PMID- 35626260
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 12
IP  - 5
DP  - 2022 Apr 28
TI  - Comparison of Nonclassic and Classic Phenotype of Hypertrophic Cardiomyopathy 
      Focused on Prognostic Cardiac Magnetic Resonance Parameters: A Single-Center 
      Observational Study.
LID - 10.3390/diagnostics12051104 [doi]
LID - 1104
AB  - Patients with nonclassic phenotypes (NCP)-more advanced stages of hypertrophic 
      cardiomyopathy (HCM)-constitute an intriguing and heterogeneous group that is 
      difficult to diagnose, risk-stratify, and treat, and often neglected in research 
      projects. We aimed to compare cardiac magnetic resonance (CMR) parameters in NCP 
      versus classic phenotypes (CP) of HCM with special emphasis given to the 
      parameters of established and potential prognostic importance, including numerous 
      variables not used in everyday clinical practice. The CMR studies of 88 patients 
      performed from 2011 to 2019 were postprocessed according to the study protocol to 
      obtain standard and non-standard parameters. In NCP, the late gadolinium 
      enhancement extent expressed as percent of left ventricular mass (%LGE) and left 
      ventricular mass index (LVMI) were higher, left atrium emptying fraction (LAEF) 
      was lower, minimal left atrial volume (LAV min) was greater, and myocardial 
      contraction fraction (MCF) and left ventricular global function index (LVGFI) 
      were lower than in CP (p < 0.001 for all). In contrast, HCM risk score and left 
      ventricular maximal thickness (LVMT) were similar in NCP and CP patients. No left 
      ventricular outflow tract obstruction (LVOTO) was observed in the NCP group. Left 
      ventricular outflow tract diameter (LVOT), aortic valve diameter (Ao), and 
      LVOT/Ao ratio were significantly higher and anterior mitral leaflet (AML)/LVOT 
      ratio was lower in the NCP compared to the CP group. In conclusion, significant 
      differences in nonstandard CMR parameters were noted between the nonclassic and 
      classic HCM phenotypes that may contribute to future studies on disease stages 
      and risk stratification in HCM.
FAU - Stachera, Magdalena
AU  - Stachera M
AUID- ORCID: 0000-0001-9181-5878
AD  - Clinical Department of Diagnostic Imaging, Institute of Medical Sciences, 
      University of Opole, 45-052 Opole, Poland.
FAU - Przybylo, Pawel
AU  - Przybylo P
AD  - Department of Cardiology, University Hospital in Opole, 45-401 Opole, Poland.
FAU - Sznajder, Katarzyna
AU  - Sznajder K
AD  - Clinical Department of Diagnostic Imaging, Institute of Medical Sciences, 
      University of Opole, 45-052 Opole, Poland.
FAU - Gierlotka, Marek
AU  - Gierlotka M
AUID- ORCID: 0000-0001-5639-2128
AD  - Department of Cardiology, Institute of Medical Sciences, University of Opole, 
      45-401 Opole, Poland.
LA  - eng
GR  - Project number: P-2021-004./Institute of Medical Sciences, University of Opole, 
      Poland/
PT  - Journal Article
DEP - 20220428
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC9139797
OTO - NOTNLM
OT  - functional imaging
OT  - hypertrophic cardiomyopathy
OT  - late gadolinium enhancement
OT  - left atrium
OT  - left ventricular obstruction
OT  - magnetic resonance imaging
OT  - mitral valve apparatus
OT  - new imaging techniques
OT  - outcomes
OT  - phenotype
OT  - prognosis
OT  - sudden cardiac death
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/05/29 06:01
PMCR- 2022/04/28
CRDT- 2022/05/28 01:10
PHST- 2022/03/31 00:00 [received]
PHST- 2022/04/25 00:00 [revised]
PHST- 2022/04/26 00:00 [accepted]
PHST- 2022/05/28 01:10 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/05/29 06:01 [medline]
PHST- 2022/04/28 00:00 [pmc-release]
AID - diagnostics12051104 [pii]
AID - diagnostics-12-01104 [pii]
AID - 10.3390/diagnostics12051104 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2022 Apr 28;12(5):1104. doi: 10.3390/diagnostics12051104.