PMID- 35633917
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1178-7090 (Print)
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 15
DP  - 2022
TI  - Transcriptomic Analysis of Trigeminal Ganglion and Spinal Trigeminal Nucleus 
      Caudalis in Mice with Inflammatory Temporomandibular Joint Pain.
PG  - 1487-1502
LID - 10.2147/JPR.S364887 [doi]
AB  - BACKGROUND: Persistent facial pain heavily impacts the quality of life in 
      patients with temporomandibular joint (TMJ) disorders. Previous studies have 
      demonstrated that long non-coding ribonucleic acid (lncRNA) is an important 
      regulator of pain. In this study, we aimed to analyze lncRNA expression in the 
      whole transcriptome of trigeminal ganglia (TG) and spinal trigeminal nucleus 
      caudalis (Sp5C) in a chronic inflammatory TMJ pain mouse model. METHODS: Chronic 
      inflammatory TMJ pain was induced by intra-TMJ injection of complete Freund's 
      adjuvant (CFA). Mouse TG and Sp5C tissues were harvested on day 4 after CFA 
      injection. The lncRNA expression patterns in the whole transcriptome of TG and 
      Sp5C were profiled with RNA sequencing. RESULTS: We observed that 38 lncRNAs and 
      849 mRNAs were differentially expressed after CFA treatment. Gene Ontology and 
      Kyoto Encyclopedia of Genes and Genomes analysis further revealed relationships 
      among those differentially expressed lncRNAs and mRNAs and their potential 
      functions. Specific categories of biological process, cellular processes, and 
      molecular function of the differentially expressed transcripts were ascertained. 
      CONCLUSION: Our results suggest that lncRNA expression in the whole transcriptome 
      of trigeminal nociceptive system could contribute to the molecular mechanisms 
      that underlie chronic inflammatory TMJ pain.
CI  - (c) 2022 Dong et al.
FAU - Dong, Tieli
AU  - Dong T
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, People's Republic of China.
FAU - Si, Haichao
AU  - Si H
AUID- ORCID: 0000-0002-7198-1729
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, People's Republic of China.
AD  - Department of Anesthesiology, Nanyang Central Hospital, Nanyang, People's 
      Republic of China.
FAU - Li, Zhisong
AU  - Li Z
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, People's Republic of China.
FAU - Bai, Qian
AU  - Bai Q
AUID- ORCID: 0000-0002-0196-8131
AD  - Department of Anesthesiology, The Second Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, People's Republic of China.
FAU - Tao, Feng
AU  - Tao F
AD  - Department of Biomedical Sciences, Texas A&M University College of Dentistry, 
      Dallas, TX, USA.
LA  - eng
PT  - Journal Article
DEP - 20220523
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC9141904
OTO - NOTNLM
OT  - RNA sequencing
OT  - lncRNAs
OT  - spinal trigeminal nucleus caudalis
OT  - temporomandibular joint pain
OT  - trigeminal ganglia
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2022/06/01 06:00
MHDA- 2022/06/01 06:01
PMCR- 2022/05/23
CRDT- 2022/05/31 09:48
PHST- 2022/03/03 00:00 [received]
PHST- 2022/05/17 00:00 [accepted]
PHST- 2022/05/31 09:48 [entrez]
PHST- 2022/06/01 06:00 [pubmed]
PHST- 2022/06/01 06:01 [medline]
PHST- 2022/05/23 00:00 [pmc-release]
AID - 364887 [pii]
AID - 10.2147/JPR.S364887 [doi]
PST - epublish
SO  - J Pain Res. 2022 May 23;15:1487-1502. doi: 10.2147/JPR.S364887. eCollection 2022.