PMID- 35641174
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 152
IP  - 9
DP  - 2022 Sep 6
TI  - Biomarkers of Fruit Intake Using a Targeted Metabolomics Approach: an 
      Observational Cross-Sectional Analysis of the ELSA-Brasil Study.
PG  - 2023-2030
LID - 10.1093/jn/nxac115 [doi]
AB  - BACKGROUND: Advances in technology have led to the identification of a greater 
      number of metabolites related to diet. Although fruit intake biomarkers have been 
      reported in some studies, these findings require further replication, considering 
      the relevance of fruits for diet quality and health. OBJECTIVES: The aim of this 
      study was to explore the associations of a set of potential urinary biomarkers of 
      diet, assessed using a targeted metabolomics approach, with self-reported fruit 
      intake data in participants of a computer-assisted 24-h dietary recall (GloboDiet 
      software) validation study. METHODS: A total of 93 individuals aged 43-72 y, 54% 
      female, participated in this study. The subjects were a subsample of the 
      Longitudinal Study of Adult Health (ELSA-Brasil). A 24-h dietary recall was 
      obtained with the aid of GloboDiet software matching a 24-h urine sample from 
      each participant. Candidate biomarkers were selected in a literature search and 
      identified in urine by LC coupled to high-resolution MS. Spearman correlation 
      analyses were performed between fruit intake and each biomarker. RESULTS: 
      Spearman correlation analysis showed that total fruits intake was significantly 
      correlated with citric acid (rho = 0.213, P = 0.041), ferulic acid sulfate I 
      (rho = 0.240, P = 0.020), hesperetin glucuronide/homoeriodictyol glucuronide 
      (rho = 0.303, P = 0.003), hydroxyhippuric acid (rho = 0.239, P = 0.021), homovanillic 
      alcohol sulfate (rho = 0.339, P = 0.001), methylgallic acid sulfate (rho = 0.268, 
      P = 0.009), naringenin glucuronide (NG; rho = 0.278, P = 0.007), proline betaine 
      (PB; rho = 0.305, P = 0.003), syringic acid sulfate (rho = 0.210, P = 0.044), and 
      sinapic acid sulfate (rho = 0.412, P < 0.001). Among them, 3 have been described in 
      literature as promising biomarkers for intake of total fruit, oranges, and citrus 
      fruit: NG, hesperetin glucuronide, and PB. CONCLUSIONS: Associations of total 
      fruits intake with urinary measurements indicate the potential usefulness of 
      dietary biomarkers in the Brazilian population as a complement to self-reported 
      dietary assessments.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      American Society for Nutrition.
FAU - Levy, Jessica
AU  - Levy J
AUID- ORCID: 0000-0002-4037-3931
AD  - Department of Nutrition, School of Public Health, University of Sao Paulo, Sao 
      Paulo, Brazil.
FAU - Silva, Alexsandro Macedo
AU  - Silva AM
AD  - Department of Nutrition, School of Public Health, University of Sao Paulo, Sao 
      Paulo, Brazil.
FAU - De Carli, Eduardo
AU  - De Carli E
AD  - Department of Nutrition, School of Public Health, University of Sao Paulo, Sao 
      Paulo, Brazil.
FAU - Cacau, Leandro Teixeira
AU  - Cacau LT
AUID- ORCID: 0000-0003-1681-5960
AD  - Department of Nutrition, School of Public Health, University of Sao Paulo, Sao 
      Paulo, Brazil.
FAU - de Alvarenga, Jose Fernando Rinaldi
AU  - de Alvarenga JFR
AD  - Food Research Center (FoRC), Department of Food and Experimental Nutrition, 
      School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
FAU - Fiamoncini, Jarlei
AU  - Fiamoncini J
AD  - Food Research Center (FoRC), Department of Food and Experimental Nutrition, 
      School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
FAU - Bensenor, Isabela Martins
AU  - Bensenor IM
AD  - Clinical and Epidemiological Research Center, University Hospital, University of 
      Sao Paulo, Sao Paulo, Brazil.
FAU - Lotufo, Paulo Andrade
AU  - Lotufo PA
AD  - Clinical and Epidemiological Research Center, University Hospital, University of 
      Sao Paulo, Sao Paulo, Brazil.
FAU - Marchioni, Dirce Maria
AU  - Marchioni DM
AUID- ORCID: 0000-0002-6810-5779
AD  - Department of Nutrition, School of Public Health, University of Sao Paulo, Sao 
      Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Biomarkers)
RN  - 0 (Glucuronides)
RN  - 0 (Sulfates)
SB  - IM
MH  - Biomarkers/urine
MH  - Brazil
MH  - Cross-Sectional Studies
MH  - Diet
MH  - Female
MH  - *Fruit
MH  - *Glucuronides
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Metabolomics
MH  - Sulfates
OTO - NOTNLM
OT  - 24-h urine
OT  - dietary assessment
OT  - globodiet
OT  - mass spectrometry
OT  - metabolomics
EDAT- 2022/06/01 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/05/31 21:23
PHST- 2021/12/06 00:00 [received]
PHST- 2022/03/11 00:00 [revised]
PHST- 2022/05/24 00:00 [accepted]
PHST- 2022/06/01 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/05/31 21:23 [entrez]
AID - S0022-3166(22)00717-9 [pii]
AID - 10.1093/jn/nxac115 [doi]
PST - ppublish
SO  - J Nutr. 2022 Sep 6;152(9):2023-2030. doi: 10.1093/jn/nxac115.