PMID- 35628525
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 10
DP  - 2022 May 20
TI  - Water-Soluble, Alanine-Modified Fullerene C(60) Promotes the Proliferation and 
      Neuronal Differentiation of Neural Stem Cells.
LID - 10.3390/ijms23105714 [doi]
LID - 5714
AB  - As carbon-based nanomaterials, water-soluble C(60) derivatives have potential 
      applications in various fields of biomedicine. In this study, a water-soluble 
      fullerene C(60) derivative bearing alanine residues (Ala-C(60)) was synthesized. 
      The effects of Ala-C(60) on neural stem cells (NSCs) as seed cells were explored. 
      Ala-C(60) can promote the proliferation of NSCs, induce NSCs to differentiate 
      into neurons, and inhibit the migration of NSCs. Most importantly, the Ala-C(60) 
      can significantly increase the cell viability of NSCs treated with hydrogen 
      peroxide (H(2)O(2)). The glutathioneperoxidase (GSH-Px) and superoxide dismutase 
      (SOD) activities and glutathione (GSH) content increased significantly in NSCs 
      treated even by 20 muM Ala-C(60). These findings strongly indicate that Ala-C(60) 
      has high potential to be applied as a scaffold with NSCs for regeneration in 
      nerve tissue engineering for diseases related to the nervous system.
FAU - Ren, Haiyuan
AU  - Ren H
AD  - Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of 
      Medicine, Shandong University, Jinan 250012, China.
FAU - Li, Jinrui
AU  - Li J
AD  - Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School 
      of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
FAU - Peng, Ai
AU  - Peng A
AD  - Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of 
      Medicine, Shandong University, Jinan 250012, China.
FAU - Liu, Ting
AU  - Liu T
AD  - Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of 
      Medicine, Shandong University, Jinan 250012, China.
FAU - Chen, Mengjun
AU  - Chen M
AD  - School of Qilu Transportation, Shandong University, Jinan 250002, China.
FAU - Li, Hongguang
AU  - Li H
AD  - Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School 
      of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
FAU - Wang, Xiaojing
AU  - Wang X
AD  - Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of 
      Medicine, Shandong University, Jinan 250012, China.
LA  - eng
GR  - 21875129/National Natural Science Foundation of China/
GR  - ZR2021MH205/Natural Science Foundation of Shandong Province/
PT  - Journal Article
DEP - 20220520
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Fullerenes)
RN  - 059QF0KO0R (Water)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Alanine/pharmacology
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - *Fullerenes/pharmacology
MH  - Hydrogen Peroxide/pharmacology
MH  - *Neural Stem Cells
MH  - Water/pharmacology
PMC - PMC9146176
OTO - NOTNLM
OT  - H2O2
OT  - NSCs
OT  - differentiation
OT  - fullerene C60 derivatives
OT  - proliferation
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/05/20
CRDT- 2022/05/28 01:23
PHST- 2022/04/26 00:00 [received]
PHST- 2022/05/14 00:00 [revised]
PHST- 2022/05/17 00:00 [accepted]
PHST- 2022/05/28 01:23 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/05/20 00:00 [pmc-release]
AID - ijms23105714 [pii]
AID - ijms-23-05714 [pii]
AID - 10.3390/ijms23105714 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 May 20;23(10):5714. doi: 10.3390/ijms23105714.