PMID- 35631196
OWN - NLM
STAT- MEDLINE
DCOM- 20220531
LR  - 20220716
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 10
DP  - 2022 May 13
TI  - Dietary Copper and Selenium Intakes and the Risk of Type 2 Diabetes Mellitus: 
      Findings from the China Health and Nutrition Survey.
LID - 10.3390/nu14102055 [doi]
LID - 2055
AB  - The long-term associations between dietary copper (Cu) and selenium (Se) intakes 
      and type 2 diabetes mellitus (T2DM) risk are unclear. We aimed to examine the 
      prospective associations between dietary Cu and Se intakes and T2DM risk in 
      Chinese adults. A total of 14,711 adults from the China Health and Nutrition 
      Survey (1997-2015) were included. Nutrient intakes were assessed by 3 consecutive 
      24 h recalls and food-weighing methods. T2DM was identified by a validated 
      questionnaire and laboratory examination. Cox regression models were used for 
      statistical analysis. A total of 1040 T2DM cases were diagnosed during 147,142 
      person-years of follow-up. In fully adjusted models, dietary Cu or Se intake was 
      not associated with T2DM risk. Dietary Se intake significantly modified the 
      association between dietary Cu intake and T2DM risk, and dietary Cu intake was 
      positively associated with T2DM risk when Se intake was lower than the median 
      (p-interaction = 0.0292). There were no significant effect modifications on the 
      associations by age, sex, BMI, or region. Although dietary Cu or Se intake was 
      not independently associated with T2DM risk in Chinese adults free from 
      cardiometabolic diseases and cancer at the baseline, there was a significant 
      interaction between dietary Cu and Se intakes on T2DM risk.
FAU - Cui, Zhixin
AU  - Cui Z
AD  - School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 
      Sun Yat-sen University, Shenzhen 518107, China.
FAU - Zhou, Haiyan
AU  - Zhou H
AD  - School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 
      Sun Yat-sen University, Shenzhen 518107, China.
FAU - Liu, Ke
AU  - Liu K
AD  - School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 
      Sun Yat-sen University, Shenzhen 518107, China.
FAU - Wu, Man
AU  - Wu M
AD  - School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 
      Sun Yat-sen University, Shenzhen 518107, China.
FAU - Li, Shun
AU  - Li S
AD  - School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 
      Sun Yat-sen University, Shenzhen 518107, China.
FAU - Meng, Shuangli
AU  - Meng S
AD  - School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 
      Sun Yat-sen University, Shenzhen 518107, China.
FAU - Meng, Huicui
AU  - Meng H
AUID- ORCID: 0000-0002-6090-8622
AD  - School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 
      Sun Yat-sen University, Shenzhen 518107, China.
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou 
      510080, China.
AD  - Guangdong Province Engineering Laboratory for Nutrition Translation, Guangzhou 
      510080, China.
LA  - eng
GR  - R01 HD038700/HD/NICHD NIH HHS/United States
GR  - 81903301/the National Natural Science Foundation of China/
GR  - P30 DK056350/DK/NIDDK NIH HHS/United States
GR  - GXWD20201231165807008, 20200830143250001/Shenzhen Science and Technology Program/
GR  - R01 HD030880/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20220513
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 789U1901C5 (Copper)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Adult
MH  - China/epidemiology
MH  - Copper
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Humans
MH  - Nutrition Surveys
MH  - *Selenium
PMC - PMC9142999
OTO - NOTNLM
OT  - Chinese adults
OT  - dietary copper
OT  - dietary selenium
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/06/01 06:00
PMCR- 2022/05/13
CRDT- 2022/05/28 01:37
PHST- 2022/04/02 00:00 [received]
PHST- 2022/05/08 00:00 [revised]
PHST- 2022/05/10 00:00 [accepted]
PHST- 2022/05/28 01:37 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/01 06:00 [medline]
PHST- 2022/05/13 00:00 [pmc-release]
AID - nu14102055 [pii]
AID - nutrients-14-02055 [pii]
AID - 10.3390/nu14102055 [doi]
PST - epublish
SO  - Nutrients. 2022 May 13;14(10):2055. doi: 10.3390/nu14102055.