PMID- 35629998
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 58
IP  - 5
DP  - 2022 Apr 23
TI  - Primary Fallopian Tube Carcinoma Presenting with a Massive Inguinal Tumor: A Case 
      Report and Literature Review.
LID - 10.3390/medicina58050581 [doi]
LID - 581
AB  - Primary fallopian tube carcinoma (PFTC) has characteristics similar to those of 
      ovarian carcinoma. The typical course of PFTC metastasis includes peritoneal 
      dissemination and pelvic and paraaortic lymph node metastasis, while inguinal 
      lymph node metastasis is rare. Moreover, the initial presentation of PFTC with an 
      inguinal tumor is extremely rare. A 77-year-old postmenopausal woman presented 
      with a massive 12-cm inguinal subcutaneous tumor. After tumor resection, 
      histopathological and immunohistochemical analysis showed that the tumor was a 
      high-grade serous carcinoma of gynecological origin. Subsequent surgery for total 
      hysterectomy with bilateral salpingo-oophorectomy revealed that the tumor 
      developed in the fallopian tube. She received adjuvant chemotherapy with 
      carboplatin and paclitaxel, followed by maintenance therapy with niraparib. There 
      has been no recurrence or metastasis 9 months after the second surgery. We 
      reviewed the literature for cases of PFTC and ovarian carcinoma that initially 
      presented with an inguinal tumor. In compliance with the Preferred Reporting 
      Items for Systematic Reviews guidelines, a systematic literature search was 
      performed through 31 January 2022 using the PubMed and Google scholar databases 
      and identified 14 cases. In half of them, it was difficult to identify the 
      primary site using preoperative imaging modalities. Disease recurrence occurred 
      in two cases; thus, the prognosis of this type of PFTC appears to be good.
FAU - Maeda, Michihide
AU  - Maeda M
AD  - Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, 
      Japan.
FAU - Hisa, Tsuyoshi
AU  - Hisa T
AD  - Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, 
      Japan.
FAU - Matsuzaki, Shinya
AU  - Matsuzaki S
AD  - Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, 
      Japan.
FAU - Ohe, Shuichi
AU  - Ohe S
AD  - Department of Dermatologic Oncology, Osaka International Cancer Institute, Osaka 
      541-8567, Japan.
FAU - Nagata, Shigenori
AU  - Nagata S
AD  - Department of Clinical Pathology, Osaka International Cancer Institute, Osaka 
      541-8567, Japan.
FAU - Lee, Misooja
AU  - Lee M
AD  - Department of Forensic Medicine, School of Medicine, Kindai University, Osaka 
      589-8511, Japan.
FAU - Mabuchi, Seiji
AU  - Mabuchi S
AD  - Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, 
      Japan.
FAU - Kamiura, Shoji
AU  - Kamiura S
AD  - Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, 
      Japan.
LA  - eng
PT  - Case Reports
PT  - Review
DEP - 20220423
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Aged
MH  - *Carcinoma
MH  - *Fallopian Tube Neoplasms/complications/pathology/surgery
MH  - Fallopian Tubes
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Neoplasm Recurrence, Local
MH  - *Ovarian Neoplasms/complications/surgery
PMC - PMC9147285
OTO - NOTNLM
OT  - inguinal lymph node metastasis
OT  - inguinal tumor
OT  - primary fallopian tube carcinoma
OT  - serous carcinoma
COIS- Research funding, MSD (Shinya Matsuzaki); none for others. The funder had no role 
      in the design and conduct of the study; collection, management, analysis, and 
      interpretation of the data; preparation, review, or approval of the manuscript; 
      and decision to submit the manuscript for publication.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/04/23
CRDT- 2022/05/28 01:30
PHST- 2022/03/18 00:00 [received]
PHST- 2022/04/19 00:00 [revised]
PHST- 2022/04/21 00:00 [accepted]
PHST- 2022/05/28 01:30 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/04/23 00:00 [pmc-release]
AID - medicina58050581 [pii]
AID - medicina-58-00581 [pii]
AID - 10.3390/medicina58050581 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2022 Apr 23;58(5):581. doi: 10.3390/medicina58050581.