PMID- 35627690
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 10
DP  - 2022 May 18
TI  - A Bibliometric Analysis of the Literature on Irisin from 2012-2021.
LID - 10.3390/ijerph19106153 [doi]
LID - 6153
AB  - Irisin is a hormone-like molecule mainly released by skeletal muscles in response 
      to exercise, which is proposed to induce the 'browning' of white adipose tissue. 
      Since its identification, irisin was reported to be closely associated with many 
      metabolic diseases, including type 2 diabetes mellitus (T2DM), obesity, 
      cardiovascular disease (CVD), and metabolic bone diseases. In recent years, 
      irisin has attracted increasing research interest, and numerous studies have been 
      published in this field. Thus, it is essential to identify the current research 
      status of irisin and measure research hotspots and possible future trends. In 
      this study, by utilizing two visualization software named CiteSpace and 
      VOSviewer, we analyzed 1510 Web of Science publications on irisin published from 
      2012 to 2021. Our results show that the number of irisin-related articles 
      published annually has increased significantly. China participates in the most 
      studies, followed by the United States and Turkey. Firat University, Harvard 
      University, and Shandong University are three major institutions with larger 
      numbers of publications. The analysis of keywords co-occurrence indicates that 
      insulin resistance, inflammation, and circulating irisin levels in serum are the 
      research hotspots. Apoptosis, BDNF, and osteoporosis will likely become the focus 
      of future research related to irisin. Overall, this study may provide helpful 
      insights for researchers to understand the current research situation and 
      identify the potential frontiers of irisin.
FAU - Liu, Jiangshan
AU  - Liu J
AD  - College of Physical Education, Changzhou University, Changzhou 213164, China.
FAU - Qi, Bote
AU  - Qi B
AD  - Department of Sport and Exercise Science, College of Education, Zhejiang 
      University, Hangzhou 310058, China.
FAU - Gan, Lin
AU  - Gan L
AD  - College of Physical Education, Changzhou University, Changzhou 213164, China.
FAU - Shen, Yanli
AU  - Shen Y
AD  - Library of Shanghai University of Sport, Shanghai 200438, China.
FAU - Zou, Yu
AU  - Zou Y
AD  - Department of Sport and Exercise Science, College of Education, Zhejiang 
      University, Hangzhou 310058, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220518
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Fibronectins)
SB  - IM
MH  - Bibliometrics
MH  - *Diabetes Mellitus, Type 2
MH  - Fibronectins
MH  - Humans
MH  - *Insulin Resistance
MH  - Publications
MH  - United States
PMC - PMC9141152
OTO - NOTNLM
OT  - CiteSpace
OT  - VOSviewer
OT  - bibliometric
OT  - exercise
OT  - irisin
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/05/18
CRDT- 2022/05/28 01:18
PHST- 2022/04/05 00:00 [received]
PHST- 2022/05/08 00:00 [revised]
PHST- 2022/05/15 00:00 [accepted]
PHST- 2022/05/28 01:18 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/05/18 00:00 [pmc-release]
AID - ijerph19106153 [pii]
AID - ijerph-19-06153 [pii]
AID - 10.3390/ijerph19106153 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 May 18;19(10):6153. doi: 
      10.3390/ijerph19106153.