PMID- 35637108
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20221221
IS  - 1460-9584 (Electronic)
IS  - 1268-7731 (Linking)
VI  - 28
IP  - 8
DP  - 2022 Dec
TI  - Normal saline injection produces a therapeutic effect in patients with plantar 
      fasciitis: A systematic review and meta-analysis of randomized controlled trials.
PG  - 1129-1138
LID - S1268-7731(22)00087-X [pii]
LID - 10.1016/j.fas.2022.04.005 [doi]
AB  - BACKGROUND: Injectable therapies have been increasingly investigated to treat 
      plantar fasciitis in randomized controlled trials (RCT) where normal saline 
      injections are frequently used as placebo. The purpose was to quantify the effect 
      of saline injections and compared against available minimal clinically important 
      difference (MCID) criteria specific for plantar fasciitis to assess if changes 
      were clinically meaningful. METHODS: RCT including a placebo group (normal 
      saline) and reporting changes in pain and functional outcomes in plantar 
      fasciitis were identified through a search in MEDLINE, Embase, Web of Science, 
      and Scopus to February 2022. PRISMA guidelines and a registered protocol 
      (PROSPERO: CRD42020214035) were followed to conduct the study. RESULTS: Pooled 
      analysis of 13 RCT (379 subjects) included for analysis revealed a significant 
      improvement on pain (P < .00001) and functional scores (P < .00001) after normal 
      saline injections. These changes exceeded the established MCID criteria. 
      CONCLUSIONS: Normal saline injections in plantar fasciitis showed a therapeutic 
      effect with statistically and clinically meaningful improvement when administered 
      in the setting of an RCT for up to 12 months. The control of potential 
      confounders influencing the effect of saline injections is required for future 
      research.
CI  - Copyright (c) 2022 European Foot and Ankle Society. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Pena-Martinez, Victor Manuel
AU  - Pena-Martinez VM
AD  - Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, "Dr. 
      Jose Eleuterio Gonzalez" University Hospital, Monterrey, Mexico.
FAU - Acosta-Olivo, Carlos
AU  - Acosta-Olivo C
AD  - Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, "Dr. 
      Jose Eleuterio Gonzalez" University Hospital, Monterrey, Mexico.
FAU - Tamez-Mata, Yadira
AU  - Tamez-Mata Y
AD  - Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, "Dr. 
      Jose Eleuterio Gonzalez" University Hospital, Monterrey, Mexico.
FAU - Simental-Mendia, Luis E
AU  - Simental-Mendia LE
AD  - Instituto Mexicano del Seguro Social, Biomedical Research Unit, Delegacion 
      Durango, Durango, Mexico.
FAU - Blazquez-Saldana, Jaime
AU  - Blazquez-Saldana J
AD  - Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, "Dr. 
      Jose Eleuterio Gonzalez" University Hospital, Monterrey, Mexico.
FAU - Vilchez-Cavazos, Felix
AU  - Vilchez-Cavazos F
AD  - Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, "Dr. 
      Jose Eleuterio Gonzalez" University Hospital, Monterrey, Mexico.
FAU - Simental-Mendia, Mario
AU  - Simental-Mendia M
AD  - Universidad Autonoma de Nuevo Leon, Orthopedics and Traumatology Service, "Dr. 
      Jose Eleuterio Gonzalez" University Hospital, Monterrey, Mexico. Electronic 
      address: mario.simentalme@uanl.edu.mx.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20220429
PL  - France
TA  - Foot Ankle Surg
JT  - Foot and ankle surgery : official journal of the European Society of Foot and 
      Ankle Surgeons
JID - 9609647
RN  - 0 (Saline Solution)
SB  - IM
MH  - Humans
MH  - *Saline Solution
MH  - Randomized Controlled Trials as Topic
MH  - *Fasciitis, Plantar/therapy
MH  - Injections
MH  - Pain
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Injections
OT  - Meta-analysis
OT  - Placebo
OT  - Plantar fasciitis
OT  - Saline
OT  - Systematic review
EDAT- 2022/06/01 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/05/31 13:42
PHST- 2022/01/27 00:00 [received]
PHST- 2022/03/15 00:00 [revised]
PHST- 2022/04/20 00:00 [accepted]
PHST- 2022/06/01 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/05/31 13:42 [entrez]
AID - S1268-7731(22)00087-X [pii]
AID - 10.1016/j.fas.2022.04.005 [doi]
PST - ppublish
SO  - Foot Ankle Surg. 2022 Dec;28(8):1129-1138. doi: 10.1016/j.fas.2022.04.005. Epub 
      2022 Apr 29.