PMID- 35623837
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220608
IS  - 2405-4577 (Electronic)
IS  - 2405-4577 (Linking)
VI  - 49
DP  - 2022 Jun
TI  - Serum irisin levels in newly diagnosed type-II diabetic patients: No association 
      with the overall diet quality but strong association with fruit intake.
PG  - 357-364
LID - S2405-4577(22)00204-2 [pii]
LID - 10.1016/j.clnesp.2022.03.022 [doi]
AB  - OBJECTIVE: This study aimed to investigate the serum irisin levels and diet 
      quality of newly-diagnosed type 2 diabetes mellitus (T2DM) patients in comparison 
      with healthy controls and to identify the correlations between serum irisin 
      levels with diet quality, anthropometric measurements and biochemical parameters. 
      SUBJECTS/METHODS: This case-control study was conducted with 38 newly-diagnosed 
      T2DM patients and 38 healthy control individuals. Diet quality was calculated 
      from the semi-quantitative food frequency questionnaire by using the Healthy 
      Eating Index (HEI) 2015. The anthropometric measurements were taken and body 
      composition was analyzed with bioelectric impedance analysis (BIA) method. 
      Biochemical parameters and serum irisin levels were analyzed in blood samples 
      which were obtained after overnight fasting. RESULTS: Irisin levels were higher 
      in the T2DM group compared to the healthy control group (2.57 +/- 0.44 ng/mL and 
      2.15 +/- 0.44 ng/mL, respectively; p < 0.001). The optimal cut-off value for irisin 
      to predict T2DM was 2.195 ng/mL (specificity = 71.1%, sensitivity = 78.9%). In 
      both groups, irisin levels were not associated with overall HEI 2015; however, 
      they were positively associated with total and whole fruit scores in the T2DM 
      group (p < 0.05). After adjustment according to age, sex and BMI, in the T2DM 
      group HDL cholesterol positively affected by irisin levels, while in the control 
      group triglyceride positively affected irisin levels (p < 0.05). CONCLUSION: High 
      levels of irisin in newly diagnosed T2DM patients compared to healthy individuals 
      indicate that irisin may have a role in the monitoring and treatment of T2DM. 
      Though irisin levels were not associated with total diet quality, they were 
      associated with fruit consumption.
CI  - Copyright (c) 2022 European Society for Clinical Nutrition and Metabolism. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Yildiz Kopuz, Tuba N
AU  - Yildiz Kopuz TN
AD  - Hacettepe University, Faculty of Health Sciences, Department of Nutrition and 
      Dietetics, Ankara, Turkey. Electronic address: tubanuryildiz@hacettepe.edu.tr.
FAU - Dagdeviren, Murat
AU  - Dagdeviren M
AD  - Kecioren Training and Research Hospital, Department of Endocrinology, Ankara, 
      Turkey.
FAU - Fisunoglu, Mehmet
AU  - Fisunoglu M
AD  - Hacettepe University, Faculty of Health Sciences, Department of Nutrition and 
      Dietetics, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220323
PL  - England
TA  - Clin Nutr ESPEN
JT  - Clinical nutrition ESPEN
JID - 101654592
RN  - 0 (Fibronectins)
SB  - IM
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2
MH  - Fasting
MH  - *Fibronectins
MH  - Fruit
MH  - Humans
OTO - NOTNLM
OT  - Body fat
OT  - Diet quality
OT  - HDL cholesterol
OT  - Irisin
OT  - Type 2 diabetes
COIS- Declaration of competing interest The authors have no conflict of interest.
EDAT- 2022/05/28 06:00
MHDA- 2022/06/01 06:00
CRDT- 2022/05/27 21:07
PHST- 2021/12/10 00:00 [received]
PHST- 2022/03/05 00:00 [revised]
PHST- 2022/03/15 00:00 [accepted]
PHST- 2022/05/27 21:07 [entrez]
PHST- 2022/05/28 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
AID - S2405-4577(22)00204-2 [pii]
AID - 10.1016/j.clnesp.2022.03.022 [doi]
PST - ppublish
SO  - Clin Nutr ESPEN. 2022 Jun;49:357-364. doi: 10.1016/j.clnesp.2022.03.022. Epub 
      2022 Mar 23.