PMID- 35630041
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 58
IP  - 5
DP  - 2022 Apr 29
TI  - Plasma Concentrations of Cytokines in Patients with Combined Hyperlipidemia and 
      Atherosclerotic Plaque before Treatment Initiation-A Pilot Study.
LID - 10.3390/medicina58050624 [doi]
LID - 624
AB  - Background and Objectives: The formation and destabilization of atherosclerotic 
      plaques is a complex process involving several proteins and cytokines. 
      Interleukin 6 (IL-6), interleukin 18 (IL-18), and tumor necrosis factor (TNF-alpha) 
      are examples of such cytokines. The goal of our research is to compare the 
      concentrations of the above-mentioned indicators in the plasma of patients with 
      verified high-risk atherosclerotic plaque to the plasma levels of healthy people 
      before lipid lowering therapy. Materials and Methods: Patients with dyslipidemia 
      who had the presence of unstable atherosclerotic plaque verified by 
      ultrasonography were included in the study. The concentrations of IL-6, IL-18 and 
      TNF-alpha in the plasma of these people were determined and compared with the 
      concentrations of these cytokines in the plasma of the control group. Results: 
      Levels of lipid panel, IL-6 and IL-18 were significantly lower in the group of 
      healthy people than in the study group. Conclusions: The concentrations of IL-6 
      and IL-18 in the plasma of patients with ruptured plaque are higher than in the 
      plasma of healthy people, suggesting that these cytokines as a panel might be 
      used as new indicators of the presence of unstable atherosclerotic plaque.
FAU - Basiak, Marcin
AU  - Basiak M
AUID- ORCID: 0000-0003-0674-5612
AD  - Department of Internal Medicine and Clinical Pharmacology, Medical University of 
      Silesia, Medykow 18, 40-752 Katowice, Poland.
FAU - Kosowski, Michal
AU  - Kosowski M
AUID- ORCID: 0000-0003-2597-463X
AD  - Department of Internal Medicine and Clinical Pharmacology, Medical University of 
      Silesia, Medykow 18, 40-752 Katowice, Poland.
FAU - Hachula, Marcin
AU  - Hachula M
AD  - Department of Internal Medicine and Clinical Pharmacology, Medical University of 
      Silesia, Medykow 18, 40-752 Katowice, Poland.
FAU - Okopien, Boguslaw
AU  - Okopien B
AUID- ORCID: 0000-0001-7228-2906
AD  - Department of Internal Medicine and Clinical Pharmacology, Medical University of 
      Silesia, Medykow 18, 40-752 Katowice, Poland.
LA  - eng
GR  - PCN-1-185/N/9/O/Medical University of Silesia/
PT  - Journal Article
DEP - 20220429
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipids)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Cytokines
MH  - Humans
MH  - *Hyperlipidemias
MH  - Interleukin-18
MH  - Interleukin-6
MH  - Lipids
MH  - Pilot Projects
MH  - *Plaque, Atherosclerotic/complications
MH  - Tumor Necrosis Factor-alpha/metabolism
PMC - PMC9143983
OTO - NOTNLM
OT  - atherosclerosis
OT  - hyperlipidemia
OT  - interleukin 18
OT  - interleukin 6
OT  - rupture plaque
OT  - tumor necrosis factor alfa
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/04/29
CRDT- 2022/05/28 01:31
PHST- 2022/03/21 00:00 [received]
PHST- 2022/04/27 00:00 [revised]
PHST- 2022/04/28 00:00 [accepted]
PHST- 2022/05/28 01:31 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/04/29 00:00 [pmc-release]
AID - medicina58050624 [pii]
AID - medicina-58-00624 [pii]
AID - 10.3390/medicina58050624 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2022 Apr 29;58(5):624. doi: 10.3390/medicina58050624.