PMID- 35621868
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2308-3425 (Electronic)
IS  - 2308-3425 (Linking)
VI  - 9
IP  - 5
DP  - 2022 May 13
TI  - Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 
      Diabetic Patients with Stable Coronary Artery Disease.
LID - 10.3390/jcdd9050157 [doi]
LID - 157
AB  - Background: We investigated whether serum levels of immunoglobin (Ig) E and 
      Nepsilon-carboxymethyl-lysine (CML) are related to in-stent restenosis (ISR) in 
      patients with stable coronary artery disease and type 2 diabetes mellitus (T2DM). 
      Methods: Serum levels of IgE and CML were measured in 196 ISR patients and 220 
      non-ISR patients with stable angina and T2DM who received angiographic follow-up 
      12 months after percutaneous coronary intervention (PCI) with third-generation 
      drug-eluting stent (DES) implantation for de novo lesions. Multivariate logistic 
      regression analysis was performed to assess the association between IgE or CML 
      and ISR. Results: Both IgE and CML levels were higher in patients with ISR 
      compared with non-ISR patients (IgE: 187.10 (63.75-489.65) vs. 80.25 
      (30.65-202.50), p < 0.001; CML: 203.26 (164.50-266.84) vs. 174.26 
      (130.85-215.56), p < 0.001). The rate of ISR increased stepwise with increasing 
      tertiles of IgE and CML levels (p for all trends < 0.001), and IgE correlated 
      significantly with CML. After adjusting for potential confounders, IgE and CML 
      levels remained independently associated with ISR. Moreover, IgE and CML levels 
      improved the predictive capability of traditional risk factors for ISR, and there 
      existed an interaction between IgE and CML in relation to ISR (p for interaction 
      < 0.01). Conclusion: Elevated circulating IgE and CML levels confer an increased 
      risk for ISR after DES-based PCI in type 2 diabetic patients with stable coronary 
      artery disease.
FAU - Liu, Jingmeng
AU  - Liu J
AUID- ORCID: 0000-0002-2218-9380
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Chen, Qiujing
AU  - Chen Q
AUID- ORCID: 0000-0002-5668-3774
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
AD  - Institute of Cardiovascular Diseases, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Lu, Lin
AU  - Lu L
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
AD  - Institute of Cardiovascular Diseases, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Jin, Qi
AU  - Jin Q
AUID- ORCID: 0000-0001-7683-072X
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Bao, Yangyang
AU  - Bao Y
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Ling, Tianyou
AU  - Ling T
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Lin, Changjian
AU  - Lin C
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Ding, Fenghua
AU  - Ding F
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Wang, Xiaoqun
AU  - Wang X
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Shen, Weifeng
AU  - Shen W
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
AD  - Institute of Cardiovascular Diseases, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Shen, Ying
AU  - Shen Y
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Dai, Yang
AU  - Dai Y
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
AD  - Institute of Cardiovascular Diseases, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
FAU - Wu, Liqun
AU  - Wu L
AD  - Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200025, China.
LA  - eng
GR  - 81870250/National Natural Science Foundation of China/
GR  - 81970362/National Natural Science Foundation of China/
GR  - 81970293/National Natural Science Foundation of China/
GR  - 81870357/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20220513
PL  - Switzerland
TA  - J Cardiovasc Dev Dis
JT  - Journal of cardiovascular development and disease
JID - 101651414
PMC - PMC9145878
OTO - NOTNLM
OT  - Nepsilon-carboxymethyl-lysine
OT  - diabetes
OT  - immunoglobulin E
OT  - in-stent restenosis
OT  - percutaneous coronary intervention
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/28 06:00
MHDA- 2022/05/28 06:01
PMCR- 2022/05/13
CRDT- 2022/05/27 10:23
PHST- 2022/04/15 00:00 [received]
PHST- 2022/05/11 00:00 [revised]
PHST- 2022/05/11 00:00 [accepted]
PHST- 2022/05/27 10:23 [entrez]
PHST- 2022/05/28 06:00 [pubmed]
PHST- 2022/05/28 06:01 [medline]
PHST- 2022/05/13 00:00 [pmc-release]
AID - jcdd9050157 [pii]
AID - jcdd-09-00157 [pii]
AID - 10.3390/jcdd9050157 [doi]
PST - epublish
SO  - J Cardiovasc Dev Dis. 2022 May 13;9(5):157. doi: 10.3390/jcdd9050157.