PMID- 35629188
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 12
IP  - 5
DP  - 2022 May 9
TI  - Interleaved Optical Coherence Tomography: Clinical and Laboratory Biomarkers in 
      Patients with Diabetic Macular Edema.
LID - 10.3390/jpm12050765 [doi]
LID - 765
AB  - (1) Background: The global burden of diabetes mellitus (DM) has been estimated to 
      reach 600 million patients worldwide by 2040. Approximately 200 million people 
      will develop diabetic retinopathy within this time frame. Diabetic macular edema 
      (DME) is a severe, vision-threatening complication that can develop at any stage 
      of diabetic retinopathy, and it represents the main cause of vision loss in 
      patients with DM. Its harmful consequences on visual function could be prevented 
      with timely recognition and treatment. (2) Methods: This study assessed the 
      clinical (demographic characteristics, diabetic evolution, and systemic vascular 
      complications); laboratory (glycated hemoglobin, metabolic parameters, capillary 
      oxygen saturation, and renal function); ophthalmologic exam; and spectral-domain 
      optical coherence tomography (SD-OCT) (macular volume, central macular thickness, 
      maximal central thickness, minimal central thickness, foveal thickness, superior 
      inner, inferior inner, nasal inner, temporal inner, inferior outer, superior 
      outer, nasal outer, and temporal outer thicknesses, disruption of the ellipsoid 
      zone, and disruption of the inner retinal layers (DRIL) parameters in three 
      groups of individuals: healthy controls (HC), patients with DME and type 1 DM 
      (T1DM-group A), and patients with DME and type 2 DM (T2DM-group B) to identify 
      novel correlations between them that would open a path to new pathogenetic 
      hypotheses and, implicitly, to the identification of new therapeutic methods, as 
      part of a tailored treatment within the concept of precision medicine. (3) 
      Results: The duration of DM was significantly longer in group A as compared with 
      group B, as were the prevalence of smoking and systemic vascular complications. 
      Capillary oxygen saturation and estimated glomerular filtration rates were 
      significantly lower, and serum creatinine levels were significantly higher in 
      group A as compared to group B. Regarding the OCT findings, DME had a 
      predominantly eccentric pattern, and the right eye was more severely affected in 
      both groups of patients. Significantly higher values were obtained in group B as 
      compared to group A for the following OCT biomarkers: macular volume, central 
      macular thickness, maximal central thickness, minimal central thickness, foveal 
      thickness, superior inner, inferior inner, nasal inner, inferior outer and nasal 
      outer thickness. The disruption of the ellipsoid zone was significantly more 
      prevalent within group A, whereas the overall disruption of the retinal inner 
      layers (DRIL) was identified significantly more frequently in group B. (4) 
      Conclusions: Whereas systemic and laboratory biomarkers were more severely 
      affected in patients with DME and T1DM, the OCT quantitative biomarkers revealed 
      significantly higher values in patients with DME and T2DM.
FAU - Suciu, Corina-Iuliana
AU  - Suciu CI
AUID- ORCID: 0000-0001-9190-1952
AD  - Department of Ophthalmology, "Iuliu Hatieganu" University of Medicine and 
      Pharmacy, 400012 Cluj-Napoca, Romania.
FAU - Suciu, Vlad-Ioan
AU  - Suciu VI
AUID- ORCID: 0000-0003-0885-8901
AD  - Department of Neuroscience, "Iuliu Hatieganu" University of Medicine and 
      Pharmacy, 400012 Cluj-Napoca, Romania.
FAU - Cutas, Ancuta
AU  - Cutas A
AD  - Department of Medical Statistics, "Iuliu Hatieganu" University of Medicine and 
      Pharmacy, 400012 Cluj-Napoca, Romania.
FAU - Nicoara, Simona Delia
AU  - Nicoara SD
AUID- ORCID: 0000-0002-7886-2044
AD  - Department of Ophthalmology, "Iuliu Hatieganu" University of Medicine and 
      Pharmacy, 400012 Cluj-Napoca, Romania.
AD  - Department of Ophthalmology, Emergency County Hospital, 400006 Cluj-Napoca, 
      Romania.
LA  - eng
PT  - Journal Article
DEP - 20220509
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC9147367
OTO - NOTNLM
OT  - OCT
OT  - biomarker
OT  - diabetes mellitus
OT  - diabetic macular edema
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/05/29 06:01
PMCR- 2022/05/09
CRDT- 2022/05/28 01:26
PHST- 2022/04/14 00:00 [received]
PHST- 2022/05/03 00:00 [revised]
PHST- 2022/05/06 00:00 [accepted]
PHST- 2022/05/28 01:26 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/05/29 06:01 [medline]
PHST- 2022/05/09 00:00 [pmc-release]
AID - jpm12050765 [pii]
AID - jpm-12-00765 [pii]
AID - 10.3390/jpm12050765 [doi]
PST - epublish
SO  - J Pers Med. 2022 May 9;12(5):765. doi: 10.3390/jpm12050765.