PMID- 35625601
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 12
IP  - 5
DP  - 2022 May 6
TI  - Loricrin at the Boundary between Inside and Outside.
LID - 10.3390/biom12050673 [doi]
LID - 673
AB  - Cornification is a specialized mode of the cell-death program exclusively allowed 
      for terrestrial amniotes. Recent investigations suggest that loricrin (LOR) is an 
      important cornification effector. As the connotation of its name ("lorica" 
      meaning an armor in Latin) suggests, the keratin-associated protein LOR promotes 
      the maturation of the epidermal structure through organizing covalent 
      cross-linkages, endowing the epidermis with the protection against oxidative 
      injuries. By reviewing cornification mechanisms, we seek to classify 
      ichthyosiform dermatoses based on their function, rather than clinical 
      manifestations. We also reviewed recent mechanistic insights into the Kelch-like 
      erythroid cell-derived protein with the cap "n" collar homology-associated 
      protein 1/nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway in 
      skin health and diseases, as LOR and NRF2 coordinate the epidermis-intrinsic 
      xenobiotic metabolism. Finally, we refine the theoretical framework of 
      cross-talking between keratinocytes and epidermal resident leukocytes, dissecting 
      an LOR immunomodulatory function.
FAU - Ishitsuka, Yosuke
AU  - Ishitsuka Y
AUID- ORCID: 0000-0002-1733-5427
AD  - Department of Dermatology Integrated Medicine, Osaka University Graduate School 
      of Medicine, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan.
FAU - Roop, Dennis R
AU  - Roop DR
AD  - Department of Dermatology and Charles C. Gates Center for Regenerative Medicine, 
      University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220506
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Membrane Proteins)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (loricrin)
SB  - IM
MH  - Epidermis/metabolism
MH  - Keratinocytes/metabolism
MH  - *Membrane Proteins/metabolism
MH  - *NF-E2-Related Factor 2/metabolism
PMC - PMC9138667
OTO - NOTNLM
OT  - Langerhans cell
OT  - TGF-beta
OT  - ichthyosis
OT  - loricrin
OT  - oxidation
OT  - reduction
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/05/06
CRDT- 2022/05/28 01:06
PHST- 2022/04/13 00:00 [received]
PHST- 2022/04/30 00:00 [revised]
PHST- 2022/05/04 00:00 [accepted]
PHST- 2022/05/28 01:06 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/05/06 00:00 [pmc-release]
AID - biom12050673 [pii]
AID - biomolecules-12-00673 [pii]
AID - 10.3390/biom12050673 [doi]
PST - epublish
SO  - Biomolecules. 2022 May 6;12(5):673. doi: 10.3390/biom12050673.