PMID- 35631186
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 10
DP  - 2022 May 13
TI  - Vitamin B12 Deficiency in Patients with Diabetes on Metformin: Arab Countries.
LID - 10.3390/nu14102046 [doi]
LID - 2046
AB  - BACKGROUND: Diabetes is a global pandemic, especially in Arab countries. AIM: The 
      goal of this study was to review the published studies that were conducted to 
      determine the relationship between metformin treatment for type 2 diabetes 
      mellitus (T2DM) and vitamin B12 deficiency and to identify possible complications 
      in this relationship. METHODS: I searched for all relevant studies published in 
      English before 2020 on the PubMed and Web of Knowledge databases using the 
      following terms: "metformin", "vitamin B12", "neuropathy", "diabetes mellitus", 
      and Middle Eastern countries. RESULTS: Eleven studies were included in this 
      review which indicated an association between taking metformin and B12 deficiency 
      in patients with T2DM in Arab countries. This B12 deficiency was found to be 
      negatively associated with the dose and duration of metformin therapy. The 
      physician's knowledge of current ADA recommendations regarding supplementation 
      with and screening of the B12 level for T2DM patients on metformin was also found 
      to have an effect. CONCLUSION: Metformin therapy is associated with B12 
      deficiency among people with T2DM in Arabic countries. Thus, diabetes must be 
      managed in compliance with current guidelines and recommendations, and B12 levels 
      must be routinely monitored, particularly in those who have been long-term takers 
      of metformin, to ensure the suitable management of diabetes and its 
      complications.
FAU - Alhaji, Jwaher Haji
AU  - Alhaji JH
AUID- ORCID: 0000-0001-7473-3037
AD  - Department of Health Sciences, College of Applied Studies and Community Service, 
      King Saud University, P.O. Box 145111, Riyadh ZIP 4545, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220513
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Hypoglycemic Agents)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Arabs
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy/epidemiology
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - *Metformin/adverse effects
MH  - *Vitamin B 12 Deficiency/diagnosis
PMC - PMC9144422
OTO - NOTNLM
OT  - Arab countries
OT  - T2DM
OT  - diabetes
OT  - metformin
OT  - vitamin B12
COIS- The author declares no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/05/13
CRDT- 2022/05/28 01:37
PHST- 2022/04/21 00:00 [received]
PHST- 2022/05/07 00:00 [revised]
PHST- 2022/05/11 00:00 [accepted]
PHST- 2022/05/28 01:37 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/05/13 00:00 [pmc-release]
AID - nu14102046 [pii]
AID - nutrients-14-02046 [pii]
AID - 10.3390/nu14102046 [doi]
PST - epublish
SO  - Nutrients. 2022 May 13;14(10):2046. doi: 10.3390/nu14102046.