PMID- 35624906
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 12
IP  - 5
DP  - 2022 Apr 20
TI  - Characterization of Macular Structural and Microvascular Changes in Thalamic 
      Infarction Patients: A Swept-Source Optical Coherence Tomography-Angiography 
      Study.
LID - 10.3390/brainsci12050518 [doi]
LID - 518
AB  - Background: The retina and brain share similar neuronal and microvascular 
      features. We aimed to investigate the retinal thickness and microvasculature in 
      patients with thalamic infarcts compared with control participants. Material and 
      methods: Swept-source optical coherence tomography (SS-OCT) was used to image the 
      macular thickness (retinal nerve fiber layer, RNFL; ganglion cell-inner plexiform 
      layer, GCIP), while OCT angiography was used to image the microvasculature 
      (superficial vascular plexus, SVP; intermediate capillary plexus, ICP; deep 
      capillary plexus, DCP). Inbuilt software was used to measure the macular 
      thickness (microm) and microvascular density (%). Lesion volumes were quantitively 
      assessed based on structural magnetic resonance images. Results: A total of 35 
      patients with unilateral thalamic infarction and 31 age-sex-matched controls were 
      enrolled. Compared with control participants, thalamic infarction patients showed 
      a significantly thinner thickness of RNFL (p < 0.01) and GCIP (p = 0.02), and a 
      lower density of SVP (p = 0.001) and ICP (p = 0.022). In the group of patients, 
      ipsilateral eyes showed significant reductions in SVP (p = 0.033), RNFL (p = 
      0.01) and GCIP (p = 0.043). When divided into three groups based on disease 
      duration (<1 month, 1-6 months, and >6 months), no significant differences were 
      found among these groups. After adjusting for confounders, SVP, ICP, DCP, RNFL, 
      and GCIP were significantly correlated with lesion volume in patients. 
      Conclusions: Thalamic infarction patients showed significant macular structure 
      and microvasculature changes. Lesion size was significantly correlated with these 
      alterations. These findings may be useful for further research into the clinical 
      utility of retinal imaging in stroke patients, especially those with damage to 
      the visual pathway.
FAU - Ye, Chen
AU  - Ye C
AUID- ORCID: 0000-0003-2969-5486
AD  - Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue 
      Lane, Chengdu 610041, China.
FAU - Kwapong, William Robert
AU  - Kwapong WR
AUID- ORCID: 0000-0001-9633-4694
AD  - Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue 
      Lane, Chengdu 610041, China.
FAU - Tao, Wendan
AU  - Tao W
AD  - Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue 
      Lane, Chengdu 610041, China.
FAU - Lu, Kun
AU  - Lu K
AD  - Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue 
      Lane, Chengdu 610041, China.
FAU - Pan, Ruosu
AU  - Pan R
AD  - Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue 
      Lane, Chengdu 610041, China.
FAU - Wang, Anmo
AU  - Wang A
AD  - Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue 
      Lane, Chengdu 610041, China.
FAU - Liu, Junfeng
AU  - Liu J
AD  - Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue 
      Lane, Chengdu 610041, China.
FAU - Liu, Ming
AU  - Liu M
AD  - Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue 
      Lane, Chengdu 610041, China.
FAU - Wu, Bo
AU  - Wu B
AD  - Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue 
      Lane, Chengdu 610041, China.
LA  - eng
GR  - 2021-YF05- 01325-SN/the Technology Innovation R&amp;D Project of Chengdu Science 
      and Technology Bureau/
GR  - 81870937, 82071320, 81901199/National Natural Science Foundation of China/
GR  - ZYGD18009/the 1.3.5 project for disciplines of excellence, West China Hospital, 
      Sichuan University/
PT  - Journal Article
DEP - 20220420
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC9139152
OTO - NOTNLM
OT  - SS-OCT/OCTA
OT  - ischemic stroke
OT  - macula
OT  - microvasculature
OT  - thalamic infarction
COIS- The authors have no conflicts of interest to declare.
EDAT- 2022/05/29 06:00
MHDA- 2022/05/29 06:01
PMCR- 2022/04/20
CRDT- 2022/05/28 01:03
PHST- 2022/03/07 00:00 [received]
PHST- 2022/04/02 00:00 [revised]
PHST- 2022/04/17 00:00 [accepted]
PHST- 2022/05/28 01:03 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/05/29 06:01 [medline]
PHST- 2022/04/20 00:00 [pmc-release]
AID - brainsci12050518 [pii]
AID - brainsci-12-00518 [pii]
AID - 10.3390/brainsci12050518 [doi]
PST - epublish
SO  - Brain Sci. 2022 Apr 20;12(5):518. doi: 10.3390/brainsci12050518.