PMID- 35626879 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 9 IP - 5 DP - 2022 May 10 TI - Oxidative and Inflammatory Markers Are Higher in Full-Term Newborns Suffering Funisitis, and Higher Oxidative Markers Are Associated with Admission. LID - 10.3390/children9050702 [doi] LID - 702 AB - The aim of this study was to assess whether oxidative and inflammatory mediators in the cord blood of newborns with funisitis and chorioamnionitis can serve as indicators of their inflammatory status, and whether there is a positive association between higher mediator levels and an increased risk of admission to the neonatal intensive care unit (NICU). This study was conducted prospectively in a neonatology department of a university hospital. In total, 52 full-term newborns were evaluated, including 17 funisitis cases, 13 chorioamnionitis cases, and 22 control newborns without funisitis or chorioamnionitis. Cord blood samples were measured for oxidative stress and inflammatory status markers. The oxidative stress markers included the total nitric oxide (NO), total hydroperoxide (TH), biological antioxidant potential (BAP), and TH/BAP ratio, comprising the oxidative stress index (OSI). Inflammatory markers included interleukin (IL)-1b, IL-6, IL-8, IL-10, tumor necrosis factor alpha (TNFalpha), interferon gamma (IFNgamma), and complement component C5a. TH, OSI, IL-1b, IL-6, and IL-8 concentrations were higher in the funisitis group than in the chorioamnionitis and control groups. C5a was higher in the funisitis and chorioamnionitis groups than in the control group. Among all enrolled newborns, 14 were admitted to the NICU. Multiple logistic regression analysis showed that elevated umbilical cord blood levels of OSI and TH were associated with a higher risk of admission to the NICU (OSI: R = 2.3, 95% CI 1.26-4.29, p = 0.007 and TH: R = 1.02, 95%CI = 1.004-1.040, p = 0.015). In conclusion, OSI and TH in cord blood from full-term newborns can provide an index of inflammatory status, and higher levels are associated with the risk of admission to the NICU and, therefore, could serve as an early indicator of inflammatory conditions in newborns. FAU - Kamei, Michi AU - Kamei M AD - Department of Pediatrics and Neonatology, Graduate School of Medical Science, Nagoya City University, Nagoya 467-8601, Japan. FAU - Hussein, Mohamed Hamed AU - Hussein MH AUID- ORCID: 0000-0003-3842-0468 AD - Department of Medical Research and Development, Kinjo Gakuin University, Nagoya 463-8521, Japan. AD - Division of Neonatology, Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan. FAU - Hattori, Ayako AU - Hattori A AD - Department of Pediatrics and Neonatology, Graduate School of Medical Science, Nagoya City University, Nagoya 467-8601, Japan. FAU - Saleh, Marwa AU - Saleh M AD - Division of Neonatology, Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan. FAU - Kakita, Hiroki AU - Kakita H AD - Department of Perinatal and Neonatal Medicine, Aichi Medical University, Nagakute 480-1195, Japan. FAU - Abdel-Hamid Daoud, Ghada AU - Abdel-Hamid Daoud G AD - Independent Researcher, AlMaadi, Cairo 11742, Egypt. FAU - Ishiguro, Akio AU - Ishiguro A AD - Division of Neonatology, Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan. FAU - Namba, Fumihiko AU - Namba F AUID- ORCID: 0000-0001-6137-4477 AD - Division of Neonatology, Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan. FAU - Yazaki, Makoto AU - Yazaki M AD - Department of Pediatrics, Hoshigaoka Maternity Hospital, Nagoya 464-0026, Japan. FAU - Goto, Haruo AU - Goto H AD - Department of Pediatrics, Nagoya City University West Medical Center, Nagoya 462-0033, Japan. FAU - Kato, Ineko AU - Kato I AD - Department of Medical Research and Development, Kinjo Gakuin University, Nagoya 463-8521, Japan. FAU - Sobajima, Hisanori AU - Sobajima H AD - Division of Neonatology, Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan. FAU - Kazuhiko, Kabe AU - Kazuhiko K AD - Division of Neonatology, Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan. FAU - Moriwaki, Koichi AU - Moriwaki K AUID- ORCID: 0000-0002-5848-7427 AD - Department of Pediatrics, Center of Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe 350-8550, Japan. FAU - Togari, Hajime AU - Togari H AD - Department of Medical Research and Development, Kinjo Gakuin University, Nagoya 463-8521, Japan. LA - eng PT - Journal Article DEP - 20220510 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC9139500 OTO - NOTNLM OT - cytokines OT - free radicals OT - inflammation OT - neonate COIS- The authors declare that they have no conflict of interest. EDAT- 2022/05/29 06:00 MHDA- 2022/05/29 06:01 PMCR- 2022/05/10 CRDT- 2022/05/28 01:13 PHST- 2022/03/18 00:00 [received] PHST- 2022/04/30 00:00 [revised] PHST- 2022/04/30 00:00 [accepted] PHST- 2022/05/28 01:13 [entrez] PHST- 2022/05/29 06:00 [pubmed] PHST- 2022/05/29 06:01 [medline] PHST- 2022/05/10 00:00 [pmc-release] AID - children9050702 [pii] AID - children-09-00702 [pii] AID - 10.3390/children9050702 [doi] PST - epublish SO - Children (Basel). 2022 May 10;9(5):702. doi: 10.3390/children9050702.