PMID- 35640467
OWN - NLM
STAT- MEDLINE
DCOM- 20220617
LR  - 20220920
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 243
DP  - 2022 Jun
TI  - Urinary 3-phenoxybenzoic acid (3-PBA) levels and changes in hematological 
      parameters in Korean adult population: A Korean National Environmental Health 
      Survey (KoNEHS) 2012-2014 analysis.
PG  - 113988
LID - S1438-4639(22)00071-2 [pii]
LID - 10.1016/j.ijheh.2022.113988 [doi]
AB  - Pyrethroid insecticides have been broadly used as pest control in agriculture and 
      residential spaces, exerting high effectiveness of insecticidal property and 
      relatively low toxicity to humans. Several animal studies suggested that exposure 
      to pyrethroids may induce hematological abnormalities, thereby altering the 
      number of blood cells and resulting in blood disorders. However, no epidemiologic 
      study has reported on the effect of pyrethroid insecticide exposure on 
      hematological changes, except for occupational exposure. This study aimed to 
      investigate the effect of urinary 3-phenoxybenzoic acid (3-PBA) concentrations on 
      hematological parameters in a representative South Korean adult population. We 
      analyzed data from 6296 adults enrolled in the Korean National Environmental 
      Health Survey (2012-2014). We employed multiple linear regression analysis to 
      evaluate the association of urinary 3-PBA levels with eight hematological 
      profiles: white blood cells (WBCs), red blood cells (RBCs), hemoglobin, 
      hematocrit, platelets, mean corpuscular volume (MCV), mean corpuscular hemoglobin 
      (MCH), and mean corpuscular hemoglobin concentration (MCHC). The urinary 3-PBA 
      levels were negatively associated with WBC, RBC, and hemoglobin levels and 
      positively associated with MCV levels. The direction and magnitude of the 
      association between the 3-PBA and hematological parameters varied according to 
      sex and age. The adverse effects of 3-PBA on hematological parameters were 
      distinctive among males aged 60 years and older. In this age group, 3-PBA levels 
      were negatively associated with the WBC, RBC, hemoglobin, hematocrit, and MCHC 
      levels among males. This study is the first to verify that urinary 3-PBA 
      concentrations at the levels found in a Korean population are associated with 
      blood parameters. This finding merits further investigation to understand the 
      impact of 3-PBA on human blood function and public health.
CI  - Copyright (c) 2022 Elsevier GmbH. All rights reserved.
FAU - Choi, Yun-Hee
AU  - Choi YH
AD  - Department of Health and Safety Convergence Science, Korea University, Anam-ro 
      145, Seongbuk-gu, Seoul, 02841, South Korea; BK21 FOUR R & E Center for Learning 
      Health System, Korea University, Anam-ro 145, Seongbuk-gu, Seoul, 02841, South 
      Korea.
FAU - Lee, Ju-Yeon
AU  - Lee JY
AD  - Department of Health and Safety Convergence Science, Korea University, Anam-ro 
      145, Seongbuk-gu, Seoul, 02841, South Korea; BK21 FOUR R & E Center for Learning 
      Health System, Korea University, Anam-ro 145, Seongbuk-gu, Seoul, 02841, South 
      Korea.
FAU - Huh, Da-An
AU  - Huh DA
AD  - Institute of Health Sciences, Korea University, Anam-ro 145, Seongbuk-gu, Seoul 
      02841, South Korea.
FAU - Moon, Kyong Whan
AU  - Moon KW
AD  - BK21 FOUR R & E Center for Learning Health System, Korea University, Anam-ro 145, 
      Seongbuk-gu, Seoul, 02841, South Korea; Department of Health and Environmental 
      Science, Korea University, Anam-ro 145, Seongbuk-gu, Seoul, 02841, South Korea. 
      Electronic address: kwmoon@korea.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20220528
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Benzoates)
RN  - 0 (Pyrethrins)
RN  - 69DC2655VH (3-phenoxybenzoic acid)
SB  - IM
MH  - Animals
MH  - Benzoates/urine
MH  - Environmental Health
MH  - Male
MH  - *Pyrethrins/urine
MH  - Republic of Korea
OTO - NOTNLM
OT  - 3-phenoxybenzoic acid (3-PBA)
OT  - Hematological parameters
OT  - Insecticide
OT  - Korean National Environmental Health Survey (KoNEHS)
OT  - Pyrethroid
EDAT- 2022/06/01 06:00
MHDA- 2022/06/18 06:00
CRDT- 2022/05/31 18:24
PHST- 2022/03/02 00:00 [received]
PHST- 2022/05/17 00:00 [revised]
PHST- 2022/05/22 00:00 [accepted]
PHST- 2022/06/01 06:00 [pubmed]
PHST- 2022/06/18 06:00 [medline]
PHST- 2022/05/31 18:24 [entrez]
AID - S1438-4639(22)00071-2 [pii]
AID - 10.1016/j.ijheh.2022.113988 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2022 Jun;243:113988. doi: 10.1016/j.ijheh.2022.113988. 
      Epub 2022 May 28.