PMID- 35623489
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20220621
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 622
DP  - 2022 Jun 25
TI  - Novel microfluidic swirl mixers for scalable formulation of curcumin loaded 
      liposomes for cancer therapy.
PG  - 121857
LID - S0378-5173(22)00412-4 [pii]
LID - 10.1016/j.ijpharm.2022.121857 [doi]
AB  - Liposomes have been widely used in nanomedicine for the delivery of hydrophobic 
      and hydrophilic anticancer agents. The most common applications of these 
      formulations are vaccines and anticancer formulations (e.g., mRNA, small molecule 
      drugs). However, large-scale production with precise control of size and size 
      distribution of the lipid-based drug delivery systems (DDSs) is one of the major 
      challenges in the pharmaceutical industry. In this study, we used newly designed 
      microfluidic swirl mixers with simple 3D mixing chamber structures to prepare 
      liposomes at a larger scale (up to 320 mL/min or 20 L/h) than the commercially 
      available devices. This design demonstrated high productivity and better control 
      of liposome size and polydispersity index (PDI) than conventional liposome 
      preparation methods. The microfluidic swirl mixer devices were used to produce 
      curcumin-loaded liposomes under different processing conditions which were later 
      characterized and studied in vitro to evaluate their efficiency as DDSs. The 
      obtained results demonstrated that the liposomes can effectively deliver curcumin 
      into cancer cells. Therefore, the microfluidic swirl mixers are promising devices 
      for reproducible and scalable manufacturing of DDSs.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Xu, Ruicheng
AU  - Xu R
AD  - School of Pharmacy, Changzhou University, Changzhou 213164, China.
FAU - Tomeh, Mhd Anas
AU  - Tomeh MA
AD  - Department of Chemical and Biological Engineering, University of Sheffield, 
      Sheffield S1 3JD, UK.
FAU - Ye, Siyuan
AU  - Ye S
AD  - School of Pharmacy, Changzhou University, Changzhou 213164, China.
FAU - Zhang, Peng
AU  - Zhang P
AD  - School of Materials Science and Engineering, Changzhou University, Changzhou 
      213164, China.
FAU - Lv, Songwei
AU  - Lv S
AD  - School of Pharmacy, Changzhou University, Changzhou 213164, China.
FAU - You, Rongrong
AU  - You R
AD  - School of Pharmacy, Changzhou University, Changzhou 213164, China.
FAU - Wang, Nan
AU  - Wang N
AD  - School of Pharmacy, Changzhou University, Changzhou 213164, China.
FAU - Zhao, Xiubo
AU  - Zhao X
AD  - School of Pharmacy, Changzhou University, Changzhou 213164, China; Department of 
      Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, 
      UK. Electronic address: xiubo.zhao@cczu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220524
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Liposomes)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - *Curcumin
MH  - Drug Delivery Systems
MH  - Liposomes/chemistry
MH  - Microfluidics/methods
MH  - Nanomedicine
MH  - *Neoplasms
MH  - Particle Size
OTO - NOTNLM
OT  - Anticancer
OT  - Curcumin
OT  - Drug delivery system
OT  - Liposomes
OT  - Microfluidics
OT  - Size distribution
OT  - Swirl mixer
EDAT- 2022/05/28 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/05/27 19:25
PHST- 2022/01/01 00:00 [received]
PHST- 2022/05/18 00:00 [revised]
PHST- 2022/05/20 00:00 [accepted]
PHST- 2022/05/28 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/05/27 19:25 [entrez]
AID - S0378-5173(22)00412-4 [pii]
AID - 10.1016/j.ijpharm.2022.121857 [doi]
PST - ppublish
SO  - Int J Pharm. 2022 Jun 25;622:121857. doi: 10.1016/j.ijpharm.2022.121857. Epub 
      2022 May 24.