PMID- 35625542
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 12
IP  - 5
DP  - 2022 Apr 21
TI  - Roles of mTOR in the Regulation of Pancreatic beta-Cell Mass and Insulin Secretion.
LID - 10.3390/biom12050614 [doi]
LID - 614
AB  - Pancreatic beta-cells are the only type of cells that can control glycemic levels 
      via insulin secretion. Thus, to explore the mechanisms underlying pancreatic 
      beta-cell failure, many reports have clarified the roles of important molecules, 
      such as the mechanistic target of rapamycin (mTOR), which is a central regulator 
      of metabolic and nutrient cues. Studies have uncovered the roles of mTOR in the 
      function of beta-cells and the progression of diabetes, and they suggest that mTOR 
      has both positive and negative effects on pancreatic beta-cells in the development 
      of diabetes.
FAU - Asahara, Shun-Ichiro
AU  - Asahara SI
AD  - Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe 
      University Graduate School of Medicine, Kobe 6500017, Japan.
FAU - Inoue, Hiroyuki
AU  - Inoue H
AD  - Division of Medical Chemistry, Department of Metabolism and Diseases, Kobe 
      University Graduate School of Health Sciences, Kobe 6540142, Japan.
FAU - Watanabe, Hitoshi
AU  - Watanabe H
AD  - Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia 
      University, New York, NY 10032, USA.
AD  - Naomi Berrie Diabetes Center, Vagelos College of Physicians and Surgeons, 
      Columbia University, New York, NY 10032, USA.
FAU - Kido, Yoshiaki
AU  - Kido Y
AD  - Division of Medical Chemistry, Department of Metabolism and Diseases, Kobe 
      University Graduate School of Health Sciences, Kobe 6540142, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220421
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - *Diabetes Mellitus/metabolism
MH  - Humans
MH  - Insulin Secretion
MH  - *Insulin-Secreting Cells/metabolism
MH  - Sirolimus/metabolism
MH  - TOR Serine-Threonine Kinases/metabolism
PMC - PMC9138643
OTO - NOTNLM
OT  - ER stress
OT  - autophagy
OT  - insulin secretion
OT  - mTOR
OT  - pancreatic beta-cell
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/04/21
CRDT- 2022/05/28 01:06
PHST- 2022/03/02 00:00 [received]
PHST- 2022/03/28 00:00 [revised]
PHST- 2022/03/29 00:00 [accepted]
PHST- 2022/05/28 01:06 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/04/21 00:00 [pmc-release]
AID - biom12050614 [pii]
AID - biomolecules-12-00614 [pii]
AID - 10.3390/biom12050614 [doi]
PST - epublish
SO  - Biomolecules. 2022 Apr 21;12(5):614. doi: 10.3390/biom12050614.