PMID- 35626743
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 11
IP  - 10
DP  - 2022 May 20
TI  - Central Nervous System Pericytes Contribute to Health and Disease.
LID - 10.3390/cells11101707 [doi]
LID - 1707
AB  - Successful neuroprotection is only possible with contemporary microvascular 
      protection. The prevention of disease-induced vascular modifications that 
      accelerate brain damage remains largely elusive. An improved understanding of 
      pericyte (PC) signalling could provide important insight into the function of the 
      neurovascular unit (NVU), and into the injury-provoked responses that modify 
      cell-cell interactions and crosstalk. Due to sharing the same basement membrane 
      with endothelial cells, PCs have a crucial role in the control of endothelial, 
      astrocyte, and oligodendrocyte precursor functions and hence blood-brain barrier 
      stability. Both cerebrovascular and neurodegenerative diseases impair oxygen 
      delivery and functionally impair the NVU. In this review, the role of PCs in 
      central nervous system health and disease is discussed, considering their origin, 
      multipotency, functions and also dysfunction, focusing on new possible avenues to 
      modulate neuroprotection. Dysfunctional PC signalling could also be considered as 
      a potential biomarker of NVU pathology, allowing us to individualize therapeutic 
      interventions, monitor responses, or predict outcomes.
FAU - Girolamo, Francesco
AU  - Girolamo F
AUID- ORCID: 0000-0001-8706-3386
AD  - Unit of Human Anatomy and Histology, Department of Basic Medical Sciences, 
      Neuroscience and Sense Organs, University of Bari 'Aldo Moro', 70124 Bari, Italy.
FAU - Errede, Mariella
AU  - Errede M
AD  - Unit of Human Anatomy and Histology, Department of Basic Medical Sciences, 
      Neuroscience and Sense Organs, University of Bari 'Aldo Moro', 70124 Bari, Italy.
FAU - Bizzoca, Antonella
AU  - Bizzoca A
AD  - Physiology Unit, Department of Basic Medical Sciences, Neuroscience and Sense 
      Organs, University of Bari 'Aldo Moro', 70124 Bari, Italy.
FAU - Virgintino, Daniela
AU  - Virgintino D
AD  - Unit of Human Anatomy and Histology, Department of Basic Medical Sciences, 
      Neuroscience and Sense Organs, University of Bari 'Aldo Moro', 70124 Bari, Italy.
FAU - Ribatti, Domenico
AU  - Ribatti D
AUID- ORCID: 0000-0003-4768-8431
AD  - Unit of Human Anatomy and Histology, Department of Basic Medical Sciences, 
      Neuroscience and Sense Organs, University of Bari 'Aldo Moro', 70124 Bari, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220520
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
SB  - IM
MH  - Astrocytes
MH  - Blood-Brain Barrier/pathology
MH  - Cell Communication
MH  - *Endothelial Cells/physiology
MH  - *Pericytes/pathology
PMC - PMC9139243
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - angiogenesis
OT  - mesoangioblast
OT  - multiple sclerosis
OT  - neuroCOVID-19
OT  - neurodevelopmental disorders
OT  - neuroinflammation
OT  - neurovascular unit
OT  - stroke
COIS- The authors declare that they have no competing interests.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/05/20
CRDT- 2022/05/28 01:13
PHST- 2022/04/28 00:00 [received]
PHST- 2022/05/16 00:00 [revised]
PHST- 2022/05/18 00:00 [accepted]
PHST- 2022/05/28 01:13 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/05/20 00:00 [pmc-release]
AID - cells11101707 [pii]
AID - cells-11-01707 [pii]
AID - 10.3390/cells11101707 [doi]
PST - epublish
SO  - Cells. 2022 May 20;11(10):1707. doi: 10.3390/cells11101707.