PMID- 35636325
OWN - NLM
STAT- MEDLINE
DCOM- 20220621
LR  - 20220621
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 216
DP  - 2022 Aug
TI  - The Nanostructured lipid carrier gel of Oroxylin A reduced UV-induced skin 
      oxidative stress damage.
PG  - 112578
LID - S0927-7765(22)00261-2 [pii]
LID - 10.1016/j.colsurfb.2022.112578 [doi]
AB  - Oxidative stress damage caused by sun exposure damages the appearance and 
      function of the skin, which is one of the essential inducements of skin aging and 
      even leads to skin cancer. Oroxylin A (OA) is a flavonoid with excellent 
      antioxidant activity and has protective effects against photoaging induced by UV 
      irradiation. However, the strong barrier function of the skin stratum corneum 
      prevents transdermal absorption of the drug, which limits the application of OA 
      in dermal drug delivery. Studies have shown that nanostructured lipid carriers 
      (NLC) can promote not only transdermal absorption of drugs but also increase drug 
      stability and control drug release efficiency, which has broad prospects for 
      clinical applications. In this paper, NLC loaded with OA (OA-NLC) was prepared in 
      order to improve the skin permeability and stability of OA. In vitro studies 
      revealed that OA-NLC had better therapeutic effects than OA solution (OA-Sol) in 
      the cellular model of UVB radiation. OA-Sol and OA-NLC were immobilized in a 
      hydrogel matrix to facilitate application to the dorsal skin of mice. It was 
      found that OA-NLC-gel showed significant antioxidant and anti-apoptotic activity 
      compared to OA-Sol-gel, which was able to protect against skin damage in mice 
      after UV radiation. These results suggest that OA-NLC can improve the 
      deficiencies of OA in skin delivery and show better resistance to UV-induced 
      oxidative damage. The application of OA-NLC to skin delivery systems has good 
      prospects and deserves further development and investigation.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Zhu, Shan
AU  - Zhu S
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China.
FAU - Zhao, Zhiyue
AU  - Zhao Z
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China; Engineering 
      Research Center of Modern Chinese Medicine Discovery and Preparation Technique, 
      Ministry of Education, Tianjin University of Traditional Chinese Medicine, 
      Tianjin 301617, China.
FAU - Qin, Wenxiao
AU  - Qin W
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China.
FAU - Liu, Tao
AU  - Liu T
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China.
FAU - Yang, Yi
AU  - Yang Y
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China.
FAU - Wang, Zijing
AU  - Wang Z
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China.
FAU - Ma, Hongfei
AU  - Ma H
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China; Engineering 
      Research Center of Modern Chinese Medicine Discovery and Preparation Technique, 
      Ministry of Education, Tianjin University of Traditional Chinese Medicine, 
      Tianjin 301617, China.
FAU - Wang, Xiang
AU  - Wang X
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China.
FAU - Liu, Tao
AU  - Liu T
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China.
FAU - Qi, Dongli
AU  - Qi D
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China; Engineering 
      Research Center of Modern Chinese Medicine Discovery and Preparation Technique, 
      Ministry of Education, Tianjin University of Traditional Chinese Medicine, 
      Tianjin 301617, China.
FAU - Guo, Pan
AU  - Guo P
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China; Engineering 
      Research Center of Modern Chinese Medicine Discovery and Preparation Technique, 
      Ministry of Education, Tianjin University of Traditional Chinese Medicine, 
      Tianjin 301617, China.
FAU - Pi, JiaXin
AU  - Pi J
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China; Engineering 
      Research Center of Modern Chinese Medicine Discovery and Preparation Technique, 
      Ministry of Education, Tianjin University of Traditional Chinese Medicine, 
      Tianjin 301617, China.
FAU - Tian, BaoCheng
AU  - Tian B
AD  - School of Pharmacy, Binzhou Medical University, 346 Guanhai Road, Yantai 264003, 
      China.
FAU - Zhang, Han
AU  - Zhang H
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic 
      address: zhanghan0023@126.com.
FAU - Li, Nan
AU  - Li N
AD  - State Key laboratory of Component Traditional Chinese Medicine, Tianjin 
      University of Traditional Chinese Medicine, Tianjin 301617, China; Engineering 
      Research Center of Modern Chinese Medicine Discovery and Preparation Technique, 
      Ministry of Education, Tianjin University of Traditional Chinese Medicine, 
      Tianjin 301617, China. Electronic address: linan@tjutcm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220517
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Drug Carriers)
RN  - 0 (Excipients)
RN  - 0 (Flavonoids)
RN  - 0 (Lipids)
RN  - 53K24Z586G (5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one)
SB  - IM
MH  - Animals
MH  - *Drug Carriers
MH  - Excipients
MH  - Flavonoids/metabolism/pharmacology
MH  - Lipids
MH  - Mice
MH  - *Nanostructures
MH  - Oxidative Stress
MH  - Particle Size
MH  - Skin/metabolism
MH  - Ultraviolet Rays
OTO - NOTNLM
OT  - Antioxidant
OT  - Nanostructured lipid carrier
OT  - Oroxylin A
OT  - Oxidative skin damage
OT  - Transdermal drug delivery
EDAT- 2022/06/01 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/05/31 13:17
PHST- 2022/02/25 00:00 [received]
PHST- 2022/05/09 00:00 [revised]
PHST- 2022/05/13 00:00 [accepted]
PHST- 2022/06/01 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/05/31 13:17 [entrez]
AID - S0927-7765(22)00261-2 [pii]
AID - 10.1016/j.colsurfb.2022.112578 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2022 Aug;216:112578. doi: 
      10.1016/j.colsurfb.2022.112578. Epub 2022 May 17.