PMID- 35641283
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220602
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 42
IP  - 6
DP  - 2022 Jun
TI  - Preoperative S-1 Therapy for Head and Neck Carcinoma During the Waiting Period 
      Before Surgery.
PG  - 3177-3183
LID - 10.21873/anticanres.15807 [doi]
AB  - BACKGROUND/AIM: In patients with squamous cell carcinoma of the head and neck 
      (SCCHN), delayed surgery can result in poorer postoperative function and 
      prognosis due to the growth of the tumor and extended surgery. Further, delay may 
      even make the tumor unresectable. To prevent tumor growth during the waiting 
      period before surgery, S-1 has been administrated preoperatively at several 
      facilities in Japan. To date, however, the safety and efficacy of preoperative 
      S-1 remain unclear. PATIENTS AND METHODS: We conducted a retrospective cohort 
      study of 118 patients with SCCHN treated with S-1 before radical surgery at 2 
      institutions in Japan. We evaluated the safety of S-1 therapy, which was 
      evaluated by the incidence of grade 3 or greater adverse events (AEs). The rate 
      of achievement of non-growth of tumors was also calculated. RESULTS: Regarding 
      safety, 125 AEs of all grades were recorded in 71 patients (60%). Of these, grade 
      3 AEs were detected in 3 patients (3%), and no grade 4 or 5 AEs occurred. The 
      nongrowth rate of primary lesions and lymph node metastases was 89% and 85%, 
      respectively. CONCLUSION: Preoperative S-1 therapy might be useful, with 
      acceptable toxicity, on an outpatient basis in patients with SCCHN.
CI  - Copyright (c) 2022 International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Matsuki, Takashi
AU  - Matsuki T
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University 
      School of Medicine, Sagamihara, Japan; matsuki@med.kitasato-u.ac.jp.
AD  - Department of Head and Neck Oncology and Surgery, International University of 
      Health and Welfare Mita Hospital, Tokyo, Japan.
FAU - Fushimi, Chihiro
AU  - Fushimi C
AD  - Department of Head and Neck Oncology and Surgery, International University of 
      Health and Welfare Mita Hospital, Tokyo, Japan.
FAU - Miyamoto, Shunsuke
AU  - Miyamoto S
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University 
      School of Medicine, Sagamihara, Japan.
FAU - Takahashi, Hideaki
AU  - Takahashi H
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City 
      University Graduate School of Medical Sciences, Yokohama, Japan.
FAU - Masubuchi, Tatsuo
AU  - Masubuchi T
AD  - Department of Head and Neck Oncology and Surgery, International University of 
      Health and Welfare Mita Hospital, Tokyo, Japan.
FAU - Tada, Yuichiro
AU  - Tada Y
AD  - Department of Head and Neck Oncology and Surgery, International University of 
      Health and Welfare Mita Hospital, Tokyo, Japan.
FAU - Miura, Kouki
AU  - Miura K
AD  - Department of Head and Neck Oncology and Surgery, International University of 
      Health and Welfare Mita Hospital, Tokyo, Japan.
FAU - Kamata, Shin-Etsu
AU  - Kamata SE
AD  - Department of Head and Neck Oncology and Surgery, International University of 
      Health and Welfare Mita Hospital, Tokyo, Japan.
FAU - Kano, Koichi
AU  - Kano K
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University 
      School of Medicine, Sagamihara, Japan.
FAU - Tsutsumi, Shohei
AU  - Tsutsumi S
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University 
      School of Medicine, Sagamihara, Japan.
FAU - Momiyama, Kaho
AU  - Momiyama K
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University 
      School of Medicine, Sagamihara, Japan.
FAU - Yamashita, Taku
AU  - Yamashita T
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University 
      School of Medicine, Sagamihara, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - *Carcinoma, Squamous Cell/drug therapy/pathology/surgery
MH  - *Head and Neck Neoplasms/drug therapy/surgery
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Neoadjuvant Therapy
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck/drug therapy/surgery
OTO - NOTNLM
OT  - Head and neck squamous cell carcinoma
OT  - S-1
OT  - adverse event
OT  - preoperative chemotherapy
OT  - surgical case
EDAT- 2022/06/01 06:00
MHDA- 2022/06/03 06:00
CRDT- 2022/05/31 21:48
PHST- 2022/04/07 00:00 [received]
PHST- 2022/05/05 00:00 [revised]
PHST- 2022/05/09 00:00 [accepted]
PHST- 2022/05/31 21:48 [entrez]
PHST- 2022/06/01 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
AID - 42/6/3177 [pii]
AID - 10.21873/anticanres.15807 [doi]
PST - ppublish
SO  - Anticancer Res. 2022 Jun;42(6):3177-3183. doi: 10.21873/anticanres.15807.