week or 6 months. Blood plasma was collected 
      for lipid profile, oxidized (ox‑)LDL, blood reactive oxygen species (ROS) and 
      inflammatory cytokine (TNF‑alpha, IL‑1beta and IL‑6) measurement. Blood cells were 
      harvested for endothelial progenitor cell (EPC) population and intracellular ROS 
      analysis. Murine aorta was isolated for atherosclerotic plaque ratio calculation. 
      NAC treatment maintained circulating EPC level and significantly decreased blood 
      ox‑LDL and ROS, inflammatory cytokines, mononuclear and EPC intracellular ROS 
      levels as well as aortic plaque ratio. NAC prevented PM‑potentiated 
      atherosclerosis by inhibiting plasma ROS‑induced ox‑LDL elevation, mononuclear 
      cell and EPC intracellular ROS‑induced circulating EPC reduction and inflammatory 
      cytokine production.
FAU - Xu, Yixin
AU  - Xu Y
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, Shandong 250021, P.R. China.
FAU - Bu, Haoran
AU  - Bu H
AD  - Department of Cardiology, Shandong Provincial Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250021, P.R. China.
FAU - Jiang, Yufan
AU  - Jiang Y
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, Shandong 250021, P.R. China.
FAU - Zhuo, Xiaoqing
AU  - Zhuo X
AD  - Department of Cardiology, Shandong Provincial Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250021, P.R. China.
FAU - Hu, Ke
AU  - Hu K
AD  - Department of Emergency, Qianfoshan Hospital, Shandong First Medical University, 
      Jinan, Shandong 250014, P.R. China.
FAU - Si, Zhihua
AU  - Si Z
AD  - Department of Emergency, Qianfoshan Hospital, Shandong First Medical University, 
      Jinan, Shandong 250014, P.R. China.
FAU - Chen, Yong
AU  - Chen Y
AD  - Department of Cardiology, Shandong Provincial Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong 250021, P.R. China.
FAU - Liu, Qiwei
AU  - Liu Q
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, Shandong 250021, P.R. China.
FAU - Gong, Xianwei
AU  - Gong X
AD  - Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First 
      Medical University, Jinan, Shandong 250021, P.R. China.
FAU - Sun, Haihui
AU  - Sun H
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, Shandong 250021, P.R. China.
FAU - Zhu, Qingyi
AU  - Zhu Q
AD  - Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South 
      University, Changsha, Hunan 410008, P.R. China.
FAU - Cui, Lianqun
AU  - Cui L
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, Shandong 250021, P.R. China.
FAU - Ma, Xiaochun
AU  - Ma X
AD  - Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to 
      Shandong First Medical University, Jinan, Shandong 250021, P.R. China.
FAU - Cui, Yuqi
AU  - Cui Y
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, Shandong 250021, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20220527
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Particulate Matter)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (oxidized low density lipoprotein)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/pharmacology
MH  - Animals
MH  - *Atherosclerosis/drug therapy
MH  - *Endothelial Progenitor Cells
MH  - Lipoproteins, LDL/pharmacology
MH  - Mice
MH  - Particulate Matter/toxicity
MH  - Reactive Oxygen Species
PMC - PMC9185698
OTO - NOTNLM
OT  - N‑acetyl cysteine
OT  - air pollution
OT  - endothelial progenitor cells
OT  - hyperlipidemia
OT  - inflammation
OT  - oxidized low density lipoprotein
OT  - particulate matter
OT  - reactive oxygen species
COIS- The authors declare that they have no competing interests.
EDAT- 2022/05/28 06:00
MHDA- 2022/05/31 06:00
PMCR- 2022/05/27
CRDT- 2022/05/27 06:42
PHST- 2022/03/11 00:00 [received]
PHST- 2022/05/09 00:00 [accepted]
PHST- 2022/05/27 06:42 [entrez]
PHST- 2022/05/28 06:00 [pubmed]
PHST- 2022/05/31 06:00 [medline]
PHST- 2022/05/27 00:00 [pmc-release]
AID - 236 [pii]
AID - MMR-26-01-12752 [pii]
AID - 10.3892/mmr.2022.12752 [doi]
PST - ppublish
SO  - Mol Med Rep. 2022 Jul;26(1):236. doi: 10.3892/mmr.2022.12752. Epub 2022 May 27.