PMID- 35631171
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 10
DP  - 2022 May 12
TI  - Metabolic Effects of an Oral Glucose Tolerance Test Compared to the Mixed Meal 
      Tolerance Tests: A Narrative Review.
LID - 10.3390/nu14102032 [doi]
LID - 2032
AB  - The oral glucose tolerance test (OGTT) is recommended for assessing abnormalities 
      in glucose homeostasis. Recognised as the gold standard test for diagnosing 
      diabetes, the OGTT provides useful information about glucose tolerance. However, 
      it does not replicate the process of absorption and digestion of complex foods, 
      such as that which occurs with a mixed meal tolerance test (MMTT), an alternative 
      that is still not well explored in the diagnosis of metabolic alterations. The 
      MMTT could be an asset in detecting glucose homeostasis disorders, including 
      diabetes since it has more similarities to the common dietary pattern, allowing 
      early detection of subtle changes in metabolic homeostasis in response to 
      combined nutrients. This alternative has the advantage of being more tolerable 
      and pleasant to patients since it induces a more gradual increase in blood 
      glucose, thus reducing the risk of rebound hypoglycemia and other related 
      complications. The present article reviewed the clinical data available regarding 
      the possibility of screening or diagnosing altered glucose homeostasis, including 
      type 2 diabetes mellitus, with the MMTT.
FAU - Lages, Marlene
AU  - Lages M
AD  - ciTechCare-Center for Innovative Care and Health Technology, Polytechnic of 
      Leiria, 2410-541 Leiria, Portugal.
AD  - Faculty of Nutrition and Food Science, University of Porto, 4150-180 Porto, 
      Portugal.
AD  - EPIUnit-Instituto de Saude Publica, Universidade do Porto, 4200-450 Porto, 
      Portugal.
FAU - Barros, Renata
AU  - Barros R
AUID- ORCID: 0000-0002-3043-1720
AD  - Faculty of Nutrition and Food Science, University of Porto, 4150-180 Porto, 
      Portugal.
AD  - EPIUnit-Instituto de Saude Publica, Universidade do Porto, 4200-450 Porto, 
      Portugal.
FAU - Moreira, Pedro
AU  - Moreira P
AUID- ORCID: 0000-0002-7035-7799
AD  - Faculty of Nutrition and Food Science, University of Porto, 4150-180 Porto, 
      Portugal.
AD  - EPIUnit-Instituto de Saude Publica, Universidade do Porto, 4200-450 Porto, 
      Portugal.
AD  - Laboratorio Para a Investigacao Integrativa e Translacional em Saude Populacional 
      (ITR), Portugal Centre in Physical Activity, Health and Leisure, University of 
      Porto, 4200-450 Porto, Portugal.
FAU - Guarino, Maria P
AU  - Guarino MP
AUID- ORCID: 0000-0001-6079-1105
AD  - Faculty of Nutrition and Food Science, University of Porto, 4150-180 Porto, 
      Portugal.
AD  - School of Health Sciences, Polytechnic of Leiria, 2411-901 Leiria, Portugal.
LA  - eng
GR  - UI/05704/2020/Fundacao para a Ciencia e Tecnologia/
GR  - 2021.07673.BD/Fundacao para a Ciencia e Tecnologia/
PT  - Journal Article
PT  - Review
DEP - 20220512
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - *Diabetes Mellitus, Type 2/diagnosis
MH  - Glucose Tolerance Test
MH  - Humans
MH  - *Hypoglycemia
MH  - Meals
PMC - PMC9147413
OTO - NOTNLM
OT  - diabetes
OT  - diagnosis
OT  - fasting plasma glucose
OT  - impaired fasting glycemia
OT  - impaired glucose tolerance
OT  - insulin resistance
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/05/12
CRDT- 2022/05/28 01:37
PHST- 2022/04/04 00:00 [received]
PHST- 2022/05/04 00:00 [revised]
PHST- 2022/05/08 00:00 [accepted]
PHST- 2022/05/28 01:37 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/05/12 00:00 [pmc-release]
AID - nu14102032 [pii]
AID - nutrients-14-02032 [pii]
AID - 10.3390/nu14102032 [doi]
PST - epublish
SO  - Nutrients. 2022 May 12;14(10):2032. doi: 10.3390/nu14102032.