PMID- 35623824
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220608
IS  - 2405-4577 (Electronic)
IS  - 2405-4577 (Linking)
VI  - 49
DP  - 2022 Jun
TI  - Impact of probiotic supplementation in a patient with type 2 diabetes on glycemic 
      and lipid profile.
PG  - 264-269
LID - S2405-4577(22)00227-3 [pii]
LID - 10.1016/j.clnesp.2022.04.002 [doi]
AB  - BACKGROUND & AIMS: Type 2 diabetes mellitus (T2DM) is a progressive chronic 
      non-communicable disease associated with various comorbidities; it is considered 
      complex and therefore multifactorial strategies must be applied to reduce the 
      associated risks. The aim of this before-and-after clinical trial was to evaluate 
      the effects of adjuvant supplementation with probiotics in patients with T2DM. 
      METHODS: The study included 20 patients aged >30 years with T2DM who were 
      overweight or obese. The patients were administered probiotic supplements daily 
      for 90 days, which consisted of probiotics Bacillus clausii microorganism strain. 
      The patients' blood glucose parameters, lipid and intestinal microbiota profiles, 
      blood pressure (BP), drug therapy, body mass index (BMI), and food tissue were 
      evaluated. RESULTS: At the end of the study, we observed a statistically 
      significant difference in blood glucose, increased high density lipoprotein (HDL) 
      plasma levels, and improved intestinal microbiota profiles among the patients 
      included in this study. CONCLUSIONS: The results showed that probiotic 
      supplementation significantly reduced fasting glycemia and promoted an 
      improvement in their lipid profiles and intestinal health. These findings are 
      promising and the use of probiotics may be an appropriate adjuvant therapy for 
      glycemic control in patients with T2DM.
CI  - Copyright (c) 2022 European Society for Clinical Nutrition and Metabolism. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Ziegler, Maira Corneli
AU  - Ziegler MC
AD  - Programa de Pos-Graduacao Em Nutricao e Alimentos (PPGNA), Universidade Do Vale 
      Do Rio Dos Sinos, Sao Leopoldo, Zip code 93022-750, RS, Brazil. Electronic 
      address: mairacorneliziegler@hotmail.com.
FAU - Garbim Junior, Emilio Ernesto
AU  - Garbim Junior EE
AD  - Programa de Pos-Graduacao Em Nutricao e Alimentos (PPGNA), Universidade Do Vale 
      Do Rio Dos Sinos, Sao Leopoldo, Zip code 93022-750, RS, Brazil.
FAU - Jahnke, Viviane Schimitt
AU  - Jahnke VS
AD  - Escola da Saude, Universidade Do Vale Do Rio Dos Sinos, Sao Leopoldo, Zip code 
      93022-750, RS, Brazil.
FAU - Lisboa Moura, Josue Guilherme
AU  - Lisboa Moura JG
AD  - Programa de Pos-Graduacao Em Ciencias Farmaceuticas, Universidade Federal Do Rio 
      Grande Do Sul, Porto Alegre, Zip code 90610-000, RS, Brazil.
FAU - Brasil, Carolina Serpa
AU  - Brasil CS
AD  - Escola da Saude, Universidade Do Vale Do Rio Dos Sinos, Sao Leopoldo, Zip code 
      93022-750, RS, Brazil.
FAU - Schimitt da Cunha, Pedro Henrique
AU  - Schimitt da Cunha PH
AD  - Escola da Saude, Universidade Do Vale Do Rio Dos Sinos, Sao Leopoldo, Zip code 
      93022-750, RS, Brazil.
FAU - Lora, Priscila Schimitt
AU  - Lora PS
AD  - Programa de Pos-Graduacao Em Nutricao e Alimentos (PPGNA), Universidade Do Vale 
      Do Rio Dos Sinos, Sao Leopoldo, Zip code 93022-750, RS, Brazil; Escola da Saude, 
      Universidade Do Vale Do Rio Dos Sinos, Sao Leopoldo, Zip code 93022-750, RS, 
      Brazil.
FAU - Gemelli, Tanise
AU  - Gemelli T
AD  - Programa de Pos-Graduacao Em Nutricao e Alimentos (PPGNA), Universidade Do Vale 
      Do Rio Dos Sinos, Sao Leopoldo, Zip code 93022-750, RS, Brazil; Escola da Saude, 
      Universidade Do Vale Do Rio Dos Sinos, Sao Leopoldo, Zip code 93022-750, RS, 
      Brazil.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20220409
PL  - England
TA  - Clin Nutr ESPEN
JT  - Clinical nutrition ESPEN
JID - 101654592
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2/complications/therapy
MH  - Dietary Supplements
MH  - Humans
MH  - Lipids
MH  - *Probiotics/therapeutic use
OTO - NOTNLM
OT  - Bacillus clausii
OT  - Chronic diseases
OT  - Microbiot
OT  - Probiotic
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/05/28 06:00
MHDA- 2022/06/01 06:00
CRDT- 2022/05/27 21:07
PHST- 2021/10/05 00:00 [received]
PHST- 2022/03/22 00:00 [revised]
PHST- 2022/04/03 00:00 [accepted]
PHST- 2022/05/27 21:07 [entrez]
PHST- 2022/05/28 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
AID - S2405-4577(22)00227-3 [pii]
AID - 10.1016/j.clnesp.2022.04.002 [doi]
PST - ppublish
SO  - Clin Nutr ESPEN. 2022 Jun;49:264-269. doi: 10.1016/j.clnesp.2022.04.002. Epub 
      2022 Apr 9.