PMID- 35633415
OWN - NLM
STAT- MEDLINE
DCOM- 20220615
LR  - 20240109
IS  - 1573-9104 (Electronic)
IS  - 0921-9668 (Linking)
VI  - 77
IP  - 2
DP  - 2022 Jun
TI  - The Immunomodulating Effect of Phlorotannins from a Brown Alga, Eisenia 
      nipponica, on Mice Stimulated with Ovalbumin through T Cell Regulation.
PG  - 307-316
LID - 10.1007/s11130-022-00974-3 [doi]
AB  - The immunomodulating effect of phlorotannin was investigated in mice stimulated 
      by ovalbumin. When analyzing the main components of phlorotannin concentrate 
      (PTC) from Eisenia nipponica, seven phlorotannins [eckol, 6,6'-bieckol, 
      6,8'-bieckol, 8,8'-bieckol, dieckol, phlorofucofuroeckol (PFF)-A, and PFF-B] were 
      detected. These phlorotannins accounted for approximately 80% of PTC. Oral 
      administration of PTC to mice daily for 21 days reduced serum immunoglobulin E 
      (IgE) and total IgG(1) levels attributable to Th2 cells. The production of 
      splenic cytokines [interleukin (IL)-10 and transforming growth factor-beta1] and 
      Treg cell-mediated expression of forkhead box protein P3 mRNA were significantly 
      increased whereas the production of inflammatory cytokines (interferon-gamma, IL-4, 
      IL-5, and IL-17) by Th1, Th2, and Th17 cells was markedly suppressed. IL-21 
      production and basic leucine zipper ATF-like transcription factor mRNA expression 
      attributable to follicular helper T (Tfh) cells were also suppressed. Flow 
      cytometric analyses demonstrated increased number of Treg cells despite a 
      decrease in the total T cell population. An increase in total B cells was also 
      observed by the flow cytometric analyses in addition to increases in IL-10 
      production, which activates B cells. In contrast, the significantly suppressed 
      production of inflammatory cytokines and moderate increase in Treg cell 
      subpopulation indicated a direct impact of PTC on inflammatory lymphocytes (Th1, 
      Th2, Th17, and Tfh). Thus, PTC may exert antiallergic effects by immunomodulation 
      of T cells and inactivation of inflammatory lymphocyte.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Sugiura, Yoshimasa
AU  - Sugiura Y
AUID- ORCID: 0000-0001-6525-3066
AD  - Department of Food Science and Technology, National Research and Development 
      Agency, Japan Fisheries Research and Education Agency, National Fisheries 
      University, Shimonoseki, Yamaguchi, Japan. ysugiura@fish-u.ac.jp.
FAU - Matsuura, Yuta
AU  - Matsuura Y
AD  - Research Center for Fish Diseases, National Research Institute of Aquaculture, 
      Minami-ise, Mie, Japan.
FAU - Katsuzaki, Hirotaka
AU  - Katsuzaki H
AD  - Graduate School of Bioresources, Mie University, Tsu, Mie, Japan.
FAU - Kakinuma, Makoto
AU  - Kakinuma M
AD  - Graduate School of Bioresources, Mie University, Tsu, Mie, Japan.
FAU - Amano, Hideomi
AU  - Amano H
AD  - Graduate School of Bioresources, Mie University, Tsu, Mie, Japan.
FAU - Usui, Masakatsu
AU  - Usui M
AD  - Department of Food Science and Technology, National Research and Development 
      Agency, Japan Fisheries Research and Education Agency, National Fisheries 
      University, Shimonoseki, Yamaguchi, Japan.
FAU - Tanaka, Ryusuke
AU  - Tanaka R
AD  - Department of Food Science and Technology, National Research and Development 
      Agency, Japan Fisheries Research and Education Agency, National Fisheries 
      University, Shimonoseki, Yamaguchi, Japan.
FAU - Matsushita, Teruo
AU  - Matsushita T
AD  - Department of Food Science and Technology, National Research and Development 
      Agency, Japan Fisheries Research and Education Agency, National Fisheries 
      University, Shimonoseki, Yamaguchi, Japan.
FAU - Miyata, Masaaki
AU  - Miyata M
AD  - Department of Food Science and Technology, National Research and Development 
      Agency, Japan Fisheries Research and Education Agency, National Fisheries 
      University, Shimonoseki, Yamaguchi, Japan.
LA  - eng
GR  - 23880036/Japan Society for the Promotion of Science/
GR  - 25850099/Japan Society for the Promotion of Science/
GR  - 17K07951/Japan Society for the Promotion of Science/
PT  - Journal Article
DEP - 20220528
PL  - Netherlands
TA  - Plant Foods Hum Nutr
JT  - Plant foods for human nutrition (Dordrecht, Netherlands)
JID - 8803554
RN  - 0 (Cytokines)
RN  - 0 (RNA, Messenger)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Cytokines
MH  - Mice
MH  - Ovalbumin
MH  - *Phaeophyceae
MH  - RNA, Messenger
MH  - *T-Lymphocytes
OTO - NOTNLM
OT  - Antiallergy
OT  - Brown algae
OT  - Immunomodulation
OT  - Phlorotannins
EDAT- 2022/05/29 06:00
MHDA- 2022/06/16 06:00
CRDT- 2022/05/28 11:14
PHST- 2022/05/11 00:00 [accepted]
PHST- 2022/05/29 06:00 [pubmed]
PHST- 2022/06/16 06:00 [medline]
PHST- 2022/05/28 11:14 [entrez]
AID - 10.1007/s11130-022-00974-3 [pii]
AID - 10.1007/s11130-022-00974-3 [doi]
PST - ppublish
SO  - Plant Foods Hum Nutr. 2022 Jun;77(2):307-316. doi: 10.1007/s11130-022-00974-3. 
      Epub 2022 May 28.