PMID- 35631834
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 14
IP  - 10
DP  - 2022 May 11
TI  - pH-Responsive PVA/BC-f-GO Dressing Materials for Burn and Chronic Wound Healing 
      with Curcumin Release Kinetics.
LID - 10.3390/polym14101949 [doi]
LID - 1949
AB  - Polymeric materials have been essential biomaterials to develop hydrogels as 
      wound dressings for sustained drug delivery and chronic wound healing. The 
      microenvironment for wound healing is created by biocompatibility, bioactivity, 
      and physicochemical behavior. Moreover, a bacterial infection often causes the 
      healing process. The bacterial cellulose (BC) was functionalized using graphene 
      oxide (GO) by hydrothermal method to have bacterial 
      cellulose-functionalized-Graphene oxide (BC-f-GO). A simple blending method was 
      used to crosslink BC-f-GO with polyvinyl alcohol (PVA) by tetraethyl 
      orthosilicate (TEOS) as a crosslinker. The structural, morphological, wetting, 
      and mechanical tests were conducted using Fourier-transform infrared spectroscopy 
      (FTIR), Scanning electron microscope (SEM), water contact angle, and a Universal 
      testing machine (UTM). The release of Silver-sulphadiazine and drug release 
      kinetics were studied at various pH levels and using different mathematical 
      models (zero-order, first-order, Higuchi, Hixson, Korsmeyer-Peppas, and 
      Baker-Lonsdale). The antibacterial properties were conducted against 
      Gram-positive and Gram-negative severe infection-causing pathogens. These 
      composite hydrogels presented potential anticancer activities against the U87 
      cell line by an increased GO amount. The result findings show that these 
      composite hydrogels have physical-mechanical and inherent antimicrobial 
      properties and controlled drug release, making them an ideal approach for skin 
      wound healing. As a result, these hydrogels were discovered to be an ideal 
      biomaterial for skin wound healing.
FAU - Al-Arjan, Wafa Shamsan
AU  - Al-Arjan WS
AD  - Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 
      31982, Saudi Arabia.
FAU - Khan, Muhammad Umar Aslam
AU  - Khan MUA
AUID- ORCID: 0000-0001-8105-2651
AD  - Biomedical Research Center, Qatar University, Doha 2713, Qatar.
AD  - Department of Mechanical and Industrial Engineering, Qatar University, Doha 2713, 
      Qatar.
FAU - Almutairi, Hayfa Habes
AU  - Almutairi HH
AD  - Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 
      31982, Saudi Arabia.
FAU - Alharbi, Shadia Mohammed
AU  - Alharbi SM
AD  - Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 
      31982, Saudi Arabia.
FAU - Razak, Saiful Izwan Abd
AU  - Razak SIA
AUID- ORCID: 0000-0001-7477-0284
AD  - BioInspired Device and Tissue Engineering Research Group, School of Biomedical 
      Engineering and Health Sciences, Universiti Teknologi Malaysia, Johor Bahru 
      81300, Johor, Malaysia.
AD  - Centre of Advanced Composite Materials, Faculty of Engineering, Universiti 
      Teknologi Malaysia, Johor Bahru 81300, Johor, Malaysia.
LA  - eng
GR  - AN000593/King Faisal University, Saudi Arabia/
PT  - Journal Article
DEP - 20220511
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC9145507
OTO - NOTNLM
OT  - antibacterial
OT  - biopolymers
OT  - curcumin
OT  - drug delivery
OT  - hydrogels
OT  - pH-responsive
OT  - skin wound healing
COIS- All authors declared no conflict of interest.
EDAT- 2022/05/29 06:00
MHDA- 2022/05/29 06:01
PMCR- 2022/05/11
CRDT- 2022/05/28 01:40
PHST- 2022/04/16 00:00 [received]
PHST- 2022/05/02 00:00 [revised]
PHST- 2022/05/06 00:00 [accepted]
PHST- 2022/05/28 01:40 [entrez]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/05/29 06:01 [medline]
PHST- 2022/05/11 00:00 [pmc-release]
AID - polym14101949 [pii]
AID - polymers-14-01949 [pii]
AID - 10.3390/polym14101949 [doi]
PST - epublish
SO  - Polymers (Basel). 2022 May 11;14(10):1949. doi: 10.3390/polym14101949.