PMID- 35625662
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 12
IP  - 5
DP  - 2022 May 23
TI  - Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical 
      Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats.
LID - 10.3390/biom12050735 [doi]
LID - 735
AB  - Homocysteine is a sulfur-containing endogenous amino acid leading to neurotoxic 
      effects at high concentrations. Population studies suggest an association between 
      plasma homocysteine levels and the risk of migraine headaches. The aim of this 
      study was to analyze the sensitivity of rats with prenatal hyperhomocysteinemia 
      (hHCY) in respect of the development of behavioral correlates of headache and 
      spreading cortical depolarization (CSD) in a migraine model induced by the 
      administration of the nitric oxide (NO) donor nitroglycerin. Animals with hHCY 
      were characterized by migraine-related symptoms such as mechanical hyperalgesia, 
      high-level anxiety, photophobia, as well as an enhanced level of neuronal 
      activity in the somatosensory cortex along with a lower threshold of CSD 
      generation. Likewise, acute or chronic intermittent administration of 
      nitroglycerin also induced the development of mechanical allodynia, photophobia 
      and anxiety in control groups. However, these symptoms were more pronounced in 
      rats with hHCY. Unlike hHCY, nitroglycerin administration did not affect the 
      threshold of CSD generation, but like hHCY, increased the background neuronal 
      activity in layers 2/3 and 4 of the cerebral cortex. The latter was more 
      pronounced in animals with hHCY. Thus, the migraine profile associated with hHCY 
      can be further exaggerated in conditions with enhanced levels of migraine 
      triggering the gaseous transmitter NO. Our data are consistent with the view that 
      high levels of plasma homocysteine can act as a risk factor for the development 
      of migraine.
FAU - Gerasimova, Elena
AU  - Gerasimova E
AUID- ORCID: 0000-0002-0623-8496
AD  - Department of Human and Animal Physiology, Institute of Fundamental Medicine and 
      Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.
AD  - Department of Neurobiology, Sirius University of Science and Technology, 1 
      Olympic Ave., 353340 Sochi, Russia.
FAU - Yakovleva, Olga
AU  - Yakovleva O
AD  - Department of Human and Animal Physiology, Institute of Fundamental Medicine and 
      Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.
FAU - Enikeev, Daniel
AU  - Enikeev D
AUID- ORCID: 0000-0002-6998-6651
AD  - Department of Human and Animal Physiology, Institute of Fundamental Medicine and 
      Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.
FAU - Bogatova, Ksenia
AU  - Bogatova K
AUID- ORCID: 0000-0002-5711-2439
AD  - Department of Human and Animal Physiology, Institute of Fundamental Medicine and 
      Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.
FAU - Hermann, Anton
AU  - Hermann A
AD  - Department of Biosciences, University of Salzburg, 5020 Salzburg, Austria.
FAU - Giniatullin, Rashid
AU  - Giniatullin R
AD  - A.I Virtanen Institute, University of Eastern Finland, FI-70211 Kuopio, Finland.
FAU - Sitdikova, Guzel
AU  - Sitdikova G
AUID- ORCID: 0000-0001-5412-2204
AD  - Department of Human and Animal Physiology, Institute of Fundamental Medicine and 
      Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220523
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - G59M7S0WS3 (Nitroglycerin)
SB  - IM
MH  - Animals
MH  - Anxiety
MH  - *Cortical Excitability
MH  - Female
MH  - Homocysteine
MH  - Hyperalgesia/chemically induced
MH  - *Hyperhomocysteinemia/chemically induced/complications/metabolism
MH  - *Migraine Disorders/chemically induced
MH  - Nitroglycerin/toxicity
MH  - Photophobia
MH  - Pregnancy
MH  - Rats
PMC - PMC9138593
OTO - NOTNLM
OT  - allodynia
OT  - anxiety
OT  - cortical excitability
OT  - cortical spreading depression
OT  - hyperhomocysteinemia
OT  - migraine
OT  - nitroglycerine
OT  - photophobia
COIS- The authors declare no competing interests.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/05/23
CRDT- 2022/05/28 01:07
PHST- 2022/03/28 00:00 [received]
PHST- 2022/05/10 00:00 [revised]
PHST- 2022/05/17 00:00 [accepted]
PHST- 2022/05/28 01:07 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/05/23 00:00 [pmc-release]
AID - biom12050735 [pii]
AID - biomolecules-12-00735 [pii]
AID - 10.3390/biom12050735 [doi]
PST - epublish
SO  - Biomolecules. 2022 May 23;12(5):735. doi: 10.3390/biom12050735.