PMID- 35629246
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 12
IP  - 5
DP  - 2022 May 19
TI  - Exposure to Proton Pump Inhibitors and the Risk of Incident Asthma in Patients 
      with Coronary Artery Diseases: A Population-Based Cohort Study.
LID - 10.3390/jpm12050824 [doi]
LID - 824
AB  - We aimed to determine the association between proton pump inhibitor (PPI) use and 
      incident asthma in patients with coronary artery disease (CAD). This nationwide 
      cohort study collected claims data from the Taiwanese Bureau of National Health 
      Insurance from 2004 to 2013. The primary outcome, i.e., the risk of incident 
      asthma, was assessed by estimating hazard ratios (HRs) and 95% confidence 
      intervals (CIs). The adjusted HR of asthma development was estimated using the 
      Cox regression model. Sensitivity and subgroup analyses were also conducted. A 
      total of 8894 PPI users and 12,684 H2-receptor antagonist (H2RA) users were 
      included in patients with CAD. Compared with H2RA use, an increased risk of 
      incident asthma was found between PPI use and the risk of incident asthma in 
      patients with CAD after adjusting for sex, age, urbanization, and low income (HR: 
      1.41; 95% CI: 1.04-1.89). The sensitivity analysis results were consistent with 
      the main analysis results. However, the subgroup analysis revealed no association 
      of incident asthma in patients with diabetes mellitus, hyperlipidemia, stroke, 
      allergic rhinitis, pneumonia, cancer, or depression in the PPI group compared 
      with those in the H2RA group. In conclusion, PPI use increased the risk of asthma 
      development in patients with CAD.
FAU - Lin, Tsung-Kun
AU  - Lin TK
AUID- ORCID: 0000-0001-9421-7371
AD  - Department of Pharmacy, Taoyuan Armed Forces General Hospital, Taoyuan 32551, 
      Taiwan.
AD  - School of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan.
FAU - Tsai, Chin-Feng
AU  - Tsai CF
AUID- ORCID: 0000-0003-4475-9708
AD  - Division of Cardiology, Department of Internal Medicine, Chung Shan Medical 
      University Hospital, Taichung 40201, Taiwan.
AD  - School of Medicine and Institute of Medicine, Chung Shan Medical University, 
      Taichung 40201, Taiwan.
FAU - Huang, Jing-Yang
AU  - Huang JY
AUID- ORCID: 0000-0002-0794-9388
AD  - School of Medicine and Institute of Medicine, Chung Shan Medical University, 
      Taichung 40201, Taiwan.
AD  - Department of Medical Research, Chung Shan Medical University Hospital, Taichung 
      40201, Taiwan.
FAU - Pan, Lung-Fa
AU  - Pan LF
AD  - Graduate Institute of Radiological Science, Central Taiwan University of Science 
      and Technology, Taichung 40653, Taiwan.
AD  - Department of Cardiology, Taichung Armed Forces General Hospital, Taichung 41168, 
      Taiwan.
FAU - Jong, Gwo-Ping
AU  - Jong GP
AD  - Division of Cardiology, Department of Internal Medicine, Chung Shan Medical 
      University Hospital, Taichung 40201, Taiwan.
AD  - School of Medicine and Institute of Medicine, Chung Shan Medical University, 
      Taichung 40201, Taiwan.
LA  - eng
GR  - TYAFGH-D-109041/Taoyuan Armed Forces General Hospital/
PT  - Journal Article
DEP - 20220519
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC9146427
OTO - NOTNLM
OT  - asthma
OT  - coronary artery disease
OT  - peptic ulcer disease
OT  - proton pump inhibitors
COIS- The authors have declared that no competing interest exist.
EDAT- 2022/05/29 06:00
MHDA- 2022/05/29 06:01
PMCR- 2022/05/19
CRDT- 2022/05/28 01:26
PHST- 2022/04/24 00:00 [received]
PHST- 2022/05/12 00:00 [revised]
PHST- 2022/05/17 00:00 [accepted]
PHST- 2022/05/28 01:26 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/05/29 06:01 [medline]
PHST- 2022/05/19 00:00 [pmc-release]
AID - jpm12050824 [pii]
AID - jpm-12-00824 [pii]
AID - 10.3390/jpm12050824 [doi]
PST - epublish
SO  - J Pers Med. 2022 May 19;12(5):824. doi: 10.3390/jpm12050824.