PMID- 35626838
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 9
IP  - 5
DP  - 2022 May 4
TI  - Association between Serum Total and Specific Immunoglobulin E Levels and Body 
      Height: A Cross-Sectional Study of Children and Adolescents.
LID - 10.3390/children9050661 [doi]
LID - 661
AB  - Background: The atopy rate in children has increased significantly. Atopy and 
      growth are connected in a multifactorial manner and are important health issues 
      for children around the world. The principal research question in this 
      cross-sectional investigation concerned the association between serum total, 
      specific immunoglobulin E (IgE) levels, and body height (BH)/weight (BW)/body 
      mass index (BMI). Methods: A total of 993 subjects were enrolled for analysis 
      retrospectively with allergic diseases and aged from 6 months to 18 years during 
      the years 2015-2016. A complete panel of 36 allergen-specific IgE was taken from 
      each participant using the MAST allergen test as well as their BH, BW, BMI, and 
      total IgE levels. Results: There was a statistically significant positive 
      association between the total IgE levels with BH (N = 348) and BW (N = 623) in 
      the preschool age group (<6 years old, p-values of 0.009 and 0.034, 
      respectively). In the preschool group, the total IgE levels showed a positive 
      association with house dust (p < 0.001), cockroach mix (p < 0.001), 
      Dermatophagoides farina (p < 0.001), and Dermatophagoides pteronyssinus (p < 
      0.001). After performing a general linear model followed by a backward selection 
      of variables with age, sex, specific IgE, and total IgE, egg white sensitization 
      demonstrated a significant negative association with BH (p = 0.009), and 
      Dermatophagoides farina sensitization showed a significant positive association 
      with BH (p = 0.006). The analysis showed that, in this model, the level of total 
      IgE was not associated with BH. Conclusions: The results of this study indicate 
      that the level of total IgE was not associated with BH in the preschool age 
      group. Future studies are needed to replicate the results in outcome with 
      follow-up allergic cohorts.
FAU - Chang, Ling-Sai
AU  - Chang LS
AD  - Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
AD  - College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
FAU - Li, Jou-Hui
AU  - Li JH
AD  - Department of Family Medicine, Chang Gung Memorial Hospital, Kaohsiung 83301, 
      Taiwan.
FAU - Wang, Pei-Ming
AU  - Wang PM
AD  - Department of Family Medicine, Chang Gung Memorial Hospital, Kaohsiung 83301, 
      Taiwan.
FAU - Huang, Chih-Fang
AU  - Huang CF
AD  - Department of Family Medicine, Chang Gung Memorial Hospital, Kaohsiung 83301, 
      Taiwan.
FAU - Kuo, Ho-Chang
AU  - Kuo HC
AUID- ORCID: 0000-0002-3295-2984
AD  - Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
AD  - College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
AD  - Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, 
      Kaohsiung 83301, Taiwan.
LA  - eng
GR  - 108-2314-B-182 -037 -MY3/Ministry of Science and Technology of Taiwan/
GR  - 8E0212, CMRPG8L0021, CORPG8L0321, and CFRPG8K0051,61,71,81/Chang Gung Memorial 
      Hospital/
PT  - Journal Article
DEP - 20220504
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC9139573
OTO - NOTNLM
OT  - allergy
OT  - body height
OT  - body weight
OT  - childhood
OT  - total and specific IgE
COIS- The authors declare that they have no conflicts of interest in relation to this 
      study.
EDAT- 2022/05/29 06:00
MHDA- 2022/05/29 06:01
PMCR- 2022/05/04
CRDT- 2022/05/28 01:13
PHST- 2022/03/30 00:00 [received]
PHST- 2022/04/28 00:00 [revised]
PHST- 2022/04/30 00:00 [accepted]
PHST- 2022/05/28 01:13 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/05/29 06:01 [medline]
PHST- 2022/05/04 00:00 [pmc-release]
AID - children9050661 [pii]
AID - children-09-00661 [pii]
AID - 10.3390/children9050661 [doi]
PST - epublish
SO  - Children (Basel). 2022 May 4;9(5):661. doi: 10.3390/children9050661.