PMID- 35628757
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2309-608X (Electronic)
IS  - 2309-608X (Linking)
VI  - 8
IP  - 5
DP  - 2022 May 12
TI  - Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of 
      Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused 
      by Paracoccidioides sp.
LID - 10.3390/jof8050502 [doi]
LID - 502
AB  - Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Brazil. 
      The disease is caused by dimorphic fungi nested within the Paracoccidioides 
      genus. We described 106 PCM cases (47.1 cases/year) at the Tropical Diseases 
      Public Hospital of Tocantins State. PCM was prevalent in males and rural workers 
      over 50 years; the chronic pulmonary form predominated in 67% of cases. The 
      male-to-female ratio was 2.65:1, with more women affected than other endemic 
      regions of Brazil. Urban or indoor activities were reported in women and are 
      ascribed to disease urbanization. qPCR-based assays confirmed the identification 
      of Paracoccidioides DNA in 37 biological specimens. Paracoccidioides sp. DNA was 
      found in 53% of the environmental samples, suggesting autochthonous infections. 
      Therefore, the Tocantins-Araguaia basin must be considered a novel hyperendemic 
      area of PCM in Brazil, reinforcing the importance of including PCM as a 
      notifiable disease, requiring specific diagnosis and health measures.
FAU - Krakhecke-Teixeira, Alessandra G
AU  - Krakhecke-Teixeira AG
AD  - Tocantins Department of Public Health, Palmas 77015-007, TO, Brazil.
AD  - Institute of Tropical Medicine, University of Sao Paulo, Sao Paulo 05403-000, SP, 
      Brazil.
FAU - Yamauchi, Danielle H
AU  - Yamauchi DH
AUID- ORCID: 0000-0003-2687-5836
AD  - Department of Chemical and Biological Sciences, Sao Paulo State University "Julio 
      de Mesquita Filho", Botucatu 18618-687, SP, Brazil.
FAU - Rossi, Alexsandra
AU  - Rossi A
AD  - Tocantins Department of Public Health, Palmas 77015-007, TO, Brazil.
FAU - de Sousa, Herdson R
AU  - de Sousa HR
AD  - Nucleo de Medicina Tropical, Faculty of Medicine, University of Brasilia, Campus 
      Universitario Darcy Ribeiro, Brasilia 70910-900, DF, Brazil.
FAU - Garces, Hans G
AU  - Garces HG
AUID- ORCID: 0000-0002-6100-3534
AD  - Department of Chemical and Biological Sciences, Sao Paulo State University "Julio 
      de Mesquita Filho", Botucatu 18618-687, SP, Brazil.
FAU - Junior, Joaquim L
AU  - Junior JL
AD  - Oswaldo Cruz Foundation (Fiocruz), Brasilia 70904-130, DF, Brazil.
FAU - Junior, Antonio O S
AU  - Junior AOS
AD  - Medical School, Federal University of Tocantins, Araguaina 77402-970, TO, Brazil.
FAU - Felipe, Maria Sueli S
AU  - Felipe MSS
AD  - Graduate Program in Genomic Sciences and Biotechnology, Catholic University of 
      Brasilia, Brasilia 70790-160, DF, Brazil.
FAU - Bagagli, Eduardo
AU  - Bagagli E
AD  - Department of Chemical and Biological Sciences, Sao Paulo State University "Julio 
      de Mesquita Filho", Botucatu 18618-687, SP, Brazil.
FAU - de Andrade, Heitor F Jr
AU  - de Andrade HF Jr
AD  - Institute of Tropical Medicine, University of Sao Paulo, Sao Paulo 05403-000, SP, 
      Brazil.
FAU - Teixeira, Marcus de M
AU  - Teixeira MM
AUID- ORCID: 0000-0003-1763-3464
AD  - Nucleo de Medicina Tropical, Faculty of Medicine, University of Brasilia, Campus 
      Universitario Darcy Ribeiro, Brasilia 70910-900, DF, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20220512
PL  - Switzerland
TA  - J Fungi (Basel)
JT  - Journal of fungi (Basel, Switzerland)
JID - 101671827
PMC - PMC9145993
OTO - NOTNLM
OT  - Northern Brazil
OT  - Paracoccidioides brasiliensis
OT  - Paracoccidioides lutzii
OT  - Tocantins-Araguaia basin
OT  - paracoccidioidomycosis
COIS- The authors report no conflict of interest of any kind in this work. The authors 
      alone are responsible for the content and writing of this manuscript.
EDAT- 2022/05/29 06:00
MHDA- 2022/05/29 06:01
PMCR- 2022/05/12
CRDT- 2022/05/28 01:24
PHST- 2022/03/29 00:00 [received]
PHST- 2022/04/18 00:00 [revised]
PHST- 2022/04/20 00:00 [accepted]
PHST- 2022/05/28 01:24 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/05/29 06:01 [medline]
PHST- 2022/05/12 00:00 [pmc-release]
AID - jof8050502 [pii]
AID - jof-08-00502 [pii]
AID - 10.3390/jof8050502 [doi]
PST - epublish
SO  - J Fungi (Basel). 2022 May 12;8(5):502. doi: 10.3390/jof8050502.