PMID- 35641416 OWN - NLM STAT- MEDLINE DCOM- 20221004 LR - 20221004 IS - 2211-5684 (Electronic) IS - 2211-5684 (Linking) VI - 103 IP - 10 DP - 2022 Oct TI - Early enlarging cavitation after percutaneous radiofrequency ablation of lung tumors: Incidence, risk factors and outcome. PG - 464-471 LID - S2211-5684(22)00094-8 [pii] LID - 10.1016/j.diii.2022.05.004 [doi] AB - PURPOSE: The purpose of this study was to retrospectively determine the incidence of early enlarging cavitation after percutaneous radiofrequency ablation (RFA) of lung tumor and identify risk factors associated with their occurrence. PATIENTS AND METHODS: A total of 245 patients (140 men, 105 women; mean age, 62.7 +/- 11.8 [SD] years; age range: 31-87 years) with 605 lung tumors who were treated using 401 RFA sessions from April 2010 to March 2020 were included. Of which, 31 patients with 38 early enlarging cavitation and control group (151 patients with 228 tumors) were analyzed. Early enlarging cavitation was defined as cavities with an enlarged size (>3 cm) occurring on ablated lesions within seven days after RFA. Incidence of cavitation, risk and post-procedural factors of occurrence, major adverse events (AEs) that occurred in RFA sessions with cavitation, and course of cavitation were evaluated. AEs were classified using the CIRSE classification system for complications. RESULTS: Thirty-eight cavities (6.3%, 38/605 tumors) in 31 patients occurred in an average of 3.1 +/- 1.7 days (range, 1-7 days) after 32 RFA sessions. Distance from pleura >/= 20 mm, contact with vessel >/= 3 mm, multitined expandable electrode >/= 3 cm, and bronchus >/= 2 mm encompassed in the ablation zone were independent risk factors of occurrence. Fever >/= 38.5 degrees C, white blood cell count >/= 10,000/mul one day after RFA, and steroid therapy were independent post-procedural factors of occurrence. Twenty-four Grade 3 and two Grade 6 AEs occurred. Twenty-nine cavities disappeared within a mean duration of 111.9 +/- 64.9 (SD) days (range: 44-274 days) and four remained with a mean follow-up of 279.2 +/- 174 (SD) days; five patients were lost to follow-up. CONCLUSIONS: Early enlarging cavitation occurs in 6.3% of lung tumors treated with RFA and are associated with 26 major AEs in 32 sessions. Aforementioned procedural factors and post-procedural inflammation were significant risk factors of occurrence. CI - Copyright (c) 2022 Societe francaise de radiologie. Published by Elsevier Masson SAS. All rights reserved. FAU - Tomita, Koji AU - Tomita K AD - Department of Radiology, Okayama University Hospital, 2-5-1 Shikata-cho kita-ku, Okayama 700-8558, Japan. Electronic address: kotomita@okayama-u.ac.jp. FAU - Iguchi, Toshihiro AU - Iguchi T AD - Department of Radiology, Okayama University Hospital, 2-5-1 Shikata-cho kita-ku, Okayama 700-8558, Japan; Department of Radiological Technology, Faculty of Health Sciences, Okayama University, 2-5-1 Shikata-cho kita-ku, Okayama 700-8558, Japan. FAU - Matsui, Yusuke AU - Matsui Y AD - Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 700-8558, Japan. FAU - Uka, Mayu AU - Uka M AD - Department of Radiology, Okayama University Hospital, 2-5-1 Shikata-cho kita-ku, Okayama 700-8558, Japan. FAU - Umakoshi, Noriyuki AU - Umakoshi N AD - Department of Radiology, Okayama University Hospital, 2-5-1 Shikata-cho kita-ku, Okayama 700-8558, Japan. FAU - Mitsuhashi, Toshiharu AU - Mitsuhashi T AD - Center for Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho kita-ku, Okayama 700-8558, Japan. FAU - Sakurai, Jun AU - Sakurai J AD - Center for Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho kita-ku, Okayama 700-8558, Japan. FAU - Gobara, Hideo AU - Gobara H AD - Division of Medical Informatics, Okayama University Hospital, 2-5-1 Shikatacho, Kitaku, Okayama 700-8558, Japan. FAU - Kanazawa, Susumu AU - Kanazawa S AD - Department of Diagnostic and Therapeutic Radiology, Kawasaki Medical School Medical Center, 2-6-1 Nakasange Kita-ku, Okayama 700-8505, Japan. FAU - Hiraki, Takao AU - Hiraki T AD - Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kitaku, Okayama 700-8558, Japan. LA - eng PT - Journal Article DEP - 20220528 PL - France TA - Diagn Interv Imaging JT - Diagnostic and interventional imaging JID - 101568499 RN - 0 (Steroids) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - *Catheter Ablation/adverse effects MH - Female MH - Humans MH - Incidence MH - *Lung Neoplasms/pathology/surgery MH - Male MH - Middle Aged MH - *Radiofrequency Ablation MH - Retrospective Studies MH - Risk Factors MH - Steroids MH - Treatment Outcome OTO - NOTNLM OT - Adverse events OT - Lung neoplasms OT - Radiofrequency ablation COIS- Disclosure of Competing Interest The authors declare that they have no competing of interest. EDAT- 2022/06/01 06:00 MHDA- 2022/10/05 06:00 CRDT- 2022/05/31 22:07 PHST- 2022/03/21 00:00 [received] PHST- 2022/05/13 00:00 [revised] PHST- 2022/05/14 00:00 [accepted] PHST- 2022/06/01 06:00 [pubmed] PHST- 2022/10/05 06:00 [medline] PHST- 2022/05/31 22:07 [entrez] AID - S2211-5684(22)00094-8 [pii] AID - 10.1016/j.diii.2022.05.004 [doi] PST - ppublish SO - Diagn Interv Imaging. 2022 Oct;103(10):464-471. doi: 10.1016/j.diii.2022.05.004. Epub 2022 May 28.