PMID- 35629062
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 10
DP  - 2022 May 23
TI  - Dapagliflozin Impact on the Exercise Capacity of Non-Diabetic Heart Failure with 
      Reduced Ejection Fraction Patients.
LID - 10.3390/jcm11102935 [doi]
LID - 2935
AB  - Background: Dapagliflozin has been shown to reduce morbidity and mortality in 
      Heart Failure with reduced Ejection Fraction (HFrEF), but its impact on exercise 
      capacity of non-diabetic HF outpatients is unknown. Methods: Adult non-diabetic 
      HF patients with a left ventricular ejection fraction (LVEF) <50% were randomized 
      1:1 to receive dapagliflozin 10 mg or to continue with HF medication. Patients 
      underwent an initial evaluation which was repeated after 6 months. The variation 
      of several clinical parameters was compared, with the primary endpoint being the 
      6 month peak oxygen uptake (pVO2) variation. Results: A total of 40 patients were 
      included (mean age 61 +/- 13 years, 82.5% male, mean LVEF 34 +/- 5%), half being 
      randomized to dapagliflozin, with no significant baseline differences between 
      groups. The reported drug compliance was 100%, with no major safety events. No 
      statistically significant difference in HF events was found (p = 0.609). There 
      was a 24% reduction in the number of patients in New York Heart Association 
      (NYHA) class III in the treatment group as opposed to a 15.8% increase in the 
      control group (p = 0.004). Patients under dapagliflozin had a greater improvement 
      in pVO2 (3.1 vs. 0.1 mL/kg/min, p = 0.030) and a greater reduction in NT-proBNP 
      levels (-217.6 vs. 650.3 pg/mL, p = 0.007). Conclusion: Dapagliflozin was 
      associated with a significant improvement in cardiopulmonary fitness at 6 months 
      follow-up in non-diabetic HFrEF patients.
FAU - Reis, Joao
AU  - Reis J
AD  - Department of Cardiology, Hospital de Santa Marta, Centro Hospitalar e 
      Universitario de Lisboa Central, Rua de Santa Marta 50, 1169-024 Lisbon, 
      Portugal.
FAU - Teixeira, Ana Rita
AU  - Teixeira AR
AD  - Department of Cardiology, Hospital de Santa Marta, Centro Hospitalar e 
      Universitario de Lisboa Central, Rua de Santa Marta 50, 1169-024 Lisbon, 
      Portugal.
FAU - Goncalves, Antonio Valentim
AU  - Goncalves AV
AUID- ORCID: 0000-0003-4614-4977
AD  - Department of Cardiology, Hospital de Santa Marta, Centro Hospitalar e 
      Universitario de Lisboa Central, Rua de Santa Marta 50, 1169-024 Lisbon, 
      Portugal.
FAU - Moreira, Rita Ilhao
AU  - Moreira RI
AD  - Department of Cardiology, Hospital de Santa Marta, Centro Hospitalar e 
      Universitario de Lisboa Central, Rua de Santa Marta 50, 1169-024 Lisbon, 
      Portugal.
FAU - Silva, Tiago Pereira
AU  - Silva TP
AUID- ORCID: 0000-0003-0467-2608
AD  - Department of Cardiology, Hospital de Santa Marta, Centro Hospitalar e 
      Universitario de Lisboa Central, Rua de Santa Marta 50, 1169-024 Lisbon, 
      Portugal.
FAU - Timoteo, Ana Teresa
AU  - Timoteo AT
AD  - Department of Cardiology, Hospital de Santa Marta, Centro Hospitalar e 
      Universitario de Lisboa Central, Rua de Santa Marta 50, 1169-024 Lisbon, 
      Portugal.
FAU - Ferreira, Rui Cruz
AU  - Ferreira RC
AD  - Department of Cardiology, Hospital de Santa Marta, Centro Hospitalar e 
      Universitario de Lisboa Central, Rua de Santa Marta 50, 1169-024 Lisbon, 
      Portugal.
LA  - eng
PT  - Journal Article
DEP - 20220523
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9144118
OTO - NOTNLM
OT  - Heart Failure with reduced Ejection Fraction
OT  - cardiopulmonary exercise test
OT  - heart failure
OT  - peak oxygen uptake
OT  - sodium-glucose co-transporter 2 inhibitors
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/05/29 06:01
PMCR- 2022/05/23
CRDT- 2022/05/28 01:26
PHST- 2022/03/26 00:00 [received]
PHST- 2022/05/09 00:00 [revised]
PHST- 2022/05/19 00:00 [accepted]
PHST- 2022/05/28 01:26 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/05/29 06:01 [medline]
PHST- 2022/05/23 00:00 [pmc-release]
AID - jcm11102935 [pii]
AID - jcm-11-02935 [pii]
AID - 10.3390/jcm11102935 [doi]
PST - epublish
SO  - J Clin Med. 2022 May 23;11(10):2935. doi: 10.3390/jcm11102935.