PMID- 35631690
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230916
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 14
IP  - 5
DP  - 2022 May 21
TI  - Impact of Magnesium on Oxytocin Receptor Function.
LID - 10.3390/pharmaceutics14051105 [doi]
LID - 1105
AB  - BACKGROUND AND PURPOSE: The intranasal administration of oxytocin (OT) reduces 
      migraine headaches through activation of the oxytocin receptor (OTR). Magnesium 
      ion (Mg(2+)) concentration is critical to the activation of the OTR, and a low 
      serum Mg(2+) concentration is predictive of a migraine headache. We, therefore, 
      examined the functional impact of Mg(2+) concentration on OT-OTR binding efficacy 
      using two complimentary bioassays. EXPERIMENTAL APPROACH: Current clamp 
      recordings of rat trigeminal ganglia (TG) neurons measured the impact of Mg(2+) 
      on an OT-induced reduction in excitability. In addition, we assessed the impact 
      of Mg(2+) on intranasal OT-induced craniofacial analgesia in rats. KEY RESULTS: 
      While OT alone dose-dependently hyperpolarized TG neurons, decreasing their 
      excitability, the addition of 1.75 mM Mg(2+) significantly enhanced this effect. 
      Similarly, while the intranasal application of OT produced dose-dependent 
      craniofacial analgesia, Mg(2+) significantly enhanced these effects. CONCLUSIONS 
      AND IMPLICATIONS: OT efficacy may be limited by low ambient Mg(2+) levels. The 
      addition of Mg(2+) to OT formulations may improve its efficacy in reducing 
      headache pain as well as for other OT-dependent processes.
FAU - Bharadwaj, Vimala N
AU  - Bharadwaj VN
AUID- ORCID: 0000-0002-6243-0861
AD  - Department of Anesthesiology, Perioperative and Pain Medicine, School of 
      Medicine, Stanford University, Palo Alto, CA 94304, USA.
FAU - Meyerowitz, Justin
AU  - Meyerowitz J
AD  - Department of Anesthesiology, Perioperative and Pain Medicine, School of 
      Medicine, Stanford University, Palo Alto, CA 94304, USA.
FAU - Zou, Bende
AU  - Zou B
AD  - AfaSci Inc., Burlingame, CA 94010, USA.
FAU - Klukinov, Michael
AU  - Klukinov M
AD  - Department of Anesthesiology, Perioperative and Pain Medicine, School of 
      Medicine, Stanford University, Palo Alto, CA 94304, USA.
FAU - Yan, Ni
AU  - Yan N
AD  - AfaSci Inc., Burlingame, CA 94010, USA.
FAU - Sharma, Kaustubh
AU  - Sharma K
AD  - AfaSci Inc., Burlingame, CA 94010, USA.
FAU - Clark, David J
AU  - Clark DJ
AD  - Department of Anesthesiology, Perioperative and Pain Medicine, School of 
      Medicine, Stanford University, Palo Alto, CA 94304, USA.
AD  - Anesthesiology Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, 
      CA 94304, USA.
FAU - Xie, Xinmin
AU  - Xie X
AD  - AfaSci Inc., Burlingame, CA 94010, USA.
FAU - Yeomans, David C
AU  - Yeomans DC
AUID- ORCID: 0000-0002-9389-8539
AD  - Department of Anesthesiology, Perioperative and Pain Medicine, School of 
      Medicine, Stanford University, Palo Alto, CA 94304, USA.
LA  - eng
GR  - W81XWH2110186/United States Department of Defense/
GR  - Grant/Tonix Pharmaceuticals/
PT  - Journal Article
DEP - 20220521
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC9144867
OTO - NOTNLM
OT  - agonist
OT  - analgesia
OT  - headaches
OT  - magnesium
OT  - oxytocin
OT  - pain
COIS- D.C.Y. is a consultant for Tonix Pharmaceuticals. The remaining authors have no 
      conflict of interest to declare.
EDAT- 2022/05/29 06:00
MHDA- 2022/05/29 06:01
PMCR- 2022/05/21
CRDT- 2022/05/28 01:39
PHST- 2022/04/02 00:00 [received]
PHST- 2022/05/13 00:00 [revised]
PHST- 2022/05/19 00:00 [accepted]
PHST- 2022/05/28 01:39 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/05/29 06:01 [medline]
PHST- 2022/05/21 00:00 [pmc-release]
AID - pharmaceutics14051105 [pii]
AID - pharmaceutics-14-01105 [pii]
AID - 10.3390/pharmaceutics14051105 [doi]
PST - epublish
SO  - Pharmaceutics. 2022 May 21;14(5):1105. doi: 10.3390/pharmaceutics14051105.