PMID- 35624570
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 2079-6374 (Electronic)
IS  - 2079-6374 (Linking)
VI  - 12
IP  - 5
DP  - 2022 Apr 24
TI  - Properties and Applications of Graphene and Its Derivatives in Biosensors for 
      Cancer Detection: A Comprehensive Review.
LID - 10.3390/bios12050269 [doi]
LID - 269
AB  - Cancer is one of the deadliest diseases worldwide, and there is a critical need 
      for diagnostic platforms for applications in early cancer detection. The 
      diagnosis of cancer can be made by identifying abnormal cell characteristics such 
      as functional changes, a number of vital proteins in the body, abnormal genetic 
      mutations and structural changes, and so on. Identifying biomarker candidates 
      such as DNA, RNA, mRNA, aptamers, metabolomic biomolecules, enzymes, and proteins 
      is one of the most important challenges. In order to eliminate such challenges, 
      emerging biomarkers can be identified by designing a suitable biosensor. One of 
      the most powerful technologies in development is biosensor technology based on 
      nanostructures. Recently, graphene and its derivatives have been used for diverse 
      diagnostic and therapeutic approaches. Graphene-based biosensors have exhibited 
      significant performance with excellent sensitivity, selectivity, stability, and a 
      wide detection range. In this review, the principle of technology, advances, and 
      challenges in graphene-based biosensors such as field-effect transistors (FET), 
      fluorescence sensors, SPR biosensors, and electrochemical biosensors to detect 
      different cancer cells is systematically discussed. Additionally, we provide an 
      outlook on the properties, applications, and challenges of graphene and its 
      derivatives, such as Graphene Oxide (GO), Reduced Graphene Oxide (RGO), and 
      Graphene Quantum Dots (GQDs), in early cancer detection by nanobiosensors.
FAU - Pourmadadi, Mehrab
AU  - Pourmadadi M
AD  - School of Chemical Engineering, College of Engineering, University of Tehran, 
      Tehran 1417935840, Iran.
FAU - Soleimani Dinani, Homayoon
AU  - Soleimani Dinani H
AD  - Department of Electrical and Computer Engineering, Missouri University of Science 
      and Technology, Rolla, MO 65409, USA.
FAU - Saeidi Tabar, Fatemeh
AU  - Saeidi Tabar F
AD  - School of Chemical Engineering, College of Engineering, University of Tehran, 
      Tehran 1417935840, Iran.
FAU - Khassi, Kajal
AU  - Khassi K
AD  - Department of Textile Engineering, Isfahan University of Technology, Isfahan 
      8415683111, Iran.
FAU - Janfaza, Sajjad
AU  - Janfaza S
AD  - School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, 
      Canada.
FAU - Tasnim, Nishat
AU  - Tasnim N
AUID- ORCID: 0000-0002-9899-2014
AD  - School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, 
      Canada.
AD  - School of Engineering and Computer Science, University of Victoria, Victoria, BC 
      V8W 2Y2, Canada.
FAU - Hoorfar, Mina
AU  - Hoorfar M
AD  - School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, 
      Canada.
AD  - School of Engineering and Computer Science, University of Victoria, Victoria, BC 
      V8W 2Y2, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220424
PL  - Switzerland
TA  - Biosensors (Basel)
JT  - Biosensors
JID - 101609191
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - *Biosensing Techniques
MH  - Early Detection of Cancer
MH  - *Graphite
MH  - *Nanostructures
MH  - *Neoplasms/diagnosis
MH  - *Quantum Dots
PMC - PMC9138779
OTO - NOTNLM
OT  - biosensing method
OT  - cancer biomarkers
OT  - diagnostic applications
OT  - graphene
OT  - nanobiosensor
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/04/24
CRDT- 2022/05/28 01:01
PHST- 2022/02/10 00:00 [received]
PHST- 2022/04/11 00:00 [revised]
PHST- 2022/04/14 00:00 [accepted]
PHST- 2022/05/28 01:01 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/04/24 00:00 [pmc-release]
AID - bios12050269 [pii]
AID - biosensors-12-00269 [pii]
AID - 10.3390/bios12050269 [doi]
PST - epublish
SO  - Biosensors (Basel). 2022 Apr 24;12(5):269. doi: 10.3390/bios12050269.