PMID- 35635073
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20220907
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 85
IP  - 18
DP  - 2022 Sep 17
TI  - An exploratory study; the gap between real reference interval and currently used 
      reference interval of RBC AChE activities in South Korea.
PG  - 739-749
LID - 10.1080/15287394.2022.2080133 [doi]
AB  - The current reference interval (RI) FOR red blood cell acetylcholinesterase (RBC 
      AChE) activity in South Korea was established with data obtained from populations 
      outside the country. The aim of this study was to assess the transferability of 
      current RI of RBC AChE activity for organophosphate (OP) poisoning and determine 
      the biological characteristics, real RI, and interindividual variation in RBC 
      AChE activity in South Korea. Data were retrospectively collected for RBC AChE 
      activity as measured by the modified Ellman's method for 782 patients who 
      presented to our hospital. The clinical course did not differ significantly with 
      the degree of deviation of RBC AChE activity from the currently used RI in 195 
      patients exposed to OP. RBC AChE activity was associated with gender and smoking 
      status but not age or body mass index (BMI); however, a regression model 
      incorporating age, gender, smoking status and BMI explained only a small portion 
      of the variance in RBC AChE activity in South Korea. The RI of RBC AChE activity 
      was 9,403-16,825 U/L, with 13.9% interindividual variation. The range of RBC AChE 
      activity in South Korea is wider than RI currently used in clinical practice and 
      exhibited a high degree of interindividual variation. In the absence of 
      collecting pre-exposure values, it is recommended to conduct serial measurements, 
      rather than one-point measurements, of RBC AChE activity as evidenced by the RI 
      in OP poisoning.
FAU - Seong, Yeonji
AU  - Seong Y
AUID- ORCID: 0000-0002-9796-3211
AD  - Department of Emergency Medicine, Chonnam National University Medical School, 
      Gwangju, South Korea.
FAU - Moon, Jeongmi
AU  - Moon J
AUID- ORCID: 0000-0002-9182-5475
AD  - Department of Emergency Medicine, Chonnam National University Medical School, 
      Gwangju, South Korea.
FAU - Chun, Byeongjo
AU  - Chun B
AUID- ORCID: 0000-0002-5240-4213
AD  - Department of Emergency Medicine, Chonnam National University Medical School, 
      Gwangju, South Korea.
FAU - Cho, Yongsoo
AU  - Cho Y
AUID- ORCID: 0000-0001-8306-2298
AD  - Department of Emergency Medicine, Chonnam National University Medical School, 
      Gwangju, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20220529
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Cholinesterase Inhibitors)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - *Acetylcholinesterase
MH  - Cholinesterase Inhibitors
MH  - Erythrocytes
MH  - Humans
MH  - *Organophosphate Poisoning
MH  - Reference Values
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Organophosphate
OT  - acetylcholinesterase
OT  - poisoning
OT  - reference interval
EDAT- 2022/06/01 06:00
MHDA- 2022/07/14 06:00
CRDT- 2022/05/31 11:30
PHST- 2022/06/01 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/05/31 11:30 [entrez]
AID - 10.1080/15287394.2022.2080133 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2022 Sep 17;85(18):739-749. doi: 
      10.1080/15287394.2022.2080133. Epub 2022 May 29.