PMID- 35628567
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 10
DP  - 2022 May 20
TI  - Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced 
      Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation 
      of Vasodilation.
LID - 10.3390/ijms23105757 [doi]
LID - 5757
AB  - Advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE) are 
      implicated in inflammatory reactions and vascular complications in diabetes. 
      Signaling pathways downstream of RAGE are involved in NF-kappaB activation. In this 
      study, we examined whether ethanol extracts of Saururus chinensis (Lour.) Baill. 
      (SE) could affect RAGE signaling and vascular relaxation in streptozotocin 
      (STZ)-induced diabetic rats. Treatment with SE inhibited AGEs-modified bovine 
      serum albumin (AGEs-BSA)-elicited activation of NF-kappaB and could compete with 
      AGEs-BSA binding to RAGE in a dose-dependent manner. Tumor necrosis factor-alpha 
      (TNF-alpha) secretion induced by lipopolysaccharide (LPS)-a RAGE ligand-was also 
      reduced by SE treatment in wild-type Ager(+/+) mice as well as in cultured 
      peritoneal macrophages from Ager(+/+) mice but not in Ager(-/-) mice. SE 
      administration significantly ameliorated diabetes-related dysregulation of 
      acetylcholine-mediated vascular relaxation in STZ-induced diabetic rats. These 
      results suggest that SE would inhibit RAGE signaling and would be useful for the 
      improvement of vascular endothelial dysfunction in diabetes.
FAU - Hayashi, Kenjiro
AU  - Hayashi K
AD  - Food Development Labs, Functional Food Division, Nippon Shinyaku Co., Ltd., Kyoto 
      601-8550, Japan.
AD  - Department of Biochemistry and Molecular Vascular Biology, Kanazawa University 
      Graduate School of Medical Sciences, Kanazawa 920-8640, Japan.
FAU - Sato, Koichi
AU  - Sato K
AD  - Food Development Labs, Functional Food Division, Nippon Shinyaku Co., Ltd., Kyoto 
      601-8550, Japan.
FAU - Ochi, Seishi
AU  - Ochi S
AD  - Food Development Labs, Functional Food Division, Nippon Shinyaku Co., Ltd., Kyoto 
      601-8550, Japan.
FAU - Kawano, Shuhei
AU  - Kawano S
AD  - Food Development Labs, Functional Food Division, Nippon Shinyaku Co., Ltd., Kyoto 
      601-8550, Japan.
FAU - Munesue, Seiichi
AU  - Munesue S
AD  - Department of Biochemistry and Molecular Vascular Biology, Kanazawa University 
      Graduate School of Medical Sciences, Kanazawa 920-8640, Japan.
FAU - Harashima, Ai
AU  - Harashima A
AD  - Department of Biochemistry and Molecular Vascular Biology, Kanazawa University 
      Graduate School of Medical Sciences, Kanazawa 920-8640, Japan.
FAU - Oshima, Yu
AU  - Oshima Y
AD  - Department of Biochemistry and Molecular Vascular Biology, Kanazawa University 
      Graduate School of Medical Sciences, Kanazawa 920-8640, Japan.
FAU - Kimura, Kumi
AU  - Kimura K
AD  - Department of Biochemistry and Molecular Vascular Biology, Kanazawa University 
      Graduate School of Medical Sciences, Kanazawa 920-8640, Japan.
FAU - Kyoi, Takashi
AU  - Kyoi T
AD  - Food Development Labs, Functional Food Division, Nippon Shinyaku Co., Ltd., Kyoto 
      601-8550, Japan.
FAU - Yamamoto, Yasuhiko
AU  - Yamamoto Y
AUID- ORCID: 0000-0003-1326-4649
AD  - Department of Biochemistry and Molecular Vascular Biology, Kanazawa University 
      Graduate School of Medical Sciences, Kanazawa 920-8640, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220520
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Carrier Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Animals
MH  - Carrier Proteins
MH  - *Diabetes Mellitus, Experimental/drug therapy/metabolism
MH  - Inflammation/drug therapy
MH  - Mice
MH  - NF-kappa B/metabolism
MH  - Plant Extracts/pharmacology
MH  - Rats
MH  - Receptor for Advanced Glycation End Products/genetics/metabolism
MH  - Receptors, Immunologic/genetics/metabolism
MH  - *Saururaceae/metabolism
MH  - Vasodilation
PMC - PMC9147798
OTO - NOTNLM
OT  - Saururus chinensis (Lour.) Baill
OT  - receptor for advanced glycation end-products (RAGE)
OT  - vascular relaxation
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/05/20
CRDT- 2022/05/28 01:23
PHST- 2021/12/17 00:00 [received]
PHST- 2022/05/19 00:00 [revised]
PHST- 2022/05/19 00:00 [accepted]
PHST- 2022/05/28 01:23 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/05/20 00:00 [pmc-release]
AID - ijms23105757 [pii]
AID - ijms-23-05757 [pii]
AID - 10.3390/ijms23105757 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 May 20;23(10):5757. doi: 10.3390/ijms23105757.