PMID- 35639037
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220602
IS  - 1899-1505 (Electronic)
IS  - 0867-5910 (Linking)
VI  - 73
IP  - 1
DP  - 2022 Feb
TI  - Are insulin resistance and non-alcoholic fatty liver disease associated with 
      Peyronie's disease? A pilot study.
LID - 10.26402/jpp.2022.1.05 [doi]
AB  - Risk factors for Peyronie's disease (PD) are serum lipid abnormalities, 
      hypertension and type 2 diabetes mellitus (T2DM). Oxidative stress and 
      inflammation are key-players in the pathogenesis of arterial diseases, leading to 
      insulin resistance (IR), which is a major determinant of non-alcoholic fatty 
      liver disease (NAFLD). We studied the potential relationship between PD, IR, and 
      NAFLD. Forty-nine male patients were enrolled, fulfilling the well-accepted 
      diagnostic criteria of stable PD. Fifty male individuals without PD, well-matched 
      for age and BMI, were selected as the control group. Comorbidities (T2DM and 
      hypertension), as well as the lipid profile and the glucometabolic asset, were 
      evaluated. The triglycerides/HDL ratio (TG/HDL-C ratio) with a cut-off of >/=3 and 
      the triglycerides-glucose index (TyG) with an optimal cut-point of 8.5 were used 
      for diagnosis of IR and NAFLD, respectively. NAFLD diagnosis was confirmed by the 
      presence of bright liver at ultrasonography. Hypertension was found more 
      frequently in PD patients than in no-PD subjects (P=0.017), independently of age 
      (P=0.99). Both IR and NAFLD were significantly associated with the presence of PD 
      in our population of men (P=0.043 and 0.0001, respectively), no matter how old 
      (P=0.11 and 0.74, respectively). At logistic regression, NAFLD was the only 
      predictor of the PD presence (p=0.021). The AUROC of TyG to predict PD was 0.7437 
      (sensitivity 67.35% and specificity 80%) with a percentage of correctly 
      classified patients of 73.74%. Oxidative stress markers were significantly 
      associated with NAFLD. Testosterone level was significantly low in the subjects 
      with NAFLD in cross-sectional analyses. Both factors, i.e., oxidative stress and 
      hypogonadism, are central to PD pathogenesis. In conclusion, NAFLD and IR are 
      strongly associated with PD. The pathogenic link between these conditions and the 
      underlying mechanisms are only hypothetical and thoroughly summarized in the 
      discussion.
FAU - Crocetto, F
AU  - Crocetto F
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II", Naples, Italy.
FAU - Barone, B
AU  - Barone B
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II", Naples, Italy. biagio.barone@unina.it.
FAU - Manfredi, C
AU  - Manfredi C
AD  - Department of Woman Child and of General and Specialist Surgery, University of 
      Campania "Luigi Vanvitelli", Naples, Italy.
FAU - Trama, F
AU  - Trama F
AD  - Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of 
      Perugia, Terni, Italy.
FAU - Romano, L
AU  - Romano L
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II", Naples, Italy.
FAU - Romeo, M
AU  - Romeo M
AD  - Hepatogastroenterology Division, Department of Precision Medicine, University of 
      Campania "Luigi Vanvitelli", Naples, Italy.
FAU - Russo, G
AU  - Russo G
AD  - Department of Public Health, University of Naples Federico II, Naples, Italy.
FAU - Sicignano, E
AU  - Sicignano E
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II", Naples, Italy.
FAU - Persico, F
AU  - Persico F
AD  - Department of Urology, A.O.R.N. A. Cardarelli, Naples, Italy.
FAU - Aveta, A
AU  - Aveta A
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II", Naples, Italy.
FAU - Spirito, L
AU  - Spirito L
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II", Naples, Italy.
FAU - Napolitano, L
AU  - Napolitano L
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II", Naples, Italy.
FAU - Imbimbo, C
AU  - Imbimbo C
AD  - Department of Neurosciences, Reproductive Sciences and Odontostomatology, 
      University of Naples "Federico II", Naples, Italy.
FAU - Tarantino, G
AU  - Tarantino G
AD  - Department of Clinical Medicine and Surgery, University of Naples "Federico II", 
      Naples, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220527
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
RN  - 0 (Triglycerides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Glucose
MH  - Humans
MH  - *Hypertension
MH  - *Insulin Resistance
MH  - Male
MH  - *Non-alcoholic Fatty Liver Disease
MH  - *Penile Induration/complications
MH  - Pilot Projects
MH  - Triglycerides
EDAT- 2022/06/01 06:00
MHDA- 2022/06/03 06:00
CRDT- 2022/05/31 15:26
PHST- 2022/01/06 00:00 [received]
PHST- 2022/02/28 00:00 [accepted]
PHST- 2022/05/31 15:26 [entrez]
PHST- 2022/06/01 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
AID - 10.26402/jpp.2022.1.05 [doi]
PST - ppublish
SO  - J Physiol Pharmacol. 2022 Feb;73(1). doi: 10.26402/jpp.2022.1.05. Epub 2022 May 
      27.