PMID- 35634661
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220602
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 38
IP  - 1
DP  - 2022 Jan
TI  - [Effects of early life PM(2.5) exposure on prefrontal cortex of offspring male 
      rats].
PG  - 1-5
LID - 10.12047/j.cjap.6222.2022.001 [doi]
AB  - Objective: To investigate the effects of PM(2.5) exposure at different stages of 
      early life on the prefrontal cortex of offspring rats. Methods: Twelve pregnant 
      SD rats were randomly divided into four groups: Control group (CG), Maternal 
      pregnancy exposure group (MG), Early postnatal exposure group (EP) and Perinatal 
      period exposure group (PP), 3 rats in each group. The pregnant and offspring rats 
      were exposed to clean air or 8-fold concentrated PM(2.5). MG was exposed from 
      gestational day (GD) 1 to GD21. EP was exposed from postnatal day (PND) 1 to 
      PND21, and PP was exposed from GD1 to PND21. After exposure, the prefrontal 
      cortex of 6 offspring rats in each group was analyzed. HE staining was used to 
      observe the pathological damage in the prefrontal cortex. ELISA was employed to 
      detect neuroinflammatory factors, and HPLC/MSC was applied to determine 
      neurotransmitter content. Western blot and colorimetry were applied for detecting 
      astrocyte markers and oxidative stress markers, respectively. Results: Compared 
      with MG and CG, the pathological changes of prefrontal cortex in PP and EP were 
      more obvious. Compared with MG and CG, the neuroinflammatory factors (IL-1, IL-6, 
      TNF-alpha) in PP and EP were increased significantly (P＜0.01), the level of MT were 
      decreased significantly (P＜0.05), and the level of oxytocin (OT) showed a 
      downward trend; the level of neurotransmitter ACh was also increased 
      significantly (P＜0.01). Compared with MG and CG, the GFAP level of PP and EP 
      showed an upward trend, the level of oxidative stress index SOD in PP and EP was 
      decreased significantly (P＜0.01), and the level of ROS was increased 
      significantly (P＜0.01). Compared with the offspring rats of CG and MG, the CAT 
      level of PP was decreased significantly (P＜0.01, P＜0.05). Compared with the 
      offspring rats of CG, the CAT level of EP was decreased significantly (P＜0.05). 
      There was no significant difference in IL-1, IL-6, TNF-alpha, MT, OT, ACh, GFAP, SOD, 
      ROS and CAT levels between PP and EP, or MG and CG. Conclusion: PM(2.5) exposure 
      in early life has adverse effects on the prefrontal cortex of offspring male 
      rats, and early birth exposure may be more sensitive.
FAU - Liang, Xiao-Tian
AU  - Liang XT
AD  - School of Public Health and Management, Binzhou Medical College, Yantai 264000.
AD  - Institute of Environmental Medicine and Occupational Medicine, Academy of 
      Military Medicine, Academy of Military Sciences, Tianjin 300050, China.
FAU - Han, Chun-Lei
AU  - Han CL
AD  - School of Public Health and Management, Binzhou Medical College, Yantai 264000.
FAU - Lin, Ben-Cheng
AU  - Lin BC
AD  - Institute of Environmental Medicine and Occupational Medicine, Academy of 
      Military Medicine, Academy of Military Sciences, Tianjin 300050, China.
FAU - Shi, Yue
AU  - Shi Y
AD  - Institute of Environmental Medicine and Occupational Medicine, Academy of 
      Military Medicine, Academy of Military Sciences, Tianjin 300050, China.
FAU - Xie, Xiao-Qian
AU  - Xie XQ
AD  - School of Public Health and Management, Binzhou Medical College, Yantai 264000.
AD  - Institute of Environmental Medicine and Occupational Medicine, Academy of 
      Military Medicine, Academy of Military Sciences, Tianjin 300050, China.
FAU - Li, Kang
AU  - Li K
AD  - Institute of Environmental Medicine and Occupational Medicine, Academy of 
      Military Medicine, Academy of Military Sciences, Tianjin 300050, China.
FAU - Xi, Zhu-Ge
AU  - Xi ZG
AD  - School of Public Health and Management, Binzhou Medical College, Yantai 264000.
AD  - Institute of Environmental Medicine and Occupational Medicine, Academy of 
      Military Medicine, Academy of Military Sciences, Tianjin 300050, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Particulate Matter)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Female
MH  - Interleukin-1/pharmacology
MH  - *Interleukin-6
MH  - Male
MH  - Neurotransmitter Agents
MH  - Particulate Matter/toxicity
MH  - Prefrontal Cortex
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reactive Oxygen Species
MH  - Superoxide Dismutase
MH  - *Tumor Necrosis Factor-alpha/pharmacology
OTO - NOTNLM
OT  - PM2.5
OT  - neurodevelopment
OT  - prefrontal cortex
OT  - sensitive period
EDAT- 2022/06/01 06:00
MHDA- 2022/06/03 06:00
CRDT- 2022/05/31 10:04
PHST- 2022/05/31 10:04 [entrez]
PHST- 2022/06/01 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
AID - 10.12047/j.cjap.6222.2022.001 [doi]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2022 Jan;38(1):1-5. doi: 
      10.12047/j.cjap.6222.2022.001.