PMID- 35640594
OWN - NLM
STAT- MEDLINE
DCOM- 20230407
LR  - 20230412
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Print)
IS  - 0305-1048 (Linking)
VI  - 50
IP  - W1
DP  - 2022 Jul 5
TI  - AllerCatPro 2.0: a web server for predicting protein allergenicity potential.
PG  - W36-W43
LID - 10.1093/nar/gkac446 [doi]
AB  - Proteins in food and personal care products can pose a risk for an immediate 
      immunoglobulin E (IgE)-mediated allergic response. Bioinformatic tools can assist 
      to predict and investigate the allergenic potential of proteins. Here we present 
      AllerCatPro 2.0, a web server that can be used to predict protein allergenicity 
      potential with better accuracy than other computational methods and new features 
      that help assessors making informed decisions. AllerCatPro 2.0 predicts the 
      similarity between input proteins using both their amino acid sequences and 
      predicted 3D structures towards the most comprehensive datasets of reliable 
      proteins associated with allergenicity. These datasets currently include 4979 
      protein allergens, 162 low allergenic proteins, and 165 autoimmune allergens with 
      manual expert curation from the databases of WHO/International Union of 
      Immunological Societies (IUIS), Comprehensive Protein Allergen Resource 
      (COMPARE), Food Allergy Research and Resource Program (FARRP), UniProtKB and 
      Allergome. Various examples of profilins, autoimmune allergens, low allergenic 
      proteins, very large proteins, and nucleotide input sequences showcase the 
      utility of AllerCatPro 2.0 for predicting protein allergenicity potential. The 
      AllerCatPro 2.0 web server is freely accessible at 
      https://allercatpro.bii.a-star.edu.sg.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic 
      Acids Research.
FAU - Nguyen, Minh N
AU  - Nguyen MN
AUID- ORCID: 0000-0003-4949-2571
AD  - Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix 138671, Singapore.
AD  - IFCS Programme, Singapore Institute for Food and Biotechnology Innovation, Agency 
      for Science, Technology and Research, Singapore.
FAU - Krutz, Nora L
AU  - Krutz NL
AD  - NV Procter & Gamble Services Company SA, Strombeek-Bever, Belgium.
FAU - Limviphuvadh, Vachiranee
AU  - Limviphuvadh V
AD  - Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix 138671, Singapore.
AD  - IFCS Programme, Singapore Institute for Food and Biotechnology Innovation, Agency 
      for Science, Technology and Research, Singapore.
FAU - Lopata, Andreas L
AU  - Lopata AL
AD  - Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix 138671, Singapore.
AD  - Molecular Allergy Research Laboratory, Australian Institute of Tropical Health 
      and Medicine, James Cook University, Townsville, QLD, Australia.
AD  - Tropical Futures Institute, James Cook University, Singapore.
FAU - Gerberick, G Frank
AU  - Gerberick GF
AD  - GF3 Consultancy LLC, West Chester, OH, USA.
FAU - Maurer-Stroh, Sebastian
AU  - Maurer-Stroh S
AUID- ORCID: 0000-0003-0813-9640
AD  - Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix 138671, Singapore.
AD  - IFCS Programme, Singapore Institute for Food and Biotechnology Innovation, Agency 
      for Science, Technology and Research, Singapore.
AD  - Department of Biological Sciences, National University of Singapore, 14 Science 
      Drive 4, 117543, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - 0 (Allergens)
RN  - 0 (Proteins)
RN  - 0 (Cosmetics)
SB  - IM
MH  - Humans
MH  - *Allergens/chemistry/immunology
MH  - Amino Acid Sequence
MH  - *Computers
MH  - Food Hypersensitivity/etiology/immunology
MH  - *Proteins/chemistry/immunology
MH  - *Internet
MH  - Cosmetics/adverse effects/chemistry
MH  - *Software
MH  - Protein Conformation
MH  - Datasets as Topic
PMC - PMC9252832
EDAT- 2022/06/01 06:00
MHDA- 2023/04/05 06:42
PMCR- 2022/05/30
CRDT- 2022/05/31 18:42
PHST- 2022/05/11 00:00 [accepted]
PHST- 2022/05/07 00:00 [revised]
PHST- 2022/03/21 00:00 [received]
PHST- 2023/04/05 06:42 [medline]
PHST- 2022/06/01 06:00 [pubmed]
PHST- 2022/05/31 18:42 [entrez]
PHST- 2022/05/30 00:00 [pmc-release]
AID - 6595260 [pii]
AID - gkac446 [pii]
AID - 10.1093/nar/gkac446 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2022 Jul 5;50(W1):W36-W43. doi: 10.1093/nar/gkac446.