PMID- 35641641
OWN - NLM
STAT- MEDLINE
DCOM- 20220628
LR  - 20220628
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 414
IP  - 17
DP  - 2022 Jul
TI  - Highly sensitive analysis of low-molecular-mass aldehydes in beverages using a 
      hydroxylamine reagent by high-performance liquid chromatography with fluorescence 
      detection.
PG  - 5009-5022
LID - 10.1007/s00216-022-04132-1 [doi]
AB  - In this study, a fluorescent reagent, 4-((aminooxy)methyl)-7-hydroxycoumarin 
      (AOHC), was for the first time applied to label the low-molecular-mass aldehydes 
      (LMMAs) through reductive oxyamination reaction to afford single N,O-substituted 
      oxyamine derivatives at room temperatures with derivatization efficiencies as 
      high as 96.8%. In the following high-performance liquid chromatography with 
      fluorescence detection analysis, 12 LMMAs, including furfurals, aromatic 
      aldehydes, and aliphatic aldehydes, were baseline-separated on an ODS column and 
      detected with low limits of detection (LODs) (0.2-50 nM), and good precisions 
      (intraday relative standard deviations [RSDs] were 2.40-4.68%, and interday RSDs 
      were 4.65-8.91%). This approach was then adopted to analyze six alcoholic 
      beverages and five dairy products, and nine LMMAs with concentrations in the 
      0.28-798.16 muM range were successfully detected with excellent accuracies 
      (recoveries were 92.2-106.2%). Finally, the results were statistically analyzed 
      and discussed. The proposed method has several advantages, including high 
      sensitivity, room-temperature labeling, and the avoidance of further extraction 
      and/or enrichment procedures, demonstrating its great utility for monitoring 
      LMMAs in various complex matrices.
CI  - (c) 2022. Springer-Verlag GmbH Germany, part of Springer Nature.
FAU - Liu, Ran
AU  - Liu R
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China.
FAU - Mao, Long
AU  - Mao L
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China.
FAU - Guan, Zhaobing
AU  - Guan Z
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China.
FAU - Wang, Chengsheng
AU  - Wang C
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China.
FAU - Xu, Jing
AU  - Xu J
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China.
FAU - Huang, Lujie
AU  - Huang L
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China.
FAU - Wang, Peike
AU  - Wang P
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China.
FAU - Xin, Guolin
AU  - Xin G
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China.
FAU - Hu, Rui
AU  - Hu R
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China.
FAU - Zhang, Chuyu
AU  - Zhang C
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China.
FAU - Zhao, Zihan
AU  - Zhao Z
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China.
FAU - Lin, Yawei
AU  - Lin Y
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China. 
      linyawei2012@whut.edu.cn.
FAU - Hu, Xiaosong
AU  - Hu X
AD  - Department of Chemistry, School of Chemistry, Chemical Engineering and Life 
      Sciences, Wuhan University of Technology, Wuhan, 430070, China. xhu@whut.edu.cn.
LA  - eng
GR  - 2021IA001/Fundamental Research Funds for the Central Universities/
GR  - 21472144/Fundamental Research Funds for the Central Universities/
GR  - 20192h0170/Wuhan Municipal health commission/
PT  - Journal Article
DEP - 20220531
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Aldehydes)
RN  - 0 (Hydroxylamines)
RN  - 0 (Indicators and Reagents)
RN  - 2FP81O2L9Z (Hydroxylamine)
SB  - IM
MH  - *Aldehydes/analysis
MH  - *Beverages/analysis
MH  - Chromatography, High Pressure Liquid/methods
MH  - Hydroxylamine
MH  - Hydroxylamines/analysis
MH  - Indicators and Reagents
OTO - NOTNLM
OT  - 4-((aminooxy)methyl)-7-hydroxycoumarin
OT  - Alcoholic beverages
OT  - Dairy products
OT  - High-performance liquid chromatography-fluorescence detection
OT  - Low-molecular-mass aldehydes
OT  - Reductive oxyamination
EDAT- 2022/06/01 06:00
MHDA- 2022/06/29 06:00
CRDT- 2022/05/31 23:34
PHST- 2022/02/19 00:00 [received]
PHST- 2022/05/16 00:00 [accepted]
PHST- 2022/04/22 00:00 [revised]
PHST- 2022/06/01 06:00 [pubmed]
PHST- 2022/06/29 06:00 [medline]
PHST- 2022/05/31 23:34 [entrez]
AID - 10.1007/s00216-022-04132-1 [pii]
AID - 10.1007/s00216-022-04132-1 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2022 Jul;414(17):5009-5022. doi: 10.1007/s00216-022-04132-1. 
      Epub 2022 May 31.